当摇晃而不是搅拌时的SuFEx反应

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-09-26 DOI:10.1002/adsc.70081

Yaxin Wang , Zitong Hao , Muhammad Islam , Yumei Zhu , Yang Chao , Sidharam P. Pujari , Hongxia Zhao , Han Zuilhof

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引用次数: 0

摘要

点击反应显示了许多更可持续的化学转化所需的目标。然而，在确定反应对环境的影响时，所用的溶剂是一个经常被忽视的方面。本文首次开发了一种机械化学方法，用于磺酰氟与多种酚类化合物的高效无溶剂SuFEx反应。在概述了优化过程后，得出了一种易于使用且鲁棒性强的方法。这种方法的广泛范围得到了证明，并通过应用于一系列具有其他功能的天然酚，以及几克级的合成，证明了这种潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

SuFEx Reactions When Shaken Not Stirred

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SuFEx Reactions When Shaken Not Stirred

Click reactions display many of the goals desired for more sustainable chemical conversions. Yet, the solvent used is an often overlooked aspect in determining the environmental impact of reactions. In the current paper, the first mechanochemical method is developed for the efficient and solvent‐free SuFEx reaction of sulfonyl fluorides with a wide range of phenols. After outlining the optimization process, which yields an easy‐to‐use and robust method. The broad scope of this approach is evidenced, and demonstrate this potential via the application to a range of natural phenols that also display other functionalities, and several gram‐scale syntheses.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.