Paul Olowoyo, Osahon J Asowata, Onoja Akpa, Mary E Comeau, Christopher D Anderson, Jacob L McCauley, Joshua Akinyemi, Morenikeji Komolafe, Albert Akpalu, Oyedunni Arulogun, Fred Sarfo, Reginald Obiako, Godwin Osaigbovo, Adekunle Fakunle, Olufunmilola Macaulay, Olayinka Adebajo, Godwin Ogbole, Akinkunmi Paul Okekunle, Arti Singh, Innocent Chukwuonye, Oladotun Olalusi, Ayomide Owolabi, Atinuke Agunloye, Yaw Mensah, Carolyn Jenkins, Mayowa Ogunronbi, Osimhiarherhuo Adeleye, Ezinne Uvere, Kolawole Wahab, Philip Ibinaiye, Okechukwu Ogah, Lambert Appiah, Michael B Fawale, Samuel Diala, Hemant Tiwari, Rufus Akinyemi, Donna K Arnett, Carl D Langefeld, Bruce Ovbiagele, Daniel Woo, Mayowa Owolabi
{"title":"祖源和地理因素对非洲人和美洲人脑出血风险的影响","authors":"Paul Olowoyo, Osahon J Asowata, Onoja Akpa, Mary E Comeau, Christopher D Anderson, Jacob L McCauley, Joshua Akinyemi, Morenikeji Komolafe, Albert Akpalu, Oyedunni Arulogun, Fred Sarfo, Reginald Obiako, Godwin Osaigbovo, Adekunle Fakunle, Olufunmilola Macaulay, Olayinka Adebajo, Godwin Ogbole, Akinkunmi Paul Okekunle, Arti Singh, Innocent Chukwuonye, Oladotun Olalusi, Ayomide Owolabi, Atinuke Agunloye, Yaw Mensah, Carolyn Jenkins, Mayowa Ogunronbi, Osimhiarherhuo Adeleye, Ezinne Uvere, Kolawole Wahab, Philip Ibinaiye, Okechukwu Ogah, Lambert Appiah, Michael B Fawale, Samuel Diala, Hemant Tiwari, Rufus Akinyemi, Donna K Arnett, Carl D Langefeld, Bruce Ovbiagele, Daniel Woo, Mayowa Owolabi","doi":"10.1161/STROKEAHA.125.051911","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>We investigated whether risk factors for intracerebral hemorrhage (ICH) among indigenous Africans (IA) would vary in prevalence and effect compared with self-reported African, Hispanic, and White Americans by comparing data from 2 independent population-based case-control studies conducted in West Africa and the United States.</p><p><strong>Methods: </strong>We compared ICH risk factors common to the SIREN (Stroke Investigative Research and Educational Network: 1100 case-control pairs) and the ERICH (Ethnic/Racial Variation of Intracerebral Hemorrhage: 999 case-control pairs Black participants, 998 case-control pairs, Hispanic Americans, 1000 case-control pairs, White Americans) studies. Ethnicity/Race was self-reported. The effect measure of interest is the odds ratio (OR). To test for differences in the effects of the risk factors between the SIREN IA study population and each of the ERICH study populations, a test for heterogeneity was computed using the R program, metagen (version 4.9-6).</p><p><strong>Results: </strong>ICH occurred at a younger age among IA (54.3±13.4 years), Balck participants (58.0±12.7), and Hispanic Americans (58.9±14.3), compared with White Americans (69.1±13.9). The largest distinction was for hypertension, where IA exhibited a much larger risk of ICH than the American study population (OR, 67.02 [95% CI, 33.30-134.85]), Black population (OR, 3.71 [95% CI, 2.53-5.44]); Hispanic (OR, 3.55 [95% CI, 2.54-4.92]), and White population (OR, 2.69 [95% CI, 1.95-3.69]). Current alcohol use exhibited increased risk in IA (OR, 2.24 [95% CI, 1.36-3.67]), but not in Black participants (OR, 0.63 [95% CI, 0.46-0.86]), Hispanic (OR, 0.87 [95% CI, 0.65-1.17]), and White Americans (OR, 0.51 [95% CI, 0.38-0.69]).</p><p><strong>Conclusions: </strong>Identical or comparable risk factors do not consistently result in the same disease risk across different cultures and regions. Therefore, to improve our understanding of the genetic determinants and biological pathways driving ICH risk, it is crucial to study multiple populations, including IA, while accounting for the influence of environmental and social factors.</p>","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":""},"PeriodicalIF":8.9000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12514358/pdf/","citationCount":"0","resultStr":"{\"title\":\"Influence of Ancestral and Geographic Factors on Intracerebral Hemorrhage Risks Among Africans and Americans.\",\"authors\":\"Paul Olowoyo, Osahon J Asowata, Onoja Akpa, Mary E Comeau, Christopher D Anderson, Jacob L McCauley, Joshua Akinyemi, Morenikeji Komolafe, Albert Akpalu, Oyedunni Arulogun, Fred Sarfo, Reginald Obiako, Godwin Osaigbovo, Adekunle Fakunle, Olufunmilola Macaulay, Olayinka Adebajo, Godwin Ogbole, Akinkunmi Paul Okekunle, Arti Singh, Innocent Chukwuonye, Oladotun Olalusi, Ayomide Owolabi, Atinuke Agunloye, Yaw Mensah, Carolyn Jenkins, Mayowa Ogunronbi, Osimhiarherhuo Adeleye, Ezinne Uvere, Kolawole Wahab, Philip Ibinaiye, Okechukwu Ogah, Lambert Appiah, Michael B Fawale, Samuel Diala, Hemant Tiwari, Rufus Akinyemi, Donna K Arnett, Carl D Langefeld, Bruce Ovbiagele, Daniel Woo, Mayowa Owolabi\",\"doi\":\"10.1161/STROKEAHA.125.051911\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>We investigated whether risk factors for intracerebral hemorrhage (ICH) among indigenous Africans (IA) would vary in prevalence and effect compared with self-reported African, Hispanic, and White Americans by comparing data from 2 independent population-based case-control studies conducted in West Africa and the United States.