肝病和心肝综合征患者的麻醉评估和术后策略

IF 0.8 Q3 ANESTHESIOLOGY
A. Espinosa , J. Ripolles Melchor , M. Jain , R. Navarro-Perez , Y.A. Shadad , A. Malvido , A. Abad Gurumeta , R. Alharbi
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引用次数: 0

摘要

由于肝功能障碍和心功能障碍之间复杂的相互作用,肝功能障碍综合征(CHS)在围手术期治疗中提出了重大挑战。CHS与心肾综合征类似,包括肝脏和心血管疾病相互加剧的各种情况。慢性肝病、肝硬化或心力衰竭患者围手术期的发病率和死亡率往往会增加,因此需要有针对性的麻醉策略。全面了解CHS的病理生理是至关重要的,因为它可以为风险评估和围手术期管理提供指导。通常使用的风险分层工具如Child-Pugh和MELD评分,但它们在充分捕捉围手术期风险方面存在局限性。更新后的STS 2024模型包括肝脏特异性参数,提高了心脏手术的风险预测。此外,VOCAL-Penn评分弥补了传统风险模型的不足,为晚期肝病患者提供了更准确的评估。围手术期管理的重点是尽量减少血流动力学压力和避免肝脏代谢的药物。瑞芬太尼、阿曲库铵和艾司洛尔等药物因其肝脏代谢最低而被首选。血管加压素,如特利加压素和血管加压素,靶向内脏循环,改善这些患者的血液动力学。在增强术后恢复(ERAS)框架下,优化营养和液体管理对于减少围手术期并发症至关重要。对CHS患者的有效管理需要多学科方法,包括综合风险评估和个体化麻醉策略。这种方法通过减少高危人群的围手术期并发症和死亡率来改善预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluación anestésica y estrategias perioperatorias en los pacientes con hepatopatía y síndrome cardiohepático
Cardiohepatic syndrome (CHS) presents a significant challenge in perioperative management due to the complex interaction between liver and heart dysfunction. CHS, analogous to cardiorenal syndrome, encompasses various conditions where hepatic and cardiovascular pathologies exacerbate one another. Patients with chronic liver disease, cirrhosis, or heart failure often exhibit increased perioperative morbidity and mortality, necessitating tailored anesthetic strategies. A comprehensive understanding of CHS pathophysiology is crucial, as it informs risk assessment and guides perioperative management. Risk stratification tools such as the Child-Pugh and MELD scores are commonly used, but they have limitations in fully capturing perioperative risks. The updated STS 2024 model includes liver-specific parameters, improving risk prediction in cardiac surgeries. Additionally, the VOCAL-Penn score addresses gaps in traditional risk models, providing a more accurate assessment for patients with advanced liver disease.
Perioperative management focuses on minimizing hemodynamic stress and avoiding drugs metabolized by the liver. Agents like Remifentanil, Atracurium, and Esmolol are preferred for their minimal hepatic metabolism. Vasopressors such as terlipressin and vasopressin, which target the splanchnic circulation, improve hemodynamics in these patients. Within the Enhanced Recovery After Surgery (ERAS) framework, optimizing nutrition and fluid management is essential for reducing perioperative complications. Effective management of patients with CHS requires a multidisciplinary approach that integrates comprehensive risk assessment and individualized anesthetic strategies. This approach improves outcomes by reducing perioperative complications and mortality in this high-risk population.
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来源期刊
CiteScore
1.80
自引率
15.40%
发文量
113
审稿时长
82 days
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