金催化环化和重排合成功能化环醚

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-09-24 DOI:10.1002/adsc.70012

Akiko Fujii, Kwihwan Kobayashi, Tomoki Hyodo, Tsuyoshi Yamada, Takashi Ikawa, Hironao Sajiki

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引用次数: 0

摘要

环醚是天然产物和药物中普遍存在的结构基序，其高效合成引起了有机合成领域的广泛关注。提出了一种由环醚保护的邻炔芳基甲醇衍生物经金催化的分子内环化和重排实现环醚功能化的合成方法。金催化的6端环化反应产生了多种功能化环醚。此外，这种转化使得从含有O -糖苷的炔基化合物合成C -糖苷衍生物成为可能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of Functionalized Cyclic Ethers via Gold‐Catalyzed Cyclization and Rearrangement

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Synthesis of Functionalized Cyclic Ethers via Gold‐Catalyzed Cyclization and Rearrangement

Cyclic ethers are prevalent structural motifs in natural products and pharmaceuticals, and their efficient synthesis has attracted significant attention in organic synthesis. A synthetic approach for the functionalization of cyclic ethers from ortho‐alkynylarylmethanol derivatives protected by cyclic ethers via gold‐catalyzed intramolecular cyclization and rearrangement is developed. The gold‐catalyzed 6‐endo‐dig cyclization yielded various functionalized cyclic ethers. Furthermore, this transformation enabled the synthesis of C‐glycoside derivatives from alkynyl compounds bearing O‐glycosides.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.