皮肤成纤维细胞在疾病中塑造出不同的基质和免疫龛。

IF 27.6 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-09-24 DOI:10.1038/s41590-025-02266-9

引用次数: 0

摘要

我们的研究对健康和疾病的皮肤成纤维细胞进行了定义和空间映射。我们根据23种皮肤病中成纤维细胞亚型与疤痕风险的关联对其进行分类，并进行跨组织比较以确定共享的成纤维细胞状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Skin fibroblasts sculpt distinct stromal and immune niches across diseases

查看原文本刊更多论文

Skin fibroblasts sculpt distinct stromal and immune niches across diseases

Our study defines and spatially maps skin fibroblasts in both health and disease. We categorize fibroblast subtypes based on their association with scarring risk across 23 skin diseases and perform cross-tissue comparisons to identify shared fibroblast states.

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.