David Nygren, Felix Andersson, Ebrima Barrow, Sheikh Omar Bittaye, Haddy Bah, Fatou Banja, Kumba Suun Mboob, Lamin Fatajo, Marisel Gomez Blanco, Emmanuel Olabode, Alieu Jallow, Abdoulie Badjan, Paul Rahden
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Bloodstream Infections and Antimicrobial Resistance in The Gambia: Continuous Surveillance from a Tertiary Care Center.
Antimicrobial resistance (AMR) poses a major threat to global health, with limited surveillance data available from western sub-Saharan Africa. After reports of high rates of methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase (ESBL) in bloodstream infections at The Gambia's sole tertiary hospital, we present follow-up data after enhancements in microbiology capacity. This study included 1,010 patients with blood cultures taken at Edward Francis Small Teaching Hospital between September 2023 and August 2024. The positivity rate remained high (31%), particularly among neonates and critically ill patients. Staphylococcus aureus was the most frequently isolated pathogen (49%, n = 155/314), with MRSA identified in 22% (n = 34/152) of tested isolates. Among Enterobacterales, ESBL production remained high (87%, n = 84/97), and carbapenem resistance was detected in 15% (n = 6/39) of tested isolates. Our findings highlight the need for a robust and sustained AMR surveillance system to inform targeted interventions aimed at reducing the emergence and spread of multidrug-resistant pathogens.
期刊介绍：
The American Journal of Tropical Medicine and Hygiene, established in 1921, is published monthly by the American Society of Tropical Medicine and Hygiene. It is among the top-ranked tropical medicine journals in the world publishing original scientific articles and the latest science covering new research with an emphasis on population, clinical and laboratory science and the application of technology in the fields of tropical medicine, parasitology, immunology, infectious diseases, epidemiology, basic and molecular biology, virology and international medicine.
The Journal publishes unsolicited peer-reviewed manuscripts, review articles, short reports, images in Clinical Tropical Medicine, case studies, reports on the efficacy of new drugs and methods of treatment, prevention and control methodologies,new testing methods and equipment, book reports and Letters to the Editor. Topics range from applied epidemiology in such relevant areas as AIDS to the molecular biology of vaccine development.
The Journal is of interest to epidemiologists, parasitologists, virologists, clinicians, entomologists and public health officials who are concerned with health issues of the tropics, developing nations and emerging infectious diseases. Major granting institutions including philanthropic and governmental institutions active in the public health field, and medical and scientific libraries throughout the world purchase the Journal.
Two or more supplements to the Journal on topics of special interest are published annually. These supplements represent comprehensive and multidisciplinary discussions of issues of concern to tropical disease specialists and health issues of developing countries
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