{"title":"基于HEMA-TA-PEG的新型高分子材料制备再生医学用生物基水凝胶","authors":"Hossein Rayat Pisheh, Alireza Sabzevari, Mojtaba Ansari, Kourosh Kabiri, Hossein Eslami, Mohammad Kohestanian","doi":"10.1007/s10924-025-03584-7","DOIUrl":null,"url":null,"abstract":"<div><p>In this study, bio-based hydrogels were designed and synthesized using the HEMA-TA-PEG macromer. The chemical structure of the macromer was confirmed through FTIR and <sup>1</sup>H-NMR analyses. Hydrogels with varying crosslinker (GPTMS) content were fabricated to investigate the impact of GPTMS on swelling, gel content, and mechanical properties. As the GPTMS content increased, the swelling behavior of the hydrogels decreased, whereas the gel content increased. Mechanical testing revealed a significant increase in tensile strength, with stress rising from 517 kPa to 786 kPa and the tensile modulus reaching 1.03 MPa as the GPTMS content increased from 0.25 g to 1 g. The prepared hydrogels exhibited excellent cytocompatibility, with significantly higher cell viability than the control over time (24, 48, and 72 h). Furthermore, cell adhesion in the hydrogels reached 93% at 48 h, a significant increase compared to the 85% observed in the control. These findings highlight the potential of bio-based hydrogels for applications in regenerative medicine.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 7","pages":"3076 - 3091"},"PeriodicalIF":5.0000,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis of New macromer Based on HEMA-TA-PEG for Preparation of Bio-Based Hydrogels for Regenerative Medicine Applications\",\"authors\":\"Hossein Rayat Pisheh, Alireza Sabzevari, Mojtaba Ansari, Kourosh Kabiri, Hossein Eslami, Mohammad Kohestanian\",\"doi\":\"10.1007/s10924-025-03584-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this study, bio-based hydrogels were designed and synthesized using the HEMA-TA-PEG macromer. The chemical structure of the macromer was confirmed through FTIR and <sup>1</sup>H-NMR analyses. Hydrogels with varying crosslinker (GPTMS) content were fabricated to investigate the impact of GPTMS on swelling, gel content, and mechanical properties. As the GPTMS content increased, the swelling behavior of the hydrogels decreased, whereas the gel content increased. Mechanical testing revealed a significant increase in tensile strength, with stress rising from 517 kPa to 786 kPa and the tensile modulus reaching 1.03 MPa as the GPTMS content increased from 0.25 g to 1 g. The prepared hydrogels exhibited excellent cytocompatibility, with significantly higher cell viability than the control over time (24, 48, and 72 h). Furthermore, cell adhesion in the hydrogels reached 93% at 48 h, a significant increase compared to the 85% observed in the control. These findings highlight the potential of bio-based hydrogels for applications in regenerative medicine.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":659,\"journal\":{\"name\":\"Journal of Polymers and the Environment\",\"volume\":\"33 7\",\"pages\":\"3076 - 3091\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2025-05-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Polymers and the Environment\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10924-025-03584-7\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, ENVIRONMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Polymers and the Environment","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s10924-025-03584-7","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, ENVIRONMENTAL","Score":null,"Total":0}
Synthesis of New macromer Based on HEMA-TA-PEG for Preparation of Bio-Based Hydrogels for Regenerative Medicine Applications
In this study, bio-based hydrogels were designed and synthesized using the HEMA-TA-PEG macromer. The chemical structure of the macromer was confirmed through FTIR and 1H-NMR analyses. Hydrogels with varying crosslinker (GPTMS) content were fabricated to investigate the impact of GPTMS on swelling, gel content, and mechanical properties. As the GPTMS content increased, the swelling behavior of the hydrogels decreased, whereas the gel content increased. Mechanical testing revealed a significant increase in tensile strength, with stress rising from 517 kPa to 786 kPa and the tensile modulus reaching 1.03 MPa as the GPTMS content increased from 0.25 g to 1 g. The prepared hydrogels exhibited excellent cytocompatibility, with significantly higher cell viability than the control over time (24, 48, and 72 h). Furthermore, cell adhesion in the hydrogels reached 93% at 48 h, a significant increase compared to the 85% observed in the control. These findings highlight the potential of bio-based hydrogels for applications in regenerative medicine.
期刊介绍：
The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.
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