Viet Q Dinh, Malinda Hansen, K Austin Davis, Lindsey Peralez, Caroline A Rickards
{"title":"急性心脑血管血流对颈部高频、低振幅振动的反应。","authors":"Viet Q Dinh, Malinda Hansen, K Austin Davis, Lindsey Peralez, Caroline A Rickards","doi":"10.1152/japplphysiol.00328.2025","DOIUrl":null,"url":null,"abstract":"<p><p>Local muscle vibration (LMV) is a potential therapeutic approach to treat symptoms related to stroke by improving muscle function and blood flow. In this study, we assessed the acute cardiovascular and cerebral blood flow responses to LMV when applied to the anterior neck muscles in young and healthy participants. We hypothesized that LMV would elicit minimal acute cardiovascular responses. Ten human participants (5 male, 5 female) underwent LMV on both sides of their neck for 5-min each. Arterial pressure, middle cerebral artery blood velocity (MCAv), and common carotid artery (CCA) blood flow were measured continuously. There was no effect of LMV on <b>mean arterial pressure</b> (RIGHT, Baseline: 96.9±4.9 mmHg vs. LMV: 97.8±5.7 mmHg vs. Recovery: 98.2±4.6 mmHg, P=0.25; LEFT, Baseline: 96.0±7.8 mmHg vs. LMV: 97.0±7.7 mmHg vs. Recovery: 97.9±7.5 mmHg; P=0.23) or <b>MCAv</b> (RIGHT, Baseline: 61.4±10.5 cm/s vs. LMV: 62.0±10.7 cm/s vs. Recovery: 59.3±9.7 cm/s; P=0.15; LEFT, Baseline: 59.9±10.2 cm/s vs. LMV: 60.6±10.8 cm/s vs. Recovery: 58.4±10.2 cm/s; P=0.20). <b>CCA diameter</b> increased slightly with LMV on both sides of the neck (RIGHT, Baseline: 6.2±0.6 mm vs. LMV: 6.3±0.7 mm, P=0.03; LEFT, Baseline: 6.4±0.5 mm vs. LMV: 6.5±0.5 mm, P=0.03). However, this did not affect <b>CCA blood flow</b> (RIGHT, Baseline: 330.7±68.5 ml/min vs. LMV: 324.7±57.6 ml/min, P=0.59; LEFT, Baseline: 358.1±67.5 vs. LMV: 344.2±78.3 ml/min, P=0.30). These data provide evidence that a single acute session of LMV does not affect key cardiovascular parameters in young and healthy participants.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Acute cardiovascular and cerebral blood flow responses to high frequency, low amplitude vibration on the neck.\",\"authors\":\"Viet Q Dinh, Malinda Hansen, K Austin Davis, Lindsey Peralez, Caroline A Rickards\",\"doi\":\"10.1152/japplphysiol.00328.2025\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Local muscle vibration (LMV) is a potential therapeutic approach to treat symptoms related to stroke by improving muscle function and blood flow. In this study, we assessed the acute cardiovascular and cerebral blood flow responses to LMV when applied to the anterior neck muscles in young and healthy participants. We hypothesized that LMV would elicit minimal acute cardiovascular responses. Ten human participants (5 male, 5 female) underwent LMV on both sides of their neck for 5-min each. Arterial pressure, middle cerebral artery blood velocity (MCAv), and common carotid artery (CCA) blood flow were measured continuously. There was no effect of LMV on <b>mean arterial pressure</b> (RIGHT, Baseline: 96.9±4.9 mmHg vs. LMV: 97.8±5.7 mmHg vs. Recovery: 98.2±4.6 mmHg, P=0.25; LEFT, Baseline: 96.0±7.8 mmHg vs. LMV: 97.0±7.7 mmHg vs. Recovery: 97.9±7.5 mmHg; P=0.23) or <b>MCAv</b> (RIGHT, Baseline: 61.4±10.5 cm/s vs. LMV: 62.0±10.7 cm/s vs. Recovery: 59.3±9.7 cm/s; P=0.15; LEFT, Baseline: 59.9±10.2 cm/s vs. LMV: 60.6±10.8 cm/s vs. Recovery: 58.4±10.2 cm/s; P=0.20). <b>CCA diameter</b> increased slightly with LMV on both sides of the neck (RIGHT, Baseline: 6.2±0.6 mm vs. LMV: 6.3±0.7 mm, P=0.03; LEFT, Baseline: 6.4±0.5 mm vs. LMV: 6.5±0.5 mm, P=0.03). However, this did not affect <b>CCA blood flow</b> (RIGHT, Baseline: 330.7±68.5 ml/min vs. LMV: 324.7±57.6 ml/min, P=0.59; LEFT, Baseline: 358.1±67.5 vs. LMV: 344.2±78.3 ml/min, P=0.30). These data provide evidence that a single acute session of LMV does not affect key cardiovascular parameters in young and healthy participants.