Ag-CeO2纳米复合材料的抗菌和抗癌活性

IF 3.6 4区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR
P. C. Nagajyothi, Kuruvalli Gouthami, Subhasish Maity, K. Pavani, Clement Okraku Tettey, Vaddi Damodara Reddy, Jaesool Shim
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引用次数: 0

摘要

在这项研究中,小凹骨种子介导的AgNPs沉积在mof衍生的CeO 2表面。采用XRD、EDX、FTIR、SEM和HR-TEM等技术表征了Ag-CeO₂NC的结构、元素、化学、功能和形貌。XRD结果表明复合材料中存在AgNPs和CeO 2 NPs。红外光谱研究揭示了复合材料中七种不同的官能团。SEM和TEM结果表明,球形AgNPs分布良好。能谱分析证实合成的复合材料中存在Ce、Ag和O。Ag-CeO 2纳米复合材料对金黄色葡萄球菌、铜绿假单胞菌、枯草芽孢杆菌和大肠杆菌具有显著的抗菌活性。最低抑菌浓度(MIC)为60 ~ 80µg/mL, 80µg/mL时活性最佳,对金黄色葡萄球菌的清除率为10.23±0.46 mm,对铜绿假单胞菌的清除率为6.09±0.13 mm,对枯草芽孢杆菌的清除率为11.29±0.39 mm,对大肠杆菌的清除率为11.25±0.45 mm。这些结果表明Ag-CeO 2纳米复合材料具有作为一种有效抗菌剂的潜力。此外,我们还评估了Ag-CeO2 NC对MCF-7人乳腺癌细胞的抗癌潜力。MTT实验表明,细胞活力随着Ag-CeO 2 NC浓度的增加而下降,浓度范围为2.5 ~ 50µg/mL。总的来说,合成的Ag-CeO2 NC显示出作为抗细菌感染和癌细胞增殖的有效药物的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antibacterial and Anticancer Activity of Ag-CeO2 Nanocomposite

In this study, Foeniculum vulgare seed-mediated AgNPs were deposited onto the surface of MOF-derived CeO₂. The structural, elemental, chemical, functional, and morphological properties of the Ag-CeO₂ NC were characterized using XRD, EDX, FTIR, SEM, and HR-TEM techniques. XRD results indicate the presence of AgNPs and CeO₂ NPs in the composite. FTIR studies revealed seven different functional groups in the composite. SEM and TEM results indicate the spherical-shaped AgNPs are well distributed on the CeO₂ flakes. EDS analysis confirms the presence of Ce, Ag, and O in the synthesized composite. Ag-CeO₂ nanocomposite exhibited significant antibacterial activity against S. aureus, P. aeruginosa, B. substilis, and E. coli. The minimum inhibitory concentration (MIC) values were achieved at concentrations of 60–80 µg/mL, with optimal activity observed at 80 µg/mL, resulting in zone of clearance values of 10.23 ± 0.46 mm against Staphylococcus aureus, 6.09 ± 0.13 mm against Pseudomonas aeruginosa, 11.29 ± 0.39 mm against Bacillus subtilis and 11.25 ± 0.45 mm against E. coli. These results suggest that the Ag-CeO₂ nanocomposite has potential as an effective antibacterial agent. Furthermore, the anticancer potential of the Ag-CeO2 NC was assessed on MCF-7 human breast cancer cells. The MTT assay showed that cell viability decreased with increasing Ag-CeO₂ NC concentrations, ranging from 2.5 to 50 µg/mL. Overall, the synthesized Ag-CeO2 NC demonstrates promise as an effective agent against bacterial infections and cancer cell proliferation.

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来源期刊
Journal of Cluster Science
Journal of Cluster Science 化学-无机化学与核化学
CiteScore
6.70
自引率
0.00%
发文量
166
审稿时长
3 months
期刊介绍: The journal publishes the following types of papers: (a) original and important research; (b) authoritative comprehensive reviews or short overviews of topics of current interest; (c) brief but urgent communications on new significant research; and (d) commentaries intended to foster the exchange of innovative or provocative ideas, and to encourage dialogue, amongst researchers working in different cluster disciplines.
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