</p><p><strong>Methods: </strong>We compared ICH risk factors common to the SIREN (Stroke Investigative Research and Educational Network: 1100 case-control pairs) and the ERICH (Ethnic/Racial Variation of Intracerebral Hemorrhage: 999 case-control pairs Black participants, 998 case-control pairs, Hispanic Americans, 1000 case-control pairs, White Americans) studies. Ethnicity/Race was self-reported. The effect measure of interest is the odds ratio (OR). To test for differences in the effects of the risk factors between the SIREN IA study population and each of the ERICH study populations, a test for heterogeneity was computed using the R program, metagen (version 4.9-6).</p><p><strong>Results: </strong>ICH occurred at a younger age among IA (54.3±13.4 years), Balck participants (58.0±12.7), and Hispanic Americans (58.9±14.3), compared with White Americans (69.1±13.9). The largest distinction was for hypertension, where IA exhibited a much larger risk of ICH than the American study population (OR, 67.02 [95% CI, 33.30-134.85]), Black population (OR, 3.71 [95% CI, 2.53-5.44]); Hispanic (OR, 3.55 [95% CI, 2.54-4.92]), and White population (OR, 2.69 [95% CI, 1.95-3.69]). Current alcohol use exhibited increased risk in IA (OR, 2.24 [95% CI, 1.36-3.67]), but not in Black participants (OR, 0.63 [95% CI, 0.46-0.86]), Hispanic (OR, 0.87 [95% CI, 0.65-1.17]), and White Americans (OR, 0.51 [95% CI, 0.38-0.69]).</p><p><strong>Conclusions: </strong>Identical or comparable risk factors do not consistently result in the same disease risk across different cultures and regions. Therefore, to improve our understanding of the genetic determinants and biological pathways driving ICH risk, it is crucial to study multiple populations, including IA, while accounting for the influence of environmental and social factors.</p>\",\"PeriodicalId\":21989,\"journal\":{\"name\":\"Stroke\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":8.9000,\"publicationDate\":\"2025-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12514358/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Stroke\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1161/STROKEAHA.125.051911\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Stroke","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1161/STROKEAHA.125.051911","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Influence of Ancestral and Geographic Factors on Intracerebral Hemorrhage Risks Among Africans and Americans.
Background: We investigated whether risk factors for intracerebral hemorrhage (ICH) among indigenous Africans (IA) would vary in prevalence and effect compared with self-reported African, Hispanic, and White Americans by comparing data from 2 independent population-based case-control studies conducted in West Africa and the United States.
Methods: We compared ICH risk factors common to the SIREN (Stroke Investigative Research and Educational Network: 1100 case-control pairs) and the ERICH (Ethnic/Racial Variation of Intracerebral Hemorrhage: 999 case-control pairs Black participants, 998 case-control pairs, Hispanic Americans, 1000 case-control pairs, White Americans) studies. Ethnicity/Race was self-reported. The effect measure of interest is the odds ratio (OR). To test for differences in the effects of the risk factors between the SIREN IA study population and each of the ERICH study populations, a test for heterogeneity was computed using the R program, metagen (version 4.9-6).
Results: ICH occurred at a younger age among IA (54.3±13.4 years), Balck participants (58.0±12.7), and Hispanic Americans (58.9±14.3), compared with White Americans (69.1±13.9). The largest distinction was for hypertension, where IA exhibited a much larger risk of ICH than the American study population (OR, 67.02 [95% CI, 33.30-134.85]), Black population (OR, 3.71 [95% CI, 2.53-5.44]); Hispanic (OR, 3.55 [95% CI, 2.54-4.92]), and White population (OR, 2.69 [95% CI, 1.95-3.69]). Current alcohol use exhibited increased risk in IA (OR, 2.24 [95% CI, 1.36-3.67]), but not in Black participants (OR, 0.63 [95% CI, 0.46-0.86]), Hispanic (OR, 0.87 [95% CI, 0.65-1.17]), and White Americans (OR, 0.51 [95% CI, 0.38-0.69]).
Conclusions: Identical or comparable risk factors do not consistently result in the same disease risk across different cultures and regions. Therefore, to improve our understanding of the genetic determinants and biological pathways driving ICH risk, it is crucial to study multiple populations, including IA, while accounting for the influence of environmental and social factors.
期刊介绍：
Stroke is a monthly publication that collates reports of clinical and basic investigation of any aspect of the cerebral circulation and its diseases. The publication covers a wide range of disciplines including anesthesiology, critical care medicine, epidemiology, internal medicine, neurology, neuro-ophthalmology, neuropathology, neuropsychology, neurosurgery, nuclear medicine, nursing, radiology, rehabilitation, speech pathology, vascular physiology, and vascular surgery.
The audience of Stroke includes neurologists, basic scientists, cardiologists, vascular surgeons, internists, interventionalists, neurosurgeons, nurses, and physiatrists.
Stroke is indexed in Biological Abstracts, BIOSIS, CAB Abstracts, Chemical Abstracts, CINAHL, Current Contents, Embase, MEDLINE, and Science Citation Index Expanded.
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