抗生素生物降解研究进展:减轻环境污染和耐药性的新策略和挑战

IF 8.1 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Ibnu Maulana Hidayatullah, Soen Steven, Adi Kusmayadi, Iftita Rahmatika, Muhammad Reski, Ramaraj Boopathy, Muhamad Akmal Alfatan, Putri Wilhelmina Gusanti Purba
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引用次数: 0

摘要

各种疾病的爆发增加了抗生素的消耗。不幸的是,这种情况会进一步增加抗生素的积累,从而污染环境甚至人类健康。生物降解是减少甚至消除抗生素积累的一种方法。本文综述了抗生素在环境中的来源、抗生素生物降解的机制、影响生物降解过程的因素、生态风险、监管意义、目前已实施的策略以及减少抗生素耐药性和环境污染的创新方法。最近的发现最近的研究强调了水生和土壤环境中的抗生素耐药性。这增加了耐抗生素细菌种群的威胁。生物降解技术,如生物废水处理、湿地、微生物降解和藻类降解已经能够显示出令人满意的性能。特别是,细菌、真菌和微藻的微生物联合体和基因改造也可以提供协同代谢途径,提高抗生素降解效率。此外,生物纳米颗粒和酶辅助降解方法,如漆酶,可以成为抗生素生物降解的先进创新方法。随着环境污染和抗生素耐药性风险的增加,抗生素的生物降解已成为一个关键的研究热点。这一课题有望将抗生素分解成对环境更耐受的化合物。虽然抗生素的生物降解研究已经取得了一定的进展,但还需要进一步的研究来克服诸如化合物的复杂性、抗生素的稳定性、抗生素和基因耐药性现象以及非最佳环境因素等挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances in Antibiotic Biodegradation: Emerging Strategies and Challenges in Mitigating Environmental Contamination and Resistance

Purpose of Review

The various disease outbreaks have increased the consumption of antibiotics. Unfortunately, this condition can further increase the accumulation of antibiotics that can pollute the environment and even human health. Biodegradation is one method to reduce or even eliminate the accumulation of antibiotics. This review aims to discuss the sources of antibiotics in the environment, mechanisms of antibiotic biodegradation, factors affecting the biodegradation process, ecological risks, regulatory implications, current strategies that have been implemented, and innovative approaches to reduce antibiotic resistance and environmental contamination.

Recent Findings

Recent studies have highlighted antibiotic resistance in aquatic and soil environments. This increases the threat of antibiotic-resistant bacterial populations. Biodegradation techniques such as biological wastewater treatment, wetlands, microbial degradation, and algal degradation have been able to show satisfactory performance. In particular, microbial consortia and genetic modification of bacteria, fungi, and microalgae can also provide synergistic metabolic pathways that enhance the efficiency of antibiotic degradation. In addition, biogenic nanoparticles and enzyme-assisted degradation methods, such as laccases, can be advanced innovative approaches for antibiotic biodegradation. 

Summary

Antibiotic biodegradation has been a pivotal research focus due to increasing environmental pollution and the risk of antibiotic resistance. This topic is promising in decomposing antibiotics into compounds that are more tolerant of the environment. Although there has been progress in antibiotic biodegradation research, further studies should be conducted to overcome challenges such as the complexity of the compounds, antibiotic stability, antibiotic and gene resistance phenomena, and non-optimal environmental factors. 

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来源期刊
Current Pollution Reports
Current Pollution Reports Environmental Science-Water Science and Technology
CiteScore
12.10
自引率
1.40%
发文量
31
期刊介绍: Current Pollution Reports provides in-depth review articles contributed by international experts on the most significant developments in the field of environmental pollution.By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to identification, characterization, treatment, management of pollutants and much more.
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