念珠菌病:基于纳米技术的治疗方法

IF 3.6 4区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR
Luís André de Almeida Campos, Gabriel de Albuquerque Moura, Hanne Lazla Rafael de Queiroz Macêdo, Azael Francisco Silva Neto, Alessandra Silva Araújo, Isabella Macário Ferro Cavalcanti
{"title":"念珠菌病:基于纳米技术的治疗方法","authors":"Luís André de Almeida Campos,&nbsp;Gabriel de Albuquerque Moura,&nbsp;Hanne Lazla Rafael de Queiroz Macêdo,&nbsp;Azael Francisco Silva Neto,&nbsp;Alessandra Silva Araújo,&nbsp;Isabella Macário Ferro Cavalcanti","doi":"10.1007/s10876-025-02870-7","DOIUrl":null,"url":null,"abstract":"<div><p>Candidiasis is a fungal infection caused by several species of the <i>Candida</i> genus. These fungi are pleomorphic, and some of them make up the human microbiota, colonizing mucous areas and the skin. The interaction between the host immune system and the microbiota is crucial for maintaining homeostasis, but dysregulation can lead to fungal adaptation and pathogenesis. Candidiasis encompasses a diverse spectrum of clinical forms, including vulvovaginal, mucocutaneous and systemic infections. The need for early diagnosis, preventive measures and effective therapeutic approaches is urgent, considering the increase in resistant biofilm-producing fungi. In this sense, nanotechnology emerges as a promising therapeutic strategy against fungal infections caused by <i>Candida spp.</i> Nanostructures such as liposomes, polymeric nanoparticles and metallic nanoparticles, metal oxides, nanocomposites or quantum dots stand out for demonstrating advantages including maintaining the plasma concentration of active ingredients, reducing toxicity, increasing bioavailability and enhancing antifungal effects. This work focuses on <i>Candida</i> species of high priority for global public health, exploring how nanotechnology can improve current treatments, offering new avenues for the management of candidiasis.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"36 4","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Candidiasis: Therapeutic Approaches Based on Nanotechnology\",\"authors\":\"Luís André de Almeida Campos,&nbsp;Gabriel de Albuquerque Moura,&nbsp;Hanne Lazla Rafael de Queiroz Macêdo,&nbsp;Azael Francisco Silva Neto,&nbsp;Alessandra Silva Araújo,&nbsp;Isabella Macário Ferro Cavalcanti\",\"doi\":\"10.1007/s10876-025-02870-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Candidiasis is a fungal infection caused by several species of the <i>Candida</i> genus. These fungi are pleomorphic, and some of them make up the human microbiota, colonizing mucous areas and the skin. The interaction between the host immune system and the microbiota is crucial for maintaining homeostasis, but dysregulation can lead to fungal adaptation and pathogenesis. Candidiasis encompasses a diverse spectrum of clinical forms, including vulvovaginal, mucocutaneous and systemic infections. The need for early diagnosis, preventive measures and effective therapeutic approaches is urgent, considering the increase in resistant biofilm-producing fungi. In this sense, nanotechnology emerges as a promising therapeutic strategy against fungal infections caused by <i>Candida spp.</i> Nanostructures such as liposomes, polymeric nanoparticles and metallic nanoparticles, metal oxides, nanocomposites or quantum dots stand out for demonstrating advantages including maintaining the plasma concentration of active ingredients, reducing toxicity, increasing bioavailability and enhancing antifungal effects. This work focuses on <i>Candida</i> species of high priority for global public health, exploring how nanotechnology can improve current treatments, offering new avenues for the management of candidiasis.</p></div>\",\"PeriodicalId\":618,\"journal\":{\"name\":\"Journal of Cluster Science\",\"volume\":\"36 4\",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cluster Science\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10876-025-02870-7\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cluster Science","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10876-025-02870-7","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0

摘要

念珠菌病是由念珠菌属的几种真菌引起的真菌感染。这些真菌是多形性的,其中一些构成了人类的微生物群,定植在粘膜区域和皮肤上。宿主免疫系统和微生物群之间的相互作用对于维持体内平衡至关重要,但失调可能导致真菌适应和发病。念珠菌病包括多种临床形式,包括外阴阴道感染、粘膜皮肤感染和全身感染。考虑到耐药生物膜产生真菌的增加,迫切需要早期诊断,预防措施和有效的治疗方法。从这个意义上说,纳米技术作为治疗念珠菌引起的真菌感染的一种有前景的治疗策略,纳米结构如脂质体、聚合物纳米粒子和金属纳米粒子、金属氧化物、纳米复合材料或量子点等,在维持活性成分的血浆浓度、降低毒性、提高生物利用度和增强抗真菌作用等方面表现出突出的优势。这项工作的重点是全球公共卫生高度优先的念珠菌物种,探索纳米技术如何改善现有的治疗方法,为念珠菌病的管理提供新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Candidiasis: Therapeutic Approaches Based on Nanotechnology

Candidiasis is a fungal infection caused by several species of the Candida genus. These fungi are pleomorphic, and some of them make up the human microbiota, colonizing mucous areas and the skin. The interaction between the host immune system and the microbiota is crucial for maintaining homeostasis, but dysregulation can lead to fungal adaptation and pathogenesis. Candidiasis encompasses a diverse spectrum of clinical forms, including vulvovaginal, mucocutaneous and systemic infections. The need for early diagnosis, preventive measures and effective therapeutic approaches is urgent, considering the increase in resistant biofilm-producing fungi. In this sense, nanotechnology emerges as a promising therapeutic strategy against fungal infections caused by Candida spp. Nanostructures such as liposomes, polymeric nanoparticles and metallic nanoparticles, metal oxides, nanocomposites or quantum dots stand out for demonstrating advantages including maintaining the plasma concentration of active ingredients, reducing toxicity, increasing bioavailability and enhancing antifungal effects. This work focuses on Candida species of high priority for global public health, exploring how nanotechnology can improve current treatments, offering new avenues for the management of candidiasis.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Cluster Science
Journal of Cluster Science 化学-无机化学与核化学
CiteScore
6.70
自引率
0.00%
发文量
166
审稿时长
3 months
期刊介绍: The journal publishes the following types of papers: (a) original and important research; (b) authoritative comprehensive reviews or short overviews of topics of current interest; (c) brief but urgent communications on new significant research; and (d) commentaries intended to foster the exchange of innovative or provocative ideas, and to encourage dialogue, amongst researchers working in different cluster disciplines.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信