</p>\",\"PeriodicalId\":15160,\"journal\":{\"name\":\"Journal of applied physiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of applied physiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1152/japplphysiol.00328.2025\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of applied physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1152/japplphysiol.00328.2025","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
局部肌肉振动(LMV)是一种通过改善肌肉功能和血液流动来治疗中风相关症状的潜在治疗方法。在这项研究中,我们评估了年轻和健康参与者对LMV应用于前颈部肌肉时的急性心血管和脑血流反应。我们假设LMV会引起最小的急性心血管反应。10名参与者(5名男性,5名女性)在颈部两侧进行LMV,各5分钟。连续测量动脉压、大脑中动脉血流速度(MCAv)、颈总动脉血流(CCA)。LMV对平均动脉压(右,基线:96.9±4.9 mmHg vs LMV: 97.8±5.7 mmHg vs恢复:98.2±4.6 mmHg, P=0.25;左,基线:96.0±7.8 mmHg vs LMV: 97.0±7.7 mmHg vs恢复:97.9±7.5 mmHg, P=0.23)或MCAv(右,基线:61.4±10.5 cm/s vs LMV: 62.0±10.7 cm/s vs恢复:59.3±9.7 cm/s, P=0.15;左,基线:59.9±10.2 cm/s vs LMV: 60.6±10.8 cm/s vs恢复:58.4±10.2 cm/s, P=0.20)没有影响。颈部两侧CCA直径随LMV的增加而轻微增加(右侧,基线:6.2±0.6 mm vs LMV: 6.3±0.7 mm, P=0.03;左侧,基线:6.4±0.5 mm vs LMV: 6.5±0.5 mm, P=0.03)。然而,这并不影响CCA血流量(右,基线:330.7±68.5 ml/min vs LMV: 324.7±57.6 ml/min, P=0.59;左,基线:358.1±67.5 vs LMV: 344.2±78.3 ml/min, P=0.30)。这些数据提供了证据,证明单次急性期LMV不影响年轻和健康参与者的关键心血管参数。
Acute cardiovascular and cerebral blood flow responses to high frequency, low amplitude vibration on the neck.
Local muscle vibration (LMV) is a potential therapeutic approach to treat symptoms related to stroke by improving muscle function and blood flow. In this study, we assessed the acute cardiovascular and cerebral blood flow responses to LMV when applied to the anterior neck muscles in young and healthy participants. We hypothesized that LMV would elicit minimal acute cardiovascular responses. Ten human participants (5 male, 5 female) underwent LMV on both sides of their neck for 5-min each. Arterial pressure, middle cerebral artery blood velocity (MCAv), and common carotid artery (CCA) blood flow were measured continuously. There was no effect of LMV on mean arterial pressure (RIGHT, Baseline: 96.9±4.9 mmHg vs. LMV: 97.8±5.7 mmHg vs. Recovery: 98.2±4.6 mmHg, P=0.25; LEFT, Baseline: 96.0±7.8 mmHg vs. LMV: 97.0±7.7 mmHg vs. Recovery: 97.9±7.5 mmHg; P=0.23) or MCAv (RIGHT, Baseline: 61.4±10.5 cm/s vs. LMV: 62.0±10.7 cm/s vs. Recovery: 59.3±9.7 cm/s; P=0.15; LEFT, Baseline: 59.9±10.2 cm/s vs. LMV: 60.6±10.8 cm/s vs. Recovery: 58.4±10.2 cm/s; P=0.20). CCA diameter increased slightly with LMV on both sides of the neck (RIGHT, Baseline: 6.2±0.6 mm vs. LMV: 6.3±0.7 mm, P=0.03; LEFT, Baseline: 6.4±0.5 mm vs. LMV: 6.5±0.5 mm, P=0.03). However, this did not affect CCA blood flow (RIGHT, Baseline: 330.7±68.5 ml/min vs. LMV: 324.7±57.6 ml/min, P=0.59; LEFT, Baseline: 358.1±67.5 vs. LMV: 344.2±78.3 ml/min, P=0.30). These data provide evidence that a single acute session of LMV does not affect key cardiovascular parameters in young and healthy participants.
期刊介绍:
The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.