{"title":"基于电泳力的低压微血细胞分离仪的仿真与优化","authors":"Elnaz Poorreza, Noushin Dadashzadeh Gargari","doi":"10.1134/S1061934824605280","DOIUrl":null,"url":null,"abstract":"<p>The objective of this investigation is to develop optimization approaches for the separation of platelets from red blood cells (<b>RBC</b>s). A novel microfluidic device with triangular electrodes operating at a low voltage of 1.5 V and a frequency of 100 kHz is proposed for the separation of platelets and RBCs using dielectrophoresis (<b>DEP</b>) force. Using of a low voltage ensures the preservation of the viability of biological cells, which is a crucial factor for medical applications. Through a comparative investigation utilizing the finite element method, the impact of varying electrode dimensions on the effective separation of particles is demonstrated. Profiles of electric field, pressure, and DEP force acting on two particles are presented through simulation.</p>","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 5","pages":"801 - 812"},"PeriodicalIF":1.1000,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Simulation and Optimization of a Low-Voltage Microseparator Based on Dielectrophoresis Forces for Blood Cell Separation\",\"authors\":\"Elnaz Poorreza, Noushin Dadashzadeh Gargari\",\"doi\":\"10.1134/S1061934824605280\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The objective of this investigation is to develop optimization approaches for the separation of platelets from red blood cells (<b>RBC</b>s). A novel microfluidic device with triangular electrodes operating at a low voltage of 1.5 V and a frequency of 100 kHz is proposed for the separation of platelets and RBCs using dielectrophoresis (<b>DEP</b>) force. Using of a low voltage ensures the preservation of the viability of biological cells, which is a crucial factor for medical applications. Through a comparative investigation utilizing the finite element method, the impact of varying electrode dimensions on the effective separation of particles is demonstrated. Profiles of electric field, pressure, and DEP force acting on two particles are presented through simulation.</p>\",\"PeriodicalId\":606,\"journal\":{\"name\":\"Journal of Analytical Chemistry\",\"volume\":\"80 5\",\"pages\":\"801 - 812\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-06-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Analytical Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1061934824605280\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Analytical Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1061934824605280","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Simulation and Optimization of a Low-Voltage Microseparator Based on Dielectrophoresis Forces for Blood Cell Separation
The objective of this investigation is to develop optimization approaches for the separation of platelets from red blood cells (RBCs). A novel microfluidic device with triangular electrodes operating at a low voltage of 1.5 V and a frequency of 100 kHz is proposed for the separation of platelets and RBCs using dielectrophoresis (DEP) force. Using of a low voltage ensures the preservation of the viability of biological cells, which is a crucial factor for medical applications. Through a comparative investigation utilizing the finite element method, the impact of varying electrode dimensions on the effective separation of particles is demonstrated. Profiles of electric field, pressure, and DEP force acting on two particles are presented through simulation.
期刊介绍：
The Journal of Analytical Chemistry is an international peer reviewed journal that covers theoretical and applied aspects of analytical chemistry; it informs the reader about new achievements in analytical methods, instruments and reagents. Ample space is devoted to problems arising in the analysis of vital media such as water and air. Consideration is given to the detection and determination of metal ions, anions, and various organic substances. The journal welcomes manuscripts from all countries in the English or Russian language.
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