对miR-290和miR-302集群在iPSC重编程中的作用的关键见解。

IF 3.6 2区医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

STEM CELLS Pub Date : 2025-09-17 DOI:10.1093/stmcls/sxaf045

Shan Tao, Xianghui Zhang, Chengqiang Jin

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引用次数: 0

摘要

Ye等人发表在《干细胞》杂志上的这项研究代表了细胞重编程和多能性领域的重大进展。作者仔细研究了miR-290和miR-302 microRNA簇在成纤维细胞重编程为诱导多能干细胞（iPSCs）中的重要作用。这项工作的特点是其全面的实验设计和严格的方法，为iPSC形成的分子机制提供了新的见解。

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Critical insights into the role of miR-290 and miR-302 clusters in iPSC reprogramming.

The study by Ye et al., published in Stem Cells, represents a significant advancement in the field of cellular reprogramming and pluripotency. The authors meticulously investigate the essential roles of the miR-290 and miR-302 microRNA clusters in the reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs). This work is distinguished by its comprehensive experimental design and rigorous methodology, providing novel insights into the molecular mechanisms underlying iPSC formation.

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来源期刊

STEM CELLS 医学-生物工程与应用微生物

CiteScore

10.30

自引率

1.90%

发文量

104

审稿时长

3 months

期刊介绍： STEM CELLS, a peer reviewed journal published monthly, provides a forum for prompt publication of original investigative papers and concise reviews. STEM CELLS is read and written by clinical and basic scientists whose expertise encompasses the rapidly expanding fields of stem and progenitor cell biology. STEM CELLS covers: Cancer Stem Cells, Embryonic Stem Cells/Induced Pluripotent Stem (iPS) Cells, Regenerative Medicine, Stem Cell Technology: Epigenetics, Genomics, Proteomics, and Metabonomics, Tissue-Specific Stem Cells, Translational and Clinical Research.