{"title":"铁代谢研究：卵巢子宫内膜异位症合并不孕症患者铁代谢特点","authors":"Limian Huang, Weiling Qin, Tongye Su, Haiyan Pang, Delong Xie, Jiejie Liao, Xiao Qin","doi":"10.1111/jog.70058","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>This study investigates iron metabolism characteristics in patients with ovarian endometriosis (EMs) and infertility.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A case–control study was conducted involving 76 infertility patients treated at Baise People's Hospital from December 2023 to December 2024. Among them, 36 patients with ovarian EMs and infertility were included in the case group, whereas 40 infertile women without EMs constituted the control group. The indices of iron metabolism, including serum iron (SI), transferrin (TRF), soluble transferrin receptor (sTfR), unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC), and transferrin saturation (TS), were measured and compared between the two groups. Furthermore, the association between iron metabolism levels and the development and progression of EMs was systematically analyzed.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The SI level was significantly higher in the study group than in the control group (<i>p</i> < 0.01). Levels of TRF, UIBC, and TIBC were significantly lower in the study group compared to the control group (<i>p</i> < 0.001). No significant differences were observed in sTfR or TS between the two groups (<i>p</i> > 0.05). Receiver operating characteristic curve analysis demonstrated that the combined assessment of SI, TRF, UIBC, and TIBC provided statistically significant diagnostic accuracy for differentiating between the two groups, with corresponding <i>p</i> values less than 0.01.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Abnormal iron metabolism is present in patients with EMs and infertility. Excessive iron accumulation may exacerbate disease progression and influence reproductive prognosis. Modulating iron metabolism could potentially serve as a novel strategy to improve the condition of EMs and pregnancy outcomes.</p>\n </section>\n </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 9","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70058","citationCount":"0","resultStr":"{\"title\":\"Iron metabolism study: The characteristics of iron metabolism in patients with ovarian endometriosis complicated with infertility\",\"authors\":\"Limian Huang, Weiling Qin, Tongye Su, Haiyan Pang, Delong Xie, Jiejie Liao, Xiao Qin\",\"doi\":\"10.1111/jog.70058\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>This study investigates iron metabolism characteristics in patients with ovarian endometriosis (EMs) and infertility.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A case–control study was conducted involving 76 infertility patients treated at Baise People's Hospital from December 2023 to December 2024. Among them, 36 patients with ovarian EMs and infertility were included in the case group, whereas 40 infertile women without EMs constituted the control group. The indices of iron metabolism, including serum iron (SI), transferrin (TRF), soluble transferrin receptor (sTfR), unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC), and transferrin saturation (TS), were measured and compared between the two groups. Furthermore, the association between iron metabolism levels and the development and progression of EMs was systematically analyzed.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The SI level was significantly higher in the study group than in the control group (<i>p</i> < 0.01). Levels of TRF, UIBC, and TIBC were significantly lower in the study group compared to the control group (<i>p</i> < 0.001). No significant differences were observed in sTfR or TS between the two groups (<i>p</i> > 0.05). Receiver operating characteristic curve analysis demonstrated that the combined assessment of SI, TRF, UIBC, and TIBC provided statistically significant diagnostic accuracy for differentiating between the two groups, with corresponding <i>p</i> values less than 0.01.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Abnormal iron metabolism is present in patients with EMs and infertility. Excessive iron accumulation may exacerbate disease progression and influence reproductive prognosis. Modulating iron metabolism could potentially serve as a novel strategy to improve the condition of EMs and pregnancy outcomes.</p>\\n </section>\\n </div>\",\"PeriodicalId\":16593,\"journal\":{\"name\":\"Journal of Obstetrics and Gynaecology Research\",\"volume\":\"51 9\",\"pages\":\"\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.70058\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Obstetrics and Gynaecology Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.70058\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Obstetrics and Gynaecology Research","FirstCategoryId":"3","ListUrlMain":"https://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.70058","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Iron metabolism study: The characteristics of iron metabolism in patients with ovarian endometriosis complicated with infertility
Objectives
This study investigates iron metabolism characteristics in patients with ovarian endometriosis (EMs) and infertility.
Methods
A case–control study was conducted involving 76 infertility patients treated at Baise People's Hospital from December 2023 to December 2024. Among them, 36 patients with ovarian EMs and infertility were included in the case group, whereas 40 infertile women without EMs constituted the control group. The indices of iron metabolism, including serum iron (SI), transferrin (TRF), soluble transferrin receptor (sTfR), unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC), and transferrin saturation (TS), were measured and compared between the two groups. Furthermore, the association between iron metabolism levels and the development and progression of EMs was systematically analyzed.
Results
The SI level was significantly higher in the study group than in the control group (p < 0.01). Levels of TRF, UIBC, and TIBC were significantly lower in the study group compared to the control group (p < 0.001). No significant differences were observed in sTfR or TS between the two groups (p > 0.05). Receiver operating characteristic curve analysis demonstrated that the combined assessment of SI, TRF, UIBC, and TIBC provided statistically significant diagnostic accuracy for differentiating between the two groups, with corresponding p values less than 0.01.
Conclusion
Abnormal iron metabolism is present in patients with EMs and infertility. Excessive iron accumulation may exacerbate disease progression and influence reproductive prognosis. Modulating iron metabolism could potentially serve as a novel strategy to improve the condition of EMs and pregnancy outcomes.
期刊介绍：
The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology.
The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.
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