{"title":"利用水动力在聚合物中空微纤维内表面自主播种微粒","authors":"Saurabh S. Aykar, Nicole N. Hashemi","doi":"10.1002/admi.202500345","DOIUrl":null,"url":null,"abstract":"<p>Lateral displacement of microparticles suspended in a viscoelastic fluid flowing through a microfluidic channel occurs due to an imbalance in the first (N1) and second (N2) normal stress differences. Here, the lateral displacement of fluorescent microparticles suspended in a polyethylene glycol (PEG) solution in a two-phase flow with aqueous sodium alginate, flowing through a unique microfluidic device that manufactures microparticles seeded alginate-based hollow microfibers is studied. Parameters such as concentration of the aqueous sodium alginate and flow rate ratios are optimized to enhance microparticle seeding density and minimize their loss to the collection bath. 4% w/v aqueous sodium alginate is observed to confine the suspended microparticles within the hollow region of microfibers as compared to 2% w/v. Moreover, the higher flow rate ratio of the core fluid, 250 µL min<sup>−1</sup> results in about 192% increase in the microparticle seeding density as compared to its lower flow rate of 100 µL min<sup>−1</sup>. The shear thinning index (<i>m</i>) is measured to be 0.91 for 2% w/v and 0.75 for 4% w/v sodium alginate solutions. These results provide insights into understanding microparticle displacement within a viscoelastic polymer solution flowing through a microfluidic channel, motivating further studies in biofabrication, and cellular seeding and sorting.</p>","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"12 18","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/admi.202500345","citationCount":"0","resultStr":"{\"title\":\"Autonomous Seeding of Microparticles on the Inner Surface of Polymer Hollow Microfibers Using Hydrodynamic Forces\",\"authors\":\"Saurabh S. Aykar, Nicole N. Hashemi\",\"doi\":\"10.1002/admi.202500345\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Lateral displacement of microparticles suspended in a viscoelastic fluid flowing through a microfluidic channel occurs due to an imbalance in the first (N1) and second (N2) normal stress differences. Here, the lateral displacement of fluorescent microparticles suspended in a polyethylene glycol (PEG) solution in a two-phase flow with aqueous sodium alginate, flowing through a unique microfluidic device that manufactures microparticles seeded alginate-based hollow microfibers is studied. Parameters such as concentration of the aqueous sodium alginate and flow rate ratios are optimized to enhance microparticle seeding density and minimize their loss to the collection bath. 4% w/v aqueous sodium alginate is observed to confine the suspended microparticles within the hollow region of microfibers as compared to 2% w/v. Moreover, the higher flow rate ratio of the core fluid, 250 µL min<sup>−1</sup> results in about 192% increase in the microparticle seeding density as compared to its lower flow rate of 100 µL min<sup>−1</sup>. The shear thinning index (<i>m</i>) is measured to be 0.91 for 2% w/v and 0.75 for 4% w/v sodium alginate solutions. These results provide insights into understanding microparticle displacement within a viscoelastic polymer solution flowing through a microfluidic channel, motivating further studies in biofabrication, and cellular seeding and sorting.</p>\",\"PeriodicalId\":115,\"journal\":{\"name\":\"Advanced Materials Interfaces\",\"volume\":\"12 18\",\"pages\":\"\"},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2025-08-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/admi.202500345\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Materials Interfaces\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://advanced.onlinelibrary.wiley.com/doi/10.1002/admi.202500345\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Materials Interfaces","FirstCategoryId":"88","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/admi.202500345","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
悬浮在粘弹性流体中的微颗粒通过微流体通道时,由于第一(N1)和第二(N2)正应力差的不平衡而发生侧向位移。在这里,荧光微颗粒悬浮在聚乙二醇(PEG)溶液中,与海藻酸钠水溶液在两相流中流过一种独特的微流体装置,该装置制造微颗粒种子海藻酸盐基中空微纤维,研究了荧光微颗粒的侧向位移。优化了海藻酸钠水溶液浓度和流速比等参数,以提高微粒的播种密度,并最大限度地减少它们在收集浴中的损失。与2% w/v的海藻酸钠相比,4% w/v的海藻酸钠水溶液能将悬浮微粒限制在微纤维的中空区域内。此外,当芯液的流速比为250µL min - 1时,微粒的播种密度比为100µL min - 1时增加了约192%。在2% w/v的海藻酸钠溶液中,剪切减薄指数(m)为0.91,在4% w/v的海藻酸钠溶液中为0.75。这些结果为理解通过微流体通道的粘弹性聚合物溶液中的微粒位移提供了见解,推动了生物制造、细胞播种和分选的进一步研究。
Autonomous Seeding of Microparticles on the Inner Surface of Polymer Hollow Microfibers Using Hydrodynamic Forces
Lateral displacement of microparticles suspended in a viscoelastic fluid flowing through a microfluidic channel occurs due to an imbalance in the first (N1) and second (N2) normal stress differences. Here, the lateral displacement of fluorescent microparticles suspended in a polyethylene glycol (PEG) solution in a two-phase flow with aqueous sodium alginate, flowing through a unique microfluidic device that manufactures microparticles seeded alginate-based hollow microfibers is studied. Parameters such as concentration of the aqueous sodium alginate and flow rate ratios are optimized to enhance microparticle seeding density and minimize their loss to the collection bath. 4% w/v aqueous sodium alginate is observed to confine the suspended microparticles within the hollow region of microfibers as compared to 2% w/v. Moreover, the higher flow rate ratio of the core fluid, 250 µL min−1 results in about 192% increase in the microparticle seeding density as compared to its lower flow rate of 100 µL min−1. The shear thinning index (m) is measured to be 0.91 for 2% w/v and 0.75 for 4% w/v sodium alginate solutions. These results provide insights into understanding microparticle displacement within a viscoelastic polymer solution flowing through a microfluidic channel, motivating further studies in biofabrication, and cellular seeding and sorting.
期刊介绍:
Advanced Materials Interfaces publishes top-level research on interface technologies and effects. Considering any interface formed between solids, liquids, and gases, the journal ensures an interdisciplinary blend of physics, chemistry, materials science, and life sciences. Advanced Materials Interfaces was launched in 2014 and received an Impact Factor of 4.834 in 2018.
The scope of Advanced Materials Interfaces is dedicated to interfaces and surfaces that play an essential role in virtually all materials and devices. Physics, chemistry, materials science and life sciences blend to encourage new, cross-pollinating ideas, which will drive forward our understanding of the processes at the interface.
Advanced Materials Interfaces covers all topics in interface-related research:
Oil / water separation,
Applications of nanostructured materials,
2D materials and heterostructures,
Surfaces and interfaces in organic electronic devices,
Catalysis and membranes,
Self-assembly and nanopatterned surfaces,
Composite and coating materials,
Biointerfaces for technical and medical applications.
Advanced Materials Interfaces provides a forum for topics on surface and interface science with a wide choice of formats: Reviews, Full Papers, and Communications, as well as Progress Reports and Research News.