天然磁铁矿/羟基磷灰石/壳聚糖纳米复合材料作为有效的药物递送系统

IF 3.6 4区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR
Rizka Utami, Muhammad Hisyam Habani, Sunaryono Sunaryono, Munasir Munasir, Nor Suriani Sani, Erlina Yustanti, Dahlang Tahir, Ahmad Taufiq
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引用次数: 0

摘要

近年来,化疗作为一种治疗癌症的方法被广泛报道。然而,大多数患者经历化疗的副作用是由于药物如阿霉素直接暴露于身体组织。这项工作寻求一种有效的磁性药物递送系统,该系统可以最大限度地装载药物,并能够以受控的方式释放药物。本研究利用天然资源铁砂和螺壳,采用共沉淀法合成了磁铁矿/羟基磷灰石/壳聚糖纳米复合材料。形成的磁铁矿晶体尺寸为9.22 ~ 9.63 nm,羟基磷灰石晶体尺寸为7.94 ~ 8.70 nm。红外分析表明,其中存在M-O、OH -、PO43 -和NH2。此外,磁铁矿/羟基磷灰石/壳聚糖纳米复合材料的形貌由28.1-32.3 nm的球形颗粒组成。壳聚糖的组成降低了带隙能。纳米复合材料具有超顺磁性,饱和磁化强度为8.9 ~ 11.1 μ g - 1。抗菌活性研究表明,纳米复合材料形成了直径为2 ~ 8 mm的抑制带。阿霉素成功装药,载药率为76% ~ 82%。释放动力学结果表明,阿霉素的释放速度较快,在135 min内达到最大值。因此,本研究成功开发了一种响应磁场的药物递送系统,能够装载大容量药物并将其释放到靶点,从而将这种材料定位为癌症治疗系统中有希望的候选者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Natural-Based Magnetite/Hydroxyapatite/Chitosan Nanocomposite as Effective Drug Delivery Systems

Natural-Based Magnetite/Hydroxyapatite/Chitosan Nanocomposite as Effective Drug Delivery Systems

In recent years, chemotherapy has been widely reported as a treatment for cancer. However, most patients experience side effects of chemotherapy due to direct exposure of drugs such as doxorubicin to body tissues. This work seeks an effective magnetic-based drug delivery system, where the system can maximally load the drug and is able to release the drug in a controlled manner. In this study, the magnetite/hydroxyapatite/chitosan nanocomposite was synthesized through the coprecipitation route, utilizing the natural resources of iron sand and serai snail shells. The crystals formed are sized 9.22–9.63 nm for magnetite and 7.94–8.70 nm for hydroxyapatite. Infrared analysis has shown the presence of M–O, OH, PO43–, and NH2. Additionally, morphology of the magnetite/hydroxyapatite/chitosan nanocomposite consists of spherical particles with a size of 28.1–32.3 nm. Composition of chitosan reducing the band gap energy. The nanocomposites showed superparamagnetic with a saturation magnetization of 8.9–11.1 emu.g–1. Antibacterial activity investigations revealed that the nanocomposites formed an inhibition zone diameter of 2–8 mm. Doxorubicin was successfully loaded with a drug loading efficiency ranging from 76 to 82%. Based on the release kinetics, doxorubicin demonstrated a rapid release with maximum value within the first 135 min. Therefore, this study has successfully developed a drug delivery system responsive to magnetic fields, capable of loading high-capacity drugs and releasing them at target sites, thereby positioning this material as a promising candidate in cancer treatment systems.

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来源期刊
Journal of Cluster Science
Journal of Cluster Science 化学-无机化学与核化学
CiteScore
6.70
自引率
0.00%
发文量
166
审稿时长
3 months
期刊介绍: The journal publishes the following types of papers: (a) original and important research; (b) authoritative comprehensive reviews or short overviews of topics of current interest; (c) brief but urgent communications on new significant research; and (d) commentaries intended to foster the exchange of innovative or provocative ideas, and to encourage dialogue, amongst researchers working in different cluster disciplines.
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