先进的幽门螺杆菌根除:目前的治疗策略和靶向受体的基于脂质纳米载体的潜力。

IF 3.5 3区 医学 Q3 IMMUNOLOGY
Mohamed Sharaf , Tehsin Ullah Khan , Chen-Guang Liu
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引用次数: 0

摘要

幽门螺杆菌(h.p ylori)是一种革兰氏阴性的嗜气微细菌,呈螺旋状。幽门螺杆菌感染仍然是最困难的挑战之一,导致慢性胃炎和消化性溃疡,增加因胃癌引起的死亡率,全球暴露率超过90%。迫切需要新的治疗策略来提高现代医学的现有进展。该脂质纳米载体具有药物包封性好、胃内滞留时间长、药物释放时间长、靶向幽门螺杆菌部位感染准确、多策略等优点。本文就幽门螺杆菌感染的细菌发病机制、毒力机制以及目前治疗幽门螺杆菌感染的不同疗效作一综述。此外,本文还综述了通过各种生物材料和自然过程制备的新型载药脂质微纳米递送系统如何通过影响胃维持特性和排泄率来对抗幽门螺杆菌感染,从而有助于完善治疗方法。此外,基于脂质的纳米载体的组合研究已经证明了对幽门螺杆菌感染的有效性,具有细胞毒性低,副作用小,抗菌潜力强的优点。这一综述将对利用脂质纳米递送系统对抗感染性病原体有潜在的贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Advance Helicobacter pylori eradication: Current therapeutic strategies and the potential of lipid-based nanocarriers for targeting receptors

Advance Helicobacter pylori eradication: Current therapeutic strategies and the potential of lipid-based nanocarriers for targeting receptors
Helicobacter pylori (H. pylori) is a Gram-negative bacteria microaerophilic, and spiral-shaped. H. pylori infection remains one of the most difficult challenges, resulting in chronic gastritis and peptic ulcers, increasing the mortality rate due to stomach cancer, exposed to more than 90 % worldwide. New treatment strategies are urgently needed to improve current advances in modern medicine. The lipid-based nanocarrier gained the advantages of drug encapsulation and high retention time in the stomach with the drug release rate for long periods and targeting H. pylori site infection accurately, with more than one strategy. This review article discusses bacterial pathogenesis, virulence mechanism of bacterial infection, and current different therapeutic effectiveness of fighting H. pylori infections. Moreover, this review provides an overview of how to use the novel designs of drugs-loaded lipid micro and nano delivery systems prepared through various biomaterials and natural processes to combat H. pylori infection through impact gastro-maintenance properties, discharge rates, which contributes to the perfection of therapeutic approaches. Moreover, combinatory studies of lipid-based nanocarrier have proven efficiency against H. pylori infection, with an advantage of lower cytotoxicity, minimal side effects, and stronger antibacterial potential. This review will have potential contribution in combating infectious pathogens using lipid-based nano delivery systems.
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来源期刊
Microbial pathogenesis
Microbial pathogenesis 医学-免疫学
CiteScore
7.40
自引率
2.60%
发文量
472
审稿时长
56 days
期刊介绍: Microbial Pathogenesis publishes original contributions and reviews about the molecular and cellular mechanisms of infectious diseases. It covers microbiology, host-pathogen interaction and immunology related to infectious agents, including bacteria, fungi, viruses and protozoa. It also accepts papers in the field of clinical microbiology, with the exception of case reports. Research Areas Include: -Pathogenesis -Virulence factors -Host susceptibility or resistance -Immune mechanisms -Identification, cloning and sequencing of relevant genes -Genetic studies -Viruses, prokaryotic organisms and protozoa -Microbiota -Systems biology related to infectious diseases -Targets for vaccine design (pre-clinical studies)
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