姜黄素通过调控p300表达和蛋白乳酸化干预败血症相关性急性肾损伤。

IF 2.7 4区医学 Q3 IMMUNOLOGY

BMC Immunology Pub Date : 2025-09-24 DOI:10.1186/s12865-025-00750-3

Mengyuan Luo, Quanmang Zhu, Guangcai Xu, Dan Liu, Jiajun Xiao, Qiqing Shi

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引用次数: 0

摘要

本研究探讨了姜黄素在脓毒症相关急性肾损伤（SA-AKI）中的保护作用及其机制。通过盲肠结扎和穿刺（CLP）模型模拟SA-AKI，我们的研究结果表明姜黄素显著降低血清肌酐和尿素氮水平，减轻小管损伤和炎症，提高细胞活性，抑制细胞凋亡。进一步分析发现，姜黄素抑制p300的表达，降低肾组织中蛋白质的乳酸化修饰，从而发挥抗炎和抗氧化作用。这些发现提示姜黄素在预防和治疗SA-AKI方面可能具有潜在的治疗价值。

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Intervention effect of curcumin on sepsis-associated acute kidney injury via regulation of p300 expression and protein lactylation.

This study investigates the protective effects and underlying mechanisms of curcumin in sepsis-associated acute kidney injury (SA-AKI). Using a cecal ligation and puncture (CLP) model to simulate SA-AKI, our results demonstrate that curcumin significantly reduced serum creatinine and urea nitrogen levels, alleviated tubular damage and inflammation, improved cellular activity, and inhibited apoptosis. Further analysis revealed that curcumin inhibited the expression of p300 and decreased protein lactylation modification in renal tissue, thereby exerting anti-inflammatory and antioxidant effects. These findings suggest that curcumin may have potential therapeutic value for the prevention and treatment of SA-AKI.

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来源期刊

BMC Immunology 医学-免疫学

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： BMC Immunology is an open access journal publishing original peer-reviewed research articles in molecular, cellular, tissue-level, organismal, functional, and developmental aspects of the immune system as well as clinical studies and animal models of human diseases.