神经递质胺与CO2在水中的结构变化：共价结合氨基甲酸的形成。

IF 1.3 4区医学 Q4 CHEMISTRY, MEDICINAL

Chemical & pharmaceutical bulletin Pub Date : 2025-01-01 DOI:10.1248/cpb.c25-00463

Keitaro Shiota, Ryo Murakami, Fuyuhiko Inagaki

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引用次数: 0

摘要

结构转化改变了生物反应的活性。苯乙胺、酪胺、多巴胺、色胺、血清素和组胺等神经递质aralkylamines能够吸收空气中的CO2，并且在D2O溶液中证实了CO2衍生的碳与几种胺的α-氢之间的异核多键连接（HMBC）相关性。用TMSCHN2在水中从苯乙胺和CO2中分离氨基甲酸甲酯，也支持了氨基甲酸在含CO2的胺水溶液中形成共价结合的氨基甲酸。因此，我们认为体内产生的CO2会与神经递质胺反应形成共价结合的氨基甲酸，从而影响生物反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Structural Change of Neurotransmitter Amine with CO₂ in Water: Formation of Covalently Bound Carbamic Acid.

Structural transformation changes the activity of biological reactions. Neurotransmitter aralkylamines, such as phenethylamine, tyramine, dopamine, tryptamine, serotonin, and histamine, absorb aerial CO₂, and heteronuclear multiple bond connectivity (HMBC) correlations between the carbon derived from CO₂ and the α-hydrogen of the several amines were confirmed in the D₂O solution. The isolation of methyl carbamate from phenethylamine and CO₂ in water with TMSCHN₂ also supported the formation of covalently bound carbamic acid in the amine aqueous solution containing CO₂. Therefore, it is suggested that CO₂ produced in the body would react with neurotransmitter amines to form covalently bound carbamic acid, which might affect biological reactions.

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来源期刊

Chemical & pharmaceutical bulletin 医学-化学综合

CiteScore

3.20

自引率

5.90%

发文量

132

审稿时长

1.7 months

期刊介绍： The CPB covers various chemical topics in the pharmaceutical and health sciences fields dealing with biologically active compounds, natural products, and medicines, while BPB deals with a wide range of biological topics in the pharmaceutical and health sciences fields including scientific research from basic to clinical studies. For details of their respective scopes, please refer to the submission topic categories below. Topics: Organic chemistry In silico science Inorganic chemistry Pharmacognosy Health statistics Forensic science Biochemistry Pharmacology Pharmaceutical care and science Medicinal chemistry Analytical chemistry Physical pharmacy Natural product chemistry Toxicology Environmental science Molecular and cellular biology Biopharmacy and pharmacokinetics Pharmaceutical education Chemical biology Physical chemistry Pharmaceutical engineering Epidemiology Hygiene Regulatory science Immunology and microbiology Clinical pharmacy Miscellaneous.