{"title":"参、螺旋藻对乙醇性大鼠胃炎模型保护作用的研究。","authors":"İdris Oruç, Zelal Karakoç, Filiz Akduman, Zeynep Oruç, Nazan Baksi, Muzaffer Aydin Ketani","doi":"10.1590/acb406725","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the protective effect of Caesalpinia sappan and spirulina against gastritis and determine changes in the expression of CD8, CD68, and major histocompatibility complex (MHC) molecules.</p><p><strong>Methods: </strong>Gastritis was induced in 24 female Wistar albino rats on the first day using ethanol. The treatment groups were given C. sappan (250 mg/kg) and spirulina (400 mg/kg) using oral gavage for five days. Blood and stomach tissue samples of the mice were analyzed.</p><p><strong>Results: </strong>Caesalpinia sappan and spirulina increased CD8 and CD68 expression and tumor necrosis factor-alpha levels thereby decreasing the severity of inflammation. It was found that they simultaneously decreased MHC I and MHC II expressing cells, increased superoxide dismutase levels, whereas malondialdehyde, and myeloperoxidase levels decreased in the treatment group.</p><p><strong>Conclusion: </strong>This study revealed that C. sappan and spirulina can protect gastric mucosa by reducing oxidative stress and inflammation.</p>","PeriodicalId":93850,"journal":{"name":"Acta cirurgica brasileira","volume":"40 ","pages":"e406725"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452209/pdf/","citationCount":"0","resultStr":"{\"title\":\"Investigation of the protective efficacy of Caesalpinia sappan and spirulina against ethanol-induced experimental rat gastritis model.\",\"authors\":\"İdris Oruç, Zelal Karakoç, Filiz Akduman, Zeynep Oruç, Nazan Baksi, Muzaffer Aydin Ketani\",\"doi\":\"10.1590/acb406725\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To evaluate the protective effect of Caesalpinia sappan and spirulina against gastritis and determine changes in the expression of CD8, CD68, and major histocompatibility complex (MHC) molecules.</p><p><strong>Methods: </strong>Gastritis was induced in 24 female Wistar albino rats on the first day using ethanol. The treatment groups were given C. sappan (250 mg/kg) and spirulina (400 mg/kg) using oral gavage for five days. Blood and stomach tissue samples of the mice were analyzed.</p><p><strong>Results: </strong>Caesalpinia sappan and spirulina increased CD8 and CD68 expression and tumor necrosis factor-alpha levels thereby decreasing the severity of inflammation. It was found that they simultaneously decreased MHC I and MHC II expressing cells, increased superoxide dismutase levels, whereas malondialdehyde, and myeloperoxidase levels decreased in the treatment group.</p><p><strong>Conclusion: </strong>This study revealed that C. sappan and spirulina can protect gastric mucosa by reducing oxidative stress and inflammation.</p>\",\"PeriodicalId\":93850,\"journal\":{\"name\":\"Acta cirurgica brasileira\",\"volume\":\"40 \",\"pages\":\"e406725\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452209/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta cirurgica brasileira\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1590/acb406725\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta cirurgica brasileira","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1590/acb406725","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Investigation of the protective efficacy of Caesalpinia sappan and spirulina against ethanol-induced experimental rat gastritis model.
Purpose: To evaluate the protective effect of Caesalpinia sappan and spirulina against gastritis and determine changes in the expression of CD8, CD68, and major histocompatibility complex (MHC) molecules.
Methods: Gastritis was induced in 24 female Wistar albino rats on the first day using ethanol. The treatment groups were given C. sappan (250 mg/kg) and spirulina (400 mg/kg) using oral gavage for five days. Blood and stomach tissue samples of the mice were analyzed.
Results: Caesalpinia sappan and spirulina increased CD8 and CD68 expression and tumor necrosis factor-alpha levels thereby decreasing the severity of inflammation. It was found that they simultaneously decreased MHC I and MHC II expressing cells, increased superoxide dismutase levels, whereas malondialdehyde, and myeloperoxidase levels decreased in the treatment group.
Conclusion: This study revealed that C. sappan and spirulina can protect gastric mucosa by reducing oxidative stress and inflammation.
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