褐地衣中α-氨基酸和α-Collatolic酸的分离、鉴定及细胞毒性研究

IF 0.4 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Pub Date : 2025-06-15 DOI:10.1134/S199075082460119X

I. A. Prokopiev, O. S. Shemchuk, U. A. Kremenetskaya, O. V. Mikolaichuk, O. E. Molchanov, D. N. Maistrenko, K. N. Semenov, V. V. Sharoyko

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引用次数: 0

摘要

本文介绍了地衣中α-氨基酸和α-collatolic酸的分离纯化及细胞毒性研究的结果。描述了提取和纯化这些酸的方法，以获得高产量和纯度。细胞毒性实验表明，这两种酸对HeLa、A549细胞株均有显著的活性。所获得的数据表明，电位和collatolic酸作为新的抗肿瘤药物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Isolation, Identification, and Cytotoxicity of α-Alectoronic and α-Collatolic Acids Isolated from the Lichen Cetrelia braunsiana

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Isolation, Identification, and Cytotoxicity of α-Alectoronic and α-Collatolic Acids Isolated from the Lichen Cetrelia braunsiana

The results of the study on isolation, purification, and study of the cytotoxicity of α-alectoronic and α-collatolic acids isolated from lichens are presented in the article. The methods of extraction and purification allowing to obtain these acids with a high yield and degree of purity are described. The conducted experiments on studying cytotoxicity revealed that both acids have significant activity in relation to the cell lines HeLa, A549. Data obtained demonstrate a potential of alectoronic and collatolic acids as new antitumor agents.

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来源期刊

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.