Muzaffer Aslan, Dogac Oksen, Yunus Emre Yavuz, Çağdaş Kaynak
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Despite their benefits, the oxidative stress response triggered by these interventions and its implications for vascular healing remain unclear.</p>\n </section>\n \n <section>\n \n <h3> Aims</h3>\n \n <p>This study aims to compare the oxidative stress burden associated with DES and DCB by evaluating changes in plasma total peroxidase (TP) levels over time.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This observational, comparative study included 110 patients (60 DES and 50 DCB) who underwent PCI for stable coronary artery disease. TP levels were measured pre-procedure, 24 h postprocedure, and 1 month after PCI. Statistical comparisons were used to determine significant differences in oxidative stress between the two groups over time.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Preoperative TP levels were comparable between the DES and DCB groups (431.00 ± 4.56 vs. 436.50 ± 4.14 µmol/L, <i>p</i> = 0.110). At 24 h post-PCI, TP levels increased significantly in both groups (DES: 449.50 ± 6.51 µmol/L, DCB: 442.50 ± 4.14 µmol/L), with a greater rise observed in the DES group, though not statistically significant (<i>p</i> = 0.42). At the 1-month follow-up, TP levels decreased significantly below baseline in both groups, with a more pronounced reduction in the DCB group (398.50 ± 4.14 vs. 406.50 ± 4.51 µmol/L, <i>p</i> = 0.11).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>This study reveals that both DES and DCB procedures trigger an initial rise in oxidative stress markers, emphasizing their acute vascular impact. Intriguingly, although not statistically significant, the DCB group demonstrated a trend toward a more rapid decline in oxidative stress at 1 month post-PCI. These preliminary findings highlight the potential of DCBs to foster quicker vascular recovery, warranting further investigation into their long-term clinical advantages.</p>\n </section>\n </div>","PeriodicalId":9650,"journal":{"name":"Catheterization and Cardiovascular Interventions","volume":"106 4","pages":"2791-2798"},"PeriodicalIF":1.9000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of Oxidative Stress Effects Between Drug-Eluting Stents and Drug-Coated Balloons: Insights Into Vascular Response and Clinical Implications\",\"authors\":\"Muzaffer Aslan, Dogac Oksen, Yunus Emre Yavuz, Çağdaş Kaynak\",\"doi\":\"10.1002/ccd.70209\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Percutaneous coronary intervention (PCI) has evolved with the development of drug-eluting stents (DES) and drug-coated balloons (DCB), both of which play a crucial role in reducing restenosis and major adverse cardiovascular events (MACE). 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At 24 h post-PCI, TP levels increased significantly in both groups (DES: 449.50 ± 6.51 µmol/L, DCB: 442.50 ± 4.14 µmol/L), with a greater rise observed in the DES group, though not statistically significant (<i>p</i> = 0.42). At the 1-month follow-up, TP levels decreased significantly below baseline in both groups, with a more pronounced reduction in the DCB group (398.50 ± 4.14 vs. 406.50 ± 4.51 µmol/L, <i>p</i> = 0.11).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>This study reveals that both DES and DCB procedures trigger an initial rise in oxidative stress markers, emphasizing their acute vascular impact. Intriguingly, although not statistically significant, the DCB group demonstrated a trend toward a more rapid decline in oxidative stress at 1 month post-PCI. 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引用次数: 0
摘要
背景：经皮冠状动脉介入治疗（PCI）随着药物洗脱支架（DES）和药物包被球囊（DCB）的发展而发展，两者在减少再狭窄和主要不良心血管事件（MACE）方面都起着至关重要的作用。尽管有这些益处，但这些干预措施引发的氧化应激反应及其对血管愈合的影响尚不清楚。目的：本研究旨在通过评估血浆总过氧化物酶（TP）水平随时间的变化，比较DES和DCB相关的氧化应激负担。方法：本观察性比较研究纳入110例（60例DES和50例DCB）因稳定冠状动脉疾病行PCI治疗的患者。测量术前、术后24小时和PCI术后1个月的TP水平。统计比较用于确定两组之间氧化应激随时间的显著差异。结果：DES组和DCB组术前TP水平具有可比性（431.00±4.56 vs 436.50±4.14µmol/L, p = 0.110）。pci术后24 h，两组TP水平均显著升高（DES: 449.50±6.51µmol/L, DCB: 442.50±4.14µmol/L）， DES组升高幅度更大，但无统计学意义（p = 0.42）。在1个月的随访中，两组TP水平均显著低于基线水平，DCB组降低更为明显（398.50±4.14 vs 406.50±4.51µmol/L, p = 0.11）。结论：本研究表明，DES和DCB均可触发氧化应激标志物的初始升高，强调其对血管的急性影响。有趣的是，尽管没有统计学意义，DCB组在pci后1个月表现出更快速的氧化应激下降趋势。这些初步发现强调了DCBs促进血管更快恢复的潜力，值得进一步研究其长期临床优势。
Comparison of Oxidative Stress Effects Between Drug-Eluting Stents and Drug-Coated Balloons: Insights Into Vascular Response and Clinical Implications
Background
Percutaneous coronary intervention (PCI) has evolved with the development of drug-eluting stents (DES) and drug-coated balloons (DCB), both of which play a crucial role in reducing restenosis and major adverse cardiovascular events (MACE). Despite their benefits, the oxidative stress response triggered by these interventions and its implications for vascular healing remain unclear.
Aims
This study aims to compare the oxidative stress burden associated with DES and DCB by evaluating changes in plasma total peroxidase (TP) levels over time.
Methods
This observational, comparative study included 110 patients (60 DES and 50 DCB) who underwent PCI for stable coronary artery disease. TP levels were measured pre-procedure, 24 h postprocedure, and 1 month after PCI. Statistical comparisons were used to determine significant differences in oxidative stress between the two groups over time.
Results
Preoperative TP levels were comparable between the DES and DCB groups (431.00 ± 4.56 vs. 436.50 ± 4.14 µmol/L, p = 0.110). At 24 h post-PCI, TP levels increased significantly in both groups (DES: 449.50 ± 6.51 µmol/L, DCB: 442.50 ± 4.14 µmol/L), with a greater rise observed in the DES group, though not statistically significant (p = 0.42). At the 1-month follow-up, TP levels decreased significantly below baseline in both groups, with a more pronounced reduction in the DCB group (398.50 ± 4.14 vs. 406.50 ± 4.51 µmol/L, p = 0.11).
Conclusion
This study reveals that both DES and DCB procedures trigger an initial rise in oxidative stress markers, emphasizing their acute vascular impact. Intriguingly, although not statistically significant, the DCB group demonstrated a trend toward a more rapid decline in oxidative stress at 1 month post-PCI. These preliminary findings highlight the potential of DCBs to foster quicker vascular recovery, warranting further investigation into their long-term clinical advantages.
期刊介绍：
Catheterization and Cardiovascular Interventions is an international journal covering the broad field of cardiovascular diseases. Subject material includes basic and clinical information that is derived from or related to invasive and interventional coronary or peripheral vascular techniques. The journal focuses on material that will be of immediate practical value to physicians providing patient care in the clinical laboratory setting. To accomplish this, the journal publishes Preliminary Reports and Work In Progress articles that complement the traditional Original Studies, Case Reports, and Comprehensive Reviews. Perspective and insight concerning controversial subjects and evolving technologies are provided regularly through Editorial Commentaries furnished by members of the Editorial Board and other experts. Articles are subject to double-blind peer review and complete editorial evaluation prior to any decision regarding acceptability.
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