Dayae Kang, , , Ji Ha Lee*, , , Azeem Ullah, , , Gopiraman Mayakrishnan, , , Chieri Inada, , , Tomoki Nishimura, , , Jungsoon Lee*, , and , Ick Soo Kim*,
{"title":"氧化铁负载醋酸纤维素纳米纤维对阿霉素局部释放的ph响应动力学研究","authors":"Dayae Kang, , , Ji Ha Lee*, , , Azeem Ullah, , , Gopiraman Mayakrishnan, , , Chieri Inada, , , Tomoki Nishimura, , , Jungsoon Lee*, , and , Ick Soo Kim*, ","doi":"10.1021/acsapm.5c02631","DOIUrl":null,"url":null,"abstract":"<p >Cellulose acetate (CA) nanofibers incorporating Fe<sub>2</sub>O<sub>3</sub> and Fe<sub>3</sub>O<sub>4</sub> nanoparticles were fabricated via electrospinning for the pH-responsive delivery of doxorubicin (DOX). The nanofiber morphology, surface wettability, chemical composition, and crystallinity were analyzed using FE-SEM, water contact angle measurements, FT-IR spectroscopy, and XRD, respectively. The incorporation of iron oxide nanoparticles altered the fiber diameter while maintaining the overall structural integrity of the CA matrix. The incorporation of iron oxide significantly enhanced DOX loading efficiency, with 2 wt % Fe<sub>3</sub>O<sub>4</sub> nanofibers achieving the highest loading capacity. Drug release studies revealed sustained DOX release under physiological conditions (pH 7.2), governed by diffusion mechanisms, and accelerated release under acidic conditions (pH 5.0), associated with polymer relaxation and erosion. Nanofibers containing 2 wt % Fe<sub>2</sub>O<sub>3</sub> and 2 wt % Fe<sub>3</sub>O<sub>4</sub> exhibited optimal pH-responsive release profiles, maintained structural stability, and demonstrated favorable morphology. Cytotoxicity assays using CT26 cells confirmed the biological activity of DOX released from the nanofibers, demonstrating significant cancer cell suppression under tumor-mimicking acidic conditions.</p>","PeriodicalId":7,"journal":{"name":"ACS Applied Polymer Materials","volume":"7 18","pages":"12732–12742"},"PeriodicalIF":4.7000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tunable pH-Responsive Release Kinetics of Doxorubicin from Iron Oxide-Loaded Cellulose Acetate Nanofibers for Localized Drug Delivery\",\"authors\":\"Dayae Kang, , , Ji Ha Lee*, , , Azeem Ullah, , , Gopiraman Mayakrishnan, , , Chieri Inada, , , Tomoki Nishimura, , , Jungsoon Lee*, , and , Ick Soo Kim*, \",\"doi\":\"10.1021/acsapm.5c02631\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Cellulose acetate (CA) nanofibers incorporating Fe<sub>2</sub>O<sub>3</sub> and Fe<sub>3</sub>O<sub>4</sub> nanoparticles were fabricated via electrospinning for the pH-responsive delivery of doxorubicin (DOX). The nanofiber morphology, surface wettability, chemical composition, and crystallinity were analyzed using FE-SEM, water contact angle measurements, FT-IR spectroscopy, and XRD, respectively. The incorporation of iron oxide nanoparticles altered the fiber diameter while maintaining the overall structural integrity of the CA matrix. The incorporation of iron oxide significantly enhanced DOX loading efficiency, with 2 wt % Fe<sub>3</sub>O<sub>4</sub> nanofibers achieving the highest loading capacity. Drug release studies revealed sustained DOX release under physiological conditions (pH 7.2), governed by diffusion mechanisms, and accelerated release under acidic conditions (pH 5.0), associated with polymer relaxation and erosion. Nanofibers containing 2 wt % Fe<sub>2</sub>O<sub>3</sub> and 2 wt % Fe<sub>3</sub>O<sub>4</sub> exhibited optimal pH-responsive release profiles, maintained structural stability, and demonstrated favorable morphology. Cytotoxicity assays using CT26 cells confirmed the biological activity of DOX released from the nanofibers, demonstrating significant cancer cell suppression under tumor-mimicking acidic conditions.</p>\",\"PeriodicalId\":7,\"journal\":{\"name\":\"ACS Applied Polymer Materials\",\"volume\":\"7 18\",\"pages\":\"12732–12742\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2025-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Polymer Materials\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsapm.5c02631\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Polymer Materials","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsapm.5c02631","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Tunable pH-Responsive Release Kinetics of Doxorubicin from Iron Oxide-Loaded Cellulose Acetate Nanofibers for Localized Drug Delivery
Cellulose acetate (CA) nanofibers incorporating Fe2O3 and Fe3O4 nanoparticles were fabricated via electrospinning for the pH-responsive delivery of doxorubicin (DOX). The nanofiber morphology, surface wettability, chemical composition, and crystallinity were analyzed using FE-SEM, water contact angle measurements, FT-IR spectroscopy, and XRD, respectively. The incorporation of iron oxide nanoparticles altered the fiber diameter while maintaining the overall structural integrity of the CA matrix. The incorporation of iron oxide significantly enhanced DOX loading efficiency, with 2 wt % Fe3O4 nanofibers achieving the highest loading capacity. Drug release studies revealed sustained DOX release under physiological conditions (pH 7.2), governed by diffusion mechanisms, and accelerated release under acidic conditions (pH 5.0), associated with polymer relaxation and erosion. Nanofibers containing 2 wt % Fe2O3 and 2 wt % Fe3O4 exhibited optimal pH-responsive release profiles, maintained structural stability, and demonstrated favorable morphology. Cytotoxicity assays using CT26 cells confirmed the biological activity of DOX released from the nanofibers, demonstrating significant cancer cell suppression under tumor-mimicking acidic conditions.
期刊介绍：
ACS Applied Polymer Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics, and biology relevant to applications of polymers.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates fundamental knowledge in the areas of materials, engineering, physics, bioscience, polymer science and chemistry into important polymer applications. The journal is specifically interested in work that addresses relationships among structure, processing, morphology, chemistry, properties, and function as well as work that provide insights into mechanisms critical to the performance of the polymer for applications.
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