体重减轻先于糖尿病发病的个体特征:一项基于日本健康检查的回顾性、观察性、纵向队列研究

IF 2.1 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Masataka Shikata, Makito Oku, Shion Fukuhara, Ryo Ito, Takayuki Haruki, Keiichi Ueda, Iwao Kimura, Tsuyoshi Teramoto, Daisuke Chujo, Minoru Iwata, Takashi Yamagami, Yoshiki Nagata, Makoto Kadowaki, Kazuyuki Tobe
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引用次数: 0

摘要

众所周知,东亚人患糖尿病的体重比白种人低,这可能是因为疾病发展的机制不同。本研究旨在评估日本人群中两种亚型个体(肥胖和非肥胖)体重转变导致糖尿病发病的变化。我们利用日本9260名参与者的健康检查数据进行了一项回顾性、观察性、纵向队列研究。在观察期开始的三年内患糖尿病的个体被排除在外。在参与者中,61.4%是男性,259人患有糖尿病。在肥胖组(体重指数[BMI]≥25 kg/m2),平均BMI在糖尿病发病前升高,随后下降。相反,在非肥胖组(BMI为2)中,平均BMI在糖尿病发病前下降,然后稳定下来。值得注意的是,与糖尿病发病前BMI变化≥0.15 kg/m2的参与者相比,非肥胖组中每年BMI变化≤-0.15 kg/m2的参与者数量更多(p = 0.003)。我们的研究结果表明,在非肥胖组中,体重减轻先于糖尿病的发病。我们建议,不符合糖尿病标准的血糖水平升高的非肥胖个体应被视为糖尿病发展的高危人群。因此,必须识别这些个体,并提供不以减肥为重点的生活方式指导,以预防糖尿病的发生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characterization of individuals in whom body weight loss precedes diabetes onset: a retrospective, observational, longitudinal cohort study based on health checkup in Japan.

East Asians are known to develop diabetes mellitus at a lower body weight than Caucasians, potentially because of the different mechanisms underlying disease development. This study aimed to evaluate the variation in weight transition leading to diabetes onset in two subtypes of individuals (obese and non-obese) in a Japanese population. We conducted a retrospective, observational, longitudinal cohort study using health checkup data from 9, 260 participants in Japan. Individuals who developed diabetes within three years of the start of the observation period were excluded. Among the participants, 61.4% were men, and 259 developed diabetes. In the obesity group (body mass index [BMI] ≥25 kg/m2), the average BMI increased prior to the diabetes onset and subsequently decreased. Conversely, in the non-obesity group (BMI <25 kg/m2), the average BMI decreased and then stabilized before the onset of diabetes. Notably, a greater number of participants in the non-obesity group exhibited a BMI change of ≤-0.15 kg/m2 per year compared with those with a BMI change of ≥0.15 kg/m2 per year before diabetes onset (p = 0.003). Our findings indicate that body weight loss precedes the onset of diabetes in the non-obesity group. We recommend that non-obese individuals with elevated blood glucose levels who do not meet the criteria for diabetes should be considered a high-risk group for diabetes development. Therefore, it is imperative to identify these individuals and provide lifestyle guidance that does not focus on weight loss to prevent the onset of diabetes.

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来源期刊
Endocrine journal
Endocrine journal 医学-内分泌学与代谢
CiteScore
4.30
自引率
5.00%
发文量
224
审稿时长
1.5 months
期刊介绍: Endocrine Journal is an open access, peer-reviewed online journal with a long history. This journal publishes peer-reviewed research articles in multifaceted fields of basic, translational and clinical endocrinology. Endocrine Journal provides a chance to exchange your ideas, concepts and scientific observations in any area of recent endocrinology. Manuscripts may be submitted as Original Articles, Notes, Rapid Communications or Review Articles. We have a rapid reviewing and editorial decision system and pay a special attention to our quick, truly scientific and frequently-citable publication. Please go through the link for author guideline.
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