电子顺磁共振证明吲哚菁绿产生单线态氧。

IF 2.2 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. General subjects Pub Date : 2025-09-22 DOI:10.1016/j.bbagen.2025.130861

Magdalena Szpunar , David Aebisher , Bogumił Cieniek , Ireneusz Stefaniuk , Łukasz Dubiel , Andrzej Wal

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引用次数: 0

摘要

吲哚菁绿（ICG）是一种众所周知的用于心血管荧光成像的染料，也是一种潜在的光动力治疗光敏剂。利用电子顺磁共振（EPR），我们已经证明了ICG水溶液的照明导致单线态氧的产生。选择性自旋阱的使用使单线态氧生成速率得以确定，这提供了ICG经历II型光敏化的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Evidence for singlet oxygen production from indocyanine green by electron paramagnetic resonance

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Evidence for singlet oxygen production from indocyanine green by electron paramagnetic resonance

Indocyanine green (ICG) is a well-known dye used for cardiovascular fluorescence imaging in medicine and a potential photosensitizer for photodynamic therapy. Using electron paramagnetic resonance (EPR), we have shown that illumination of aqueous solutions of ICG leads to the generation of singlet oxygen. The use of a selective spin trap allowed for the rate of singlet oxygen generation to be determined which provides evidence that ICG undergoes Type II photosensitization.

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来源期刊

Biochimica et biophysica acta. General subjects 生物-生化与分子生物学

CiteScore

6.40

自引率

0.00%

发文量

139

审稿时长

30 days

期刊介绍： BBA General Subjects accepts for submission either original, hypothesis-driven studies or reviews covering subjects in biochemistry and biophysics that are considered to have general interest for a wide audience. Manuscripts with interdisciplinary approaches are especially encouraged.