Oscar Moreno, Nathaniel Parchment, Kate Micallef, Sabrina Rocco, Amber Clay, Catherine Luke, Kiran Kumar, Jorge H Ulloa, Thomas Wakefield, Andrea Obi, Peter Henke
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Predictive Biomarkers for Post-thrombotic Syndrome (PTS).
Post-thrombotic syndrome (PTS) is a long-term sequela of Deep venous thrombosis (DVT). This review summarizes the best currently available biomarker candidates to identify high-risk progression patients. We examined indexed literature, including clinical studies and review articles, to identify biomarkers indicating the progression of DVT to PTS. Among the most studied biomarkers, associations between PTS and ICAM-1 and IL-10 were consistently found to be associated with PTS development, whereas D-Dimer, CRP, and IL-6 showed inconsistent results. Other less-studied biomarkers, including cell adhesion molecules, adipokines, thrombotic/fibrinolytic molecules, and novel imaging modalities, have been associated with PTS. Further clinical research on PTS biomarkers is warranted with standardized study designs to compare outcomes. A panel of biomarkers adjusted by age and BMI, including inflammatory (IL-10), coagulation (D-dimer), adhesion (ICAM-1), remodeling (MMP-1/8), and metabolic molecules (adiponectin/leptin) in conjunction with imaging, is recommended for future studies.
期刊介绍：
Journal of Vascular Surgery: Venous and Lymphatic Disorders is one of a series of specialist journals launched by the Journal of Vascular Surgery. It aims to be the premier international Journal of medical, endovascular and surgical management of venous and lymphatic disorders. It publishes high quality clinical, research, case reports, techniques, and practice manuscripts related to all aspects of venous and lymphatic disorders, including malformations and wound care, with an emphasis on the practicing clinician. The journal seeks to provide novel and timely information to vascular surgeons, interventionalists, phlebologists, wound care specialists, and allied health professionals who treat patients presenting with vascular and lymphatic disorders. As the official publication of The Society for Vascular Surgery and the American Venous Forum, the Journal will publish, after peer review, selected papers presented at the annual meeting of these organizations and affiliated vascular societies, as well as original articles from members and non-members.
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