基于植物启发的金纳米粒子(AuNPs)的纳米医学和分子成像用于乳腺癌药物输送

IF 3.7 2区 化学 Q2 CHEMISTRY, APPLIED
Ravikant Shekhar, H. S. Prakash, Chandan Shivamallu, Shiva Prasad Panjala, Mostafa Abdelrahman, Sudisha Jogaiah, Nagaraj Geetha
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引用次数: 0

摘要

乳腺癌是全世界妇女中最常见的恶性肿瘤,其治疗常常受到遗传和非遗传耐药机制的挑战。本研究提出了一种新颖、环保的方法,利用Piper betle var. Mysuru的乙酸乙酯提取物合成金纳米颗粒(AuNPs), Piper betle var. Mysuru是一种重要的农业植物,以其生物活性植物化学物质而闻名。这种绿色合成方法不仅最大限度地减少了对环境的影响,而且提高了所产生的纳米颗粒的治疗潜力。对AuNPs进行了表征,发现其具有面心立方晶格的球形纳米晶体性质,直径范围为14 ~ 34 nm(平均25 nm)。AuNPs对MCF-7乳腺癌细胞株显示出显著的细胞毒性,IC50值为9.06±0.51 μg/mL,优于植物提取物和常规疗法。溶血试验进一步证实了其安全性,溶血最小(8.67%),支持其安全体循环的潜力。该研究的新颖之处在于确定了脱苷,这是一种贝属植物中的生物活性化合物,是EGFR信号通路的有效抑制剂。分子对接和动态模拟揭示了脱糖苷和靶蛋白之间的强结合相互作用,破坏了癌细胞增殖的关键途径。这项工作强调了P. betle介导的AuNPs作为一种可持续的、可扩展的、高效的乳腺癌治疗方案的潜力。它们的可负担性、环保性和增强的治疗效果强调了它们在临床应用和大规模生产方面的前景,为减少副作用的高级癌症治疗铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Plant-Inspired Gold Nanoparticles (AuNPs)-Based Nanomedicine and Molecular Imaging for Breast Cancer Drug Delivery

Plant-Inspired Gold Nanoparticles (AuNPs)-Based Nanomedicine and Molecular Imaging for Breast Cancer Drug Delivery

Breast cancer is the most commonly diagnosed malignancy among women worldwide, with treatment often challenged by genetic and non-genetic resistance mechanisms. This study presents a novel, eco-friendly approach for synthesizing gold nanoparticles (AuNPs) using the ethyl acetate extract of Piper betle var. Mysuru, an agriculturally significant plant known for its bioactive phytochemicals. This green synthesis method not only minimizes environmental impact but also enhances the therapeutic potential of the resulting nanoparticles. Characterization of the AuNPs revealed their spherical, nanocrystalline nature with a face-centered cubic lattice and diameters ranging from 14 to 34 nm (25 nm average). The AuNPs demonstrated remarkable cytotoxicity against MCF-7 breast cancer cell lines, achieving an IC50 value of 9.06 ± 0.51 μg/mL, outperforming plant extracts and conventional therapies. Hemolytic assays further confirmed their safety, with minimal hemolysis (8.67%), supporting their potential for safe systemic circulation. The study's novelty is identifying decoside, a bioactive compound in P. betle, as a potent inhibitor of the EGFR signaling pathway. Molecular docking and dynamic simulations revealed strong binding interactions between decoside and target proteins, disrupting pathways critical to cancer cell proliferation. This work highlights the potential of P. betle-mediated AuNPs as a sustainable, scalable, and highly effective solution for breast cancer therapy. Their affordability, eco-friendliness, and enhanced therapeutic efficacy underscore their promise for clinical applications and large-scale production, paving the way for advanced cancer therapeutics with reduced side effects.

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来源期刊
Applied Organometallic Chemistry
Applied Organometallic Chemistry 化学-无机化学与核化学
CiteScore
7.80
自引率
10.30%
发文量
408
审稿时长
2.2 months
期刊介绍: All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.
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