Rizka Utami, Muhammad Hisyam Habani, Sunaryono Sunaryono, Munasir Munasir, Nor Suriani Sani, Erlina Yustanti, Dahlang Tahir, Ahmad Taufiq
{"title":"天然磁铁矿/羟基磷灰石/壳聚糖纳米复合材料作为有效的药物递送系统","authors":"Rizka Utami, Muhammad Hisyam Habani, Sunaryono Sunaryono, Munasir Munasir, Nor Suriani Sani, Erlina Yustanti, Dahlang Tahir, Ahmad Taufiq","doi":"10.1007/s10876-025-02861-8","DOIUrl":null,"url":null,"abstract":"<div><p>In recent years, chemotherapy has been widely reported as a treatment for cancer. However, most patients experience side effects of chemotherapy due to direct exposure of drugs such as doxorubicin to body tissues. This work seeks an effective magnetic-based drug delivery system, where the system can maximally load the drug and is able to release the drug in a controlled manner. In this study, the magnetite/hydroxyapatite/chitosan nanocomposite was synthesized through the coprecipitation route, utilizing the natural resources of iron sand and serai snail shells. The crystals formed are sized 9.22–9.63 nm for magnetite and 7.94–8.70 nm for hydroxyapatite. Infrared analysis has shown the presence of M–O, OH<sup>–</sup>, PO<sub>4</sub><sup>3–</sup>, and NH<sub>2</sub>. Additionally, morphology of the magnetite/hydroxyapatite/chitosan nanocomposite consists of spherical particles with a size of 28.1–32.3 nm. Composition of chitosan reducing the band gap energy. The nanocomposites showed superparamagnetic with a saturation magnetization of 8.9–11.1 emu.g<sup>–1</sup>. Antibacterial activity investigations revealed that the nanocomposites formed an inhibition zone diameter of 2–8 mm. Doxorubicin was successfully loaded with a drug loading efficiency ranging from 76 to 82%. Based on the release kinetics, doxorubicin demonstrated a rapid release with maximum value within the first 135 min. Therefore, this study has successfully developed a drug delivery system responsive to magnetic fields, capable of loading high-capacity drugs and releasing them at target sites, thereby positioning this material as a promising candidate in cancer treatment systems.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 4","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Natural-Based Magnetite/Hydroxyapatite/Chitosan Nanocomposite as Effective Drug Delivery Systems\",\"authors\":\"Rizka Utami, Muhammad Hisyam Habani, Sunaryono Sunaryono, Munasir Munasir, Nor Suriani Sani, Erlina Yustanti, Dahlang Tahir, Ahmad Taufiq\",\"doi\":\"10.1007/s10876-025-02861-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In recent years, chemotherapy has been widely reported as a treatment for cancer. However, most patients experience side effects of chemotherapy due to direct exposure of drugs such as doxorubicin to body tissues. This work seeks an effective magnetic-based drug delivery system, where the system can maximally load the drug and is able to release the drug in a controlled manner. In this study, the magnetite/hydroxyapatite/chitosan nanocomposite was synthesized through the coprecipitation route, utilizing the natural resources of iron sand and serai snail shells. The crystals formed are sized 9.22–9.63 nm for magnetite and 7.94–8.70 nm for hydroxyapatite. Infrared analysis has shown the presence of M–O, OH<sup>–</sup>, PO<sub>4</sub><sup>3–</sup>, and NH<sub>2</sub>. Additionally, morphology of the magnetite/hydroxyapatite/chitosan nanocomposite consists of spherical particles with a size of 28.1–32.3 nm. Composition of chitosan reducing the band gap energy. The nanocomposites showed superparamagnetic with a saturation magnetization of 8.9–11.1 emu.g<sup>–1</sup>. Antibacterial activity investigations revealed that the nanocomposites formed an inhibition zone diameter of 2–8 mm. Doxorubicin was successfully loaded with a drug loading efficiency ranging from 76 to 82%. Based on the release kinetics, doxorubicin demonstrated a rapid release with maximum value within the first 135 min. Therefore, this study has successfully developed a drug delivery system responsive to magnetic fields, capable of loading high-capacity drugs and releasing them at target sites, thereby positioning this material as a promising candidate in cancer treatment systems.</p></div>\",\"PeriodicalId\":618,\"journal\":{\"name\":\"Journal of Cluster Science\",\"volume\":\"36 4\",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-06-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cluster Science\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10876-025-02861-8\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cluster Science","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10876-025-02861-8","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Natural-Based Magnetite/Hydroxyapatite/Chitosan Nanocomposite as Effective Drug Delivery Systems
In recent years, chemotherapy has been widely reported as a treatment for cancer. However, most patients experience side effects of chemotherapy due to direct exposure of drugs such as doxorubicin to body tissues. This work seeks an effective magnetic-based drug delivery system, where the system can maximally load the drug and is able to release the drug in a controlled manner. In this study, the magnetite/hydroxyapatite/chitosan nanocomposite was synthesized through the coprecipitation route, utilizing the natural resources of iron sand and serai snail shells. The crystals formed are sized 9.22–9.63 nm for magnetite and 7.94–8.70 nm for hydroxyapatite. Infrared analysis has shown the presence of M–O, OH–, PO43–, and NH2. Additionally, morphology of the magnetite/hydroxyapatite/chitosan nanocomposite consists of spherical particles with a size of 28.1–32.3 nm. Composition of chitosan reducing the band gap energy. The nanocomposites showed superparamagnetic with a saturation magnetization of 8.9–11.1 emu.g–1. Antibacterial activity investigations revealed that the nanocomposites formed an inhibition zone diameter of 2–8 mm. Doxorubicin was successfully loaded with a drug loading efficiency ranging from 76 to 82%. Based on the release kinetics, doxorubicin demonstrated a rapid release with maximum value within the first 135 min. Therefore, this study has successfully developed a drug delivery system responsive to magnetic fields, capable of loading high-capacity drugs and releasing them at target sites, thereby positioning this material as a promising candidate in cancer treatment systems.
期刊介绍:
The journal publishes the following types of papers: (a) original and important research;
(b) authoritative comprehensive reviews or short overviews of topics of current
interest; (c) brief but urgent communications on new significant research; and (d)
commentaries intended to foster the exchange of innovative or provocative ideas, and
to encourage dialogue, amongst researchers working in different cluster
disciplines.