Green Innovations in Analytical Methodologies for Metoprolol Determination: A Review on Sustainable Approaches in Pharmaceutical Analysis.

Metoprolol, a widely prescribed beta-blocker used in the treatment of cardiovascular diseases, necessitates precise and reliable determination in pharmaceutical formulations and biological samples. Traditional analytical methods, while effective, often involve hazardous chemicals, extensive energy consumption, and the use of large volumes of solvents, raising environmental concerns. This review focuses on the green innovations in analytical methodologies for metoprolol determination. It examines alternative techniques that minimize environmental impact, including eco-friendly solvents, reagentless detection methods, and energy-efficient approaches. Key green technologies such as chromatography, spectrometry, and electrochemical techniques are discussed, with an emphasis on their potential to replace or enhance traditional methods. It introduces Analytical GREEnness Metric Approach, Green Analytical Procedure Index, Blue Applicability Grade Index, Carbon Footprint Reduction Index and Click analytical chemistry tools as critical frameworks for assessing the sustainability and efficiency of green analytical approaches. These tools provide a standardized approach to evaluate various green methods based on factors such as waste reduction, solvent use, energy consumption, and overall environmental footprint. Additionally, the review examines how these frameworks can guide the development of new green technologies in metoprolol analysis. The study concludes with recommendations for future research, emphasizing the importance of integrating green chemistry principles into pharmaceutical analysis and quality control while minimizing environmental impacts.