Alexandra Bogdanova, Elizaveta Pavlova, Anna Polyanskaya, Kristina Monakhova, Marina Volkova, Elena Biryukova, Gleb Filkov, Alexander Trofimenko, Mikhail Durymanov, Elena Kovaleva, Sergey Rybalkin, Alexey Piryazev, Dimitri Ivanov, Dmitry Klinov, Dmitry Bagrov
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Comparison of the Electrospun Mats Made of Polylactide and Polydioxanone
Electrospun mats made of biodegradable polyesters are commonly used in tissue engineering. The current work compares the properties of electrospun mats made of polylactide (PLA) and polydioxanone (PDX). In these mats, the mean fiber diameters and pore sizes were similar, so the differences in their properties arose from polymer characteristics rather than the fiber size or morphology. In vitro experiments with 3T3 mouse fibroblasts demonstrated that both mats were cytocompatible and did not hinder cell proliferation. The PLA and PDX mats differed in wetting behavior, crystallinity (PLA mats were amorphous, and PDX had 18% crystallinity), degradation time, and mechanical properties. Degradation kinetics were measured both in vitro (in a buffer solution and Fenton’s reagent) and in vivo (subcutaneous implantation in mice). In both cases, the PDX mat degraded far faster (almost complete degradation in vivo on day 30) than the PLA mat (~ 30% thickness reduction on day 60). The obtained results can be valuable for the development of biodegradable electrospun scaffolds.
期刊介绍：
The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.
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