Shah Fahad Khan, Muhammad Akhlaq, Jiang Ni, Anam Razzaq, Haroon Iqbal, Zaheer Ullah Khan, Asmat Ullah, Serag Eldin I. Elbehairi, Ali A. Shati, Mohammad Y. Alfaifi, Naveed Ullah Khan, Abid Hussain, Qiufang Gao
{"title":"基于自纳米乳化系统的法莫替丁递送改善口服生物利用度:体外和体内评价","authors":"Shah Fahad Khan, Muhammad Akhlaq, Jiang Ni, Anam Razzaq, Haroon Iqbal, Zaheer Ullah Khan, Asmat Ullah, Serag Eldin I. Elbehairi, Ali A. Shati, Mohammad Y. Alfaifi, Naveed Ullah Khan, Abid Hussain, Qiufang Gao","doi":"10.1007/s10876-025-02850-x","DOIUrl":null,"url":null,"abstract":"<div><p>Pharmaceutical experts have focused on the Self-Nano Emulsifying Drug Delivery System (SNEDDS) in recent years as a promising strategy to enhance the bioavailability of poorly absorbed drugs. Using famotidine, a drug with low bioavailability—as a model, this study aimed to evaluate the potential of SNEDDS for improving drug absorption. Fish oil-based SNEDDS formulations incorporating Tween 80 (surfactant) and propylene glycol (co-surfactant) were developed using pseudo-ternary phase diagrams and optimized via Box-Behnken design. The formulations underwent thermodynamic stability testing, physicochemical characterization, as well as in vitro and in vivo evaluations. SNEDDS revealed excellent thermodynamic stability and desired particle’s size characteristics. The formulations showed a sustained release pattern after initial burst release. The FTIR-spectrum confirmed the incorporation and stability of FM in SNEDDS. The cell uptake study in Caco2 cells showed significantly higher uptake for SNEDDS as compared to control, providing proof of concept to improve bioavailability. The ex vivo data displayed the thoroughgoing infiltration of SNEDDS in the mucus layers. The in vivo results declared desirable hemocompatibility of SNEDDS and decidedly enhanced passage of hydrophobic drug into the systemic circulation, improving its bioavailability. The formulations showed excellent elevation of in vivo oral bioavailability, proving that the designed oral dosage form can be a potent clinical slant regarding oral delivery of low soluble drugs for clinicians.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 4","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Self-Nano Emulsifying System-Based Delivery of Famotidine for Improved Oral Bioavailability: In Vitro and In Vivo Evaluations\",\"authors\":\"Shah Fahad Khan, Muhammad Akhlaq, Jiang Ni, Anam Razzaq, Haroon Iqbal, Zaheer Ullah Khan, Asmat Ullah, Serag Eldin I. Elbehairi, Ali A. Shati, Mohammad Y. Alfaifi, Naveed Ullah Khan, Abid Hussain, Qiufang Gao\",\"doi\":\"10.1007/s10876-025-02850-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Pharmaceutical experts have focused on the Self-Nano Emulsifying Drug Delivery System (SNEDDS) in recent years as a promising strategy to enhance the bioavailability of poorly absorbed drugs. Using famotidine, a drug with low bioavailability—as a model, this study aimed to evaluate the potential of SNEDDS for improving drug absorption. Fish oil-based SNEDDS formulations incorporating Tween 80 (surfactant) and propylene glycol (co-surfactant) were developed using pseudo-ternary phase diagrams and optimized via Box-Behnken design. The formulations underwent thermodynamic stability testing, physicochemical characterization, as well as in vitro and in vivo evaluations. SNEDDS revealed excellent thermodynamic stability and desired particle’s size characteristics. The formulations showed a sustained release pattern after initial burst release. The FTIR-spectrum confirmed the incorporation and stability of FM in SNEDDS. The cell uptake study in Caco2 cells showed significantly higher uptake for SNEDDS as compared to control, providing proof of concept to improve bioavailability. The ex vivo data displayed the thoroughgoing infiltration of SNEDDS in the mucus layers. The in vivo results declared desirable hemocompatibility of SNEDDS and decidedly enhanced passage of hydrophobic drug into the systemic circulation, improving its bioavailability. The formulations showed excellent elevation of in vivo oral bioavailability, proving that the designed oral dosage form can be a potent clinical slant regarding oral delivery of low soluble drugs for clinicians.</p></div>\",\"PeriodicalId\":618,\"journal\":{\"name\":\"Journal of Cluster Science\",\"volume\":\"36 4\",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-06-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cluster Science\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10876-025-02850-x\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cluster Science","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10876-025-02850-x","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Self-Nano Emulsifying System-Based Delivery of Famotidine for Improved Oral Bioavailability: In Vitro and In Vivo Evaluations
Pharmaceutical experts have focused on the Self-Nano Emulsifying Drug Delivery System (SNEDDS) in recent years as a promising strategy to enhance the bioavailability of poorly absorbed drugs. Using famotidine, a drug with low bioavailability—as a model, this study aimed to evaluate the potential of SNEDDS for improving drug absorption. Fish oil-based SNEDDS formulations incorporating Tween 80 (surfactant) and propylene glycol (co-surfactant) were developed using pseudo-ternary phase diagrams and optimized via Box-Behnken design. The formulations underwent thermodynamic stability testing, physicochemical characterization, as well as in vitro and in vivo evaluations. SNEDDS revealed excellent thermodynamic stability and desired particle’s size characteristics. The formulations showed a sustained release pattern after initial burst release. The FTIR-spectrum confirmed the incorporation and stability of FM in SNEDDS. The cell uptake study in Caco2 cells showed significantly higher uptake for SNEDDS as compared to control, providing proof of concept to improve bioavailability. The ex vivo data displayed the thoroughgoing infiltration of SNEDDS in the mucus layers. The in vivo results declared desirable hemocompatibility of SNEDDS and decidedly enhanced passage of hydrophobic drug into the systemic circulation, improving its bioavailability. The formulations showed excellent elevation of in vivo oral bioavailability, proving that the designed oral dosage form can be a potent clinical slant regarding oral delivery of low soluble drugs for clinicians.
期刊介绍:
The journal publishes the following types of papers: (a) original and important research;
(b) authoritative comprehensive reviews or short overviews of topics of current
interest; (c) brief but urgent communications on new significant research; and (d)
commentaries intended to foster the exchange of innovative or provocative ideas, and
to encourage dialogue, amongst researchers working in different cluster
disciplines.