钯催化四组分自由基羰基化反应构建苯并呋喃酰胺衍生物

IF 2.7 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-09-25 DOI:10.1002/ejoc.202500539

Xiao-Jun Liu, Xian-Ming Gao, Dong-Yu Miao, Ming Li, Shun-Xi Li, Dong-Pin Chen, Yi-feng Qiu, Zheng-Jun Quan, Xi-Cun Wang, Yong-Min Liang

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引用次数: 0

摘要

报道了一种新的钯催化的四组分自由基串联环化- 1,6-炔与苯胺、一氧化碳和二氟碘乙酸乙酯的羰基化反应。这种方法促进了涉及串联1,2-双键迁移的多组分反应，从而允许高效合成烷基酰胺取代的苯并呋喃酰胺衍生物。该策略具有底物范围广、键迁移重排效率高、组分添加顺序选择性可控等特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Palladium-Catalyzed Four-Component Radical Carbonylation Reaction for the Construction of Benzofuranamide Derivativesitle

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Palladium-Catalyzed Four-Component Radical Carbonylation Reaction for the Construction of Benzofuranamide Derivativesitle

A novel palladium-catalyzed four-component radical tandem cyclization-carbonylation of 1,6-enynes with aniline, carbon monoxide, and ethyl difluoroiodoacetate is reported. This approach facilitates a multicomponent reaction involving tandem 1,2-double bond migration, thereby allowing the efficient synthesis of alkylamide-substituted benzofuranamide derivatives. The proposed strategy demonstrates a broad substrate scope, high efficiency in bond migratory-rearrangement, and controllable selectivity in the order of component addition.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.