极早产儿早期液体状态与严重脑室内出血或死亡

IF 2.6 3区 医学 Q1 PEDIATRICS
Lucinda J Weaver, Samuel J Gentle, Arie Nakhmani, Fazlur Rahman, Namasivayam Ambalavanan, Vivek V Shukla, Christine Stoops, David Askenazi, Colm P Travers
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引用次数: 0

摘要

背景:产后早期液体平衡测量可能与产后第一周极早产儿严重脑室内出血(sIVH)和/或死亡有关。方法:一项单中心、回顾性队列研究,纳入2014-2021年积极治疗的出生体重≥400 g、22-27周的新生儿。纵向混合效应模型比较了出生后7天内有和没有sIVH或死亡的婴儿的每日体液平衡协变量,包括血清钠、体重变化百分比、总液体摄入量、尿量和体液平衡(每日体重-出生体重/出生体重× 100)。开发了多元回归和机器学习模型来预测sIVH和/或死亡。纳入模型的变量包括体液平衡、胎龄、出生体重、产前皮质激素、倍数和性别。结果:我们纳入932例婴儿,平均±SD胎龄为25w2d±11d,出生体重746±212 g,其中195例(20.9%)发生sIVH和/或死亡。结论:在极早产儿中,早期液体状态测量与sIVH和/或死亡风险相关。流体状态测量的加入提高了预测sIVH和/或死亡的模型的性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early fluid status and severe intraventricular hemorrhage or death in extremely preterm infants.

Background: Measures of early postnatal fluid balance may be associated with severe intraventricular hemorrhage (sIVH) and/or death in extremely preterm infants in the first postnatal week.

Methods: A single-center, retrospective cohort study including actively treated inborn infants weighing ≥ 400 g and 22-27 weeks' gestation from 2014-2021. Longitudinal mixed effect models compared daily fluid balance covariates including serum sodium, percent weight change, total fluid intake, urine output, and fluid balance (daily weight - birth weight /birth weight × 100) among infants with and without sIVH or death, during the first seven postnatal days. Multiple regression and machine learning models were developed to predict sIVH and/or death. Variables that were incorporated into the models included measures of fluid balance, gestational age, birth weight, antenatal corticosteroids, multiples, and sex.

Results: We included 932 infants with mean ± SD gestational age of 25w2d ± 11d and birth weight of 746 ± 212 g of whom 195 (20.9%) had sIVH and/or death. Lower percentage weight change (p < 0.001), higher total fluid intake (p = 0.007), higher sodium (p = 0.007), and positive early fluid balance (p < 0.001) were associated with sIVH and/or death even after adjustment for baseline characteristics. The area under the receiver-operating curve (AUC) for regression models predicting sIVH and/or death incorporating baseline characteristics improved after adding fluid balance measures from 0.75 to 0.80, while the AUC for machine learning models improved from 0.72 to 0.84.

Conclusions: In extremely preterm infants, early fluid status measures were associated with risk of sIVH and/or death. The addition of fluid status measures improves the performance of models predicting sIVH and/or death.

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来源期刊
Pediatric Nephrology
Pediatric Nephrology 医学-泌尿学与肾脏学
CiteScore
4.70
自引率
20.00%
发文量
465
审稿时长
1 months
期刊介绍: International Pediatric Nephrology Association Pediatric Nephrology publishes original clinical research related to acute and chronic diseases that affect renal function, blood pressure, and fluid and electrolyte disorders in children. Studies may involve medical, surgical, nutritional, physiologic, biochemical, genetic, pathologic or immunologic aspects of disease, imaging techniques or consequences of acute or chronic kidney disease. There are 12 issues per year that contain Editorial Commentaries, Reviews, Educational Reviews, Original Articles, Brief Reports, Rapid Communications, Clinical Quizzes, and Letters to the Editors.
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