MEF2C网络在心脏管发展中的应用

IF 7.7 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2025-09-25 DOI:10.1101/gad.353315.125

Hassan Abdulrazzak, Mark Mercola

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引用次数: 0

摘要

心脏的形成取决于转录调节因子的精细调节活动，但它们控制的网络直到现在才被定义。在这一期的《基因与发育》杂志上，Muncie-Vasik及其同事（doi:10.1101/gad.352889.125）分析了MEF2C的作用，MEF2C是心脏形成的关键驱动因素。通过表征MEF2C对mRNA谱和染色质结构的时间效应，研究人员通过计算重建了下游基因调控网络，结果表明，该网络对形成流入道、腔室和流出道的不同心脏管段具有显著的特异性。结果包括心脏形成的网络逻辑的极细粒度视图。

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MEF2C networks in heart tube development

Heart formation depends on the finely tuned activity of transcriptional regulators, yet the networks they control are only now being defined. In this issue of Genes & Development, Muncie-Vasik and colleagues (doi:10.1101/gad.352889.125) analyzed the role of MEF2C, which is a key driver of heart formation. By characterizing MEF2C's temporal effects on mRNA profiles and chromatin structure, the investigators computationally reconstructed downstream gene regulatory networks, which turned out to be remarkably specific for the different heart tube segments that form the inflow tract, chambers, and outflow tract. The results comprise an extremely fine-grained view of the network logic of heart formation.

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).