Fangfang Huang, Huizhen Li, Haizhen You, Yuantao Su, Huijuan Peng, Wenchong Du, Jing Hua
{"title":"发育协调障碍的表观遗传修饰:DNA甲基化与运动表现之间的关系。","authors":"Fangfang Huang, Huizhen Li, Haizhen You, Yuantao Su, Huijuan Peng, Wenchong Du, Jing Hua","doi":"10.3389/fcell.2025.1647365","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Developmental Coordination Disorder (DCD) is a common neurodevelopmental condition characterized by impaired motor coordination. However, the biological mechanisms underlying DCD remain largely unclear. This study aimed to investigate the potential role of DNA methylation in the pathogenesis of DCD.</p><p><strong>Methods: </strong>Genome-wide DNA methylation analysis was conducted using peripheral blood samples from children with and without DCD. Forty-two key differentially methylated probes (DMPs) were selected for targeted validation using MethylTarget™ sequencing.</p><p><strong>Results: </strong>A total of 416 DMPs were detected. Using the Bumphunter and ProbeLasso algorithms, 48 and 22 differentially methylated regions (DMRs) were identified, respectively. Among the key DMPs, methylation levels at cg18187326 (<i>FAM45A</i>) and cg11968956 (<i>FAM184A</i>) were significantly associated with both total motor and gross motor scores. In addition, cg03597174 (<i>SEZ6</i>) was negatively associated, while cg05986449 (<i>GPD2</i>) was positively associated with gross motor function.</p><p><strong>Conclusion: </strong>These findings provide preliminary evidence that specific DNA methylation alterations may influence early motor development and potentially contribute to the pathogenesis of DCD. DNA methylation markers may serve as novel biomarkers for early diagnosis and targeted intervention in children with DCD.</p>","PeriodicalId":12448,"journal":{"name":"Frontiers in Cell and Developmental Biology","volume":"13 ","pages":"1647365"},"PeriodicalIF":4.6000,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454365/pdf/","citationCount":"0","resultStr":"{\"title\":\"Epigenetic modifications in developmental coordination disorder: association between DNA methylation and motor performance.\",\"authors\":\"Fangfang Huang, Huizhen Li, Haizhen You, Yuantao Su, Huijuan Peng, Wenchong Du, Jing Hua\",\"doi\":\"10.3389/fcell.2025.1647365\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Developmental Coordination Disorder (DCD) is a common neurodevelopmental condition characterized by impaired motor coordination. However, the biological mechanisms underlying DCD remain largely unclear. This study aimed to investigate the potential role of DNA methylation in the pathogenesis of DCD.</p><p><strong>Methods: </strong>Genome-wide DNA methylation analysis was conducted using peripheral blood samples from children with and without DCD. Forty-two key differentially methylated probes (DMPs) were selected for targeted validation using MethylTarget™ sequencing.</p><p><strong>Results: </strong>A total of 416 DMPs were detected. Using the Bumphunter and ProbeLasso algorithms, 48 and 22 differentially methylated regions (DMRs) were identified, respectively. Among the key DMPs, methylation levels at cg18187326 (<i>FAM45A</i>) and cg11968956 (<i>FAM184A</i>) were significantly associated with both total motor and gross motor scores. In addition, cg03597174 (<i>SEZ6</i>) was negatively associated, while cg05986449 (<i>GPD2</i>) was positively associated with gross motor function.</p><p><strong>Conclusion: </strong>These findings provide preliminary evidence that specific DNA methylation alterations may influence early motor development and potentially contribute to the pathogenesis of DCD. DNA methylation markers may serve as novel biomarkers for early diagnosis and targeted intervention in children with DCD.</p>\",\"PeriodicalId\":12448,\"journal\":{\"name\":\"Frontiers in Cell and Developmental Biology\",\"volume\":\"13 \",\"pages\":\"1647365\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-09-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454365/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Cell and Developmental Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.3389/fcell.2025.1647365\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Cell and Developmental Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3389/fcell.2025.1647365","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Epigenetic modifications in developmental coordination disorder: association between DNA methylation and motor performance.
Objective: Developmental Coordination Disorder (DCD) is a common neurodevelopmental condition characterized by impaired motor coordination. However, the biological mechanisms underlying DCD remain largely unclear. This study aimed to investigate the potential role of DNA methylation in the pathogenesis of DCD.
Methods: Genome-wide DNA methylation analysis was conducted using peripheral blood samples from children with and without DCD. Forty-two key differentially methylated probes (DMPs) were selected for targeted validation using MethylTarget™ sequencing.
Results: A total of 416 DMPs were detected. Using the Bumphunter and ProbeLasso algorithms, 48 and 22 differentially methylated regions (DMRs) were identified, respectively. Among the key DMPs, methylation levels at cg18187326 (FAM45A) and cg11968956 (FAM184A) were significantly associated with both total motor and gross motor scores. In addition, cg03597174 (SEZ6) was negatively associated, while cg05986449 (GPD2) was positively associated with gross motor function.
Conclusion: These findings provide preliminary evidence that specific DNA methylation alterations may influence early motor development and potentially contribute to the pathogenesis of DCD. DNA methylation markers may serve as novel biomarkers for early diagnosis and targeted intervention in children with DCD.
期刊介绍:
Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board.
The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology.
With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.