Camila Pinho E Souza Coelho, Joana Rodrigues da Silva, Rafaella Cristhina Rego Marques, Jéssica Luiza Mendonça Albuquerque de Melo, Larisse Mendonça Alves, Carlos Daniel Correa de Oliveira Melo, Eduarda Carvalho Leite, Priscilla Fernandes, Rafael Lara Brasil, Pedro Chagas Pereira Neto, Fernanda de Paula E Silva Nunes, Solange Baraldi, Debora Heller, Maria do Carmo Machado Guimarães, Érica Negrini Lia, Naile Dame-Teixeira
{"title":"唾液流量和衰老：每年年龄下降的横断面估计。","authors":"Camila Pinho E Souza Coelho, Joana Rodrigues da Silva, Rafaella Cristhina Rego Marques, Jéssica Luiza Mendonça Albuquerque de Melo, Larisse Mendonça Alves, Carlos Daniel Correa de Oliveira Melo, Eduarda Carvalho Leite, Priscilla Fernandes, Rafael Lara Brasil, Pedro Chagas Pereira Neto, Fernanda de Paula E Silva Nunes, Solange Baraldi, Debora Heller, Maria do Carmo Machado Guimarães, Érica Negrini Lia, Naile Dame-Teixeira","doi":"10.1016/j.oooo.2025.08.008","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Although reduced salivary flow is often linked to aging, the extent of this decline across different age groups remains unclear. This study investigated the relationship between salivary flow and age, accounting for type 2 diabetes (T2D), polypharmacy, and fiber intake, aiming to estimate an annual rate of decline.</p><p><strong>Study design: </strong>Adults and elderly participants (mean age 54 ± 11 years) were recruited for this cross-sectional study. Resting salivary flow (RSF), stimulated salivary flow (SSF), pH, buffering capacity, viscoelasticity, medication intake and, T2D diagnosis were the main variables analyzed. Participants were classified as having hyposalivation if RSF < 0.1 mL/min or SSF < 0.7 mL/min. Associations were tested using unadjusted and adjusted robust linear regression (P < .05).</p><p><strong>Results: </strong>Sialometry was completed for 166 individuals. Hyposalivation was identified in 31% by RSF and 89% by SSF. Among adults under 60 years(n = 118), 28 (24%) had RSF hyposalivation and 99 (85%) had SSF hyposalivation. Older participants had significantly lower RSF and SSF. Salivary flow was estimated to decrease by 0.005 mL/min per year of age, independent of T2D and medication use.</p><p><strong>Conclusion: </strong>Salivary flow is associated with age, independent of T2D and medication use. Although the decline appears predictable (0.005ml/min/year), its clinical relevance warrants further investigation through longitudinal studies.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Salivary flow and aging: a cross-sectional estimate of the annual decline per year of age.\",\"authors\":\"Camila Pinho E Souza Coelho, Joana Rodrigues da Silva, Rafaella Cristhina Rego Marques, Jéssica Luiza Mendonça Albuquerque de Melo, Larisse Mendonça Alves, Carlos Daniel Correa de Oliveira Melo, Eduarda Carvalho Leite, Priscilla Fernandes, Rafael Lara Brasil, Pedro Chagas Pereira Neto, Fernanda de Paula E Silva Nunes, Solange Baraldi, Debora Heller, Maria do Carmo Machado Guimarães, Érica Negrini Lia, Naile Dame-Teixeira\",\"doi\":\"10.1016/j.oooo.2025.08.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Although reduced salivary flow is often linked to aging, the extent of this decline across different age groups remains unclear. This study investigated the relationship between salivary flow and age, accounting for type 2 diabetes (T2D), polypharmacy, and fiber intake, aiming to estimate an annual rate of decline.</p><p><strong>Study design: </strong>Adults and elderly participants (mean age 54 ± 11 years) were recruited for this cross-sectional study. Resting salivary flow (RSF), stimulated salivary flow (SSF), pH, buffering capacity, viscoelasticity, medication intake and, T2D diagnosis were the main variables analyzed. Participants were classified as having hyposalivation if RSF < 0.1 mL/min or SSF < 0.7 mL/min. Associations were tested using unadjusted and adjusted robust linear regression (P < .05).</p><p><strong>Results: </strong>Sialometry was completed for 166 individuals. Hyposalivation was identified in 31% by RSF and 89% by SSF. Among adults under 60 years(n = 118), 28 (24%) had RSF hyposalivation and 99 (85%) had SSF hyposalivation. Older participants had significantly lower RSF and SSF. Salivary flow was estimated to decrease by 0.005 mL/min per year of age, independent of T2D and medication use.</p><p><strong>Conclusion: </strong>Salivary flow is associated with age, independent of T2D and medication use. Although the decline appears predictable (0.005ml/min/year), its clinical relevance warrants further investigation through longitudinal studies.</p>\",\"PeriodicalId\":49010,\"journal\":{\"name\":\"Oral Surgery Oral Medicine Oral Pathology Oral Radiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-08-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oral Surgery Oral Medicine Oral Pathology Oral Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.oooo.2025.08.008\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.oooo.2025.08.008","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Salivary flow and aging: a cross-sectional estimate of the annual decline per year of age.
Objective: Although reduced salivary flow is often linked to aging, the extent of this decline across different age groups remains unclear. This study investigated the relationship between salivary flow and age, accounting for type 2 diabetes (T2D), polypharmacy, and fiber intake, aiming to estimate an annual rate of decline.
Study design: Adults and elderly participants (mean age 54 ± 11 years) were recruited for this cross-sectional study. Resting salivary flow (RSF), stimulated salivary flow (SSF), pH, buffering capacity, viscoelasticity, medication intake and, T2D diagnosis were the main variables analyzed. Participants were classified as having hyposalivation if RSF < 0.1 mL/min or SSF < 0.7 mL/min. Associations were tested using unadjusted and adjusted robust linear regression (P < .05).
Results: Sialometry was completed for 166 individuals. Hyposalivation was identified in 31% by RSF and 89% by SSF. Among adults under 60 years(n = 118), 28 (24%) had RSF hyposalivation and 99 (85%) had SSF hyposalivation. Older participants had significantly lower RSF and SSF. Salivary flow was estimated to decrease by 0.005 mL/min per year of age, independent of T2D and medication use.
Conclusion: Salivary flow is associated with age, independent of T2D and medication use. Although the decline appears predictable (0.005ml/min/year), its clinical relevance warrants further investigation through longitudinal studies.
期刊介绍：
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.
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