{"title":"希望渺茫？在一项前瞻性纵向研究中，情感气质预测不孕症治疗期间药物治疗的依从性。","authors":"Georgina Szabo, Krisztina Soltesz, Judit Szigeti F, Szabolcs Varbiro, Miklos Sipos, Xenia Gonda","doi":"10.1080/19585969.2025.2563529","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Research suggests that affective temperaments influence adherence to pharmacotherapy; however, this has not been investigated in infertility treatment. Our prospective longitudinal study assessed the impact of affective temperaments on medication adherence during infertility treatments.</p><p><strong>Methods: </strong>179 women presenting at an Assisted Reproduction Centre completed the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego (TEMPS-A) questionnaire before treatment, and the Morisky Medication Adherence Scale (MMAS) six months later. Univariate linear regression assessed whether affective temperaments predict medication adherence; multivariate and interaction models examined the influence of sociodemographic and medical variables on this relationship, and potential moderating effects of age and education.</p><p><strong>Results: </strong>Higher cyclothymic, depressive, irritable, and anxious affective temperament scores predicted significantly poorer adherence to pharmacotherapeutic recommendations (<i>β</i> = -0.122, <i>p</i> < 0.001, <i>β</i> = -0.178, <i>p</i> < 0.001, <i>β</i> = -0.114, <i>p</i> = 0.002, <i>β</i> = -0.071, <i>p</i> = 0.08; respectively). These results remained significant in multivariate models including sociodemographic and medical factors, which did not influence adherence. Increasing age intensified the negative impact of anxious temperament on medication adherence (<i>β</i> = -0.015, <i>p</i> = 0.024).</p><p><strong>Conclusions: </strong>Affective temperaments impact adherence to pharmacotherapeutic recommendations among women experiencing infertility, possibly influencing treatment outcomes. Screening for affective temperaments can identify patients at risk of medication non-adherence. Applying patient-tailored psychological interventions to aid adherence could increase the chances of successful pregnancies.</p>","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"276-284"},"PeriodicalIF":8.9000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12459188/pdf/","citationCount":"0","resultStr":"{\"title\":\"A long shot? Affective temperaments predict adherence to pharmacotherapy during infertility treatment in a prospective longitudinal study.\",\"authors\":\"Georgina Szabo, Krisztina Soltesz, Judit Szigeti F, Szabolcs Varbiro, Miklos Sipos, Xenia Gonda\",\"doi\":\"10.1080/19585969.2025.2563529\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Research suggests that affective temperaments influence adherence to pharmacotherapy; however, this has not been investigated in infertility treatment. Our prospective longitudinal study assessed the impact of affective temperaments on medication adherence during infertility treatments.</p><p><strong>Methods: </strong>179 women presenting at an Assisted Reproduction Centre completed the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego (TEMPS-A) questionnaire before treatment, and the Morisky Medication Adherence Scale (MMAS) six months later. Univariate linear regression assessed whether affective temperaments predict medication adherence; multivariate and interaction models examined the influence of sociodemographic and medical variables on this relationship, and potential moderating effects of age and education.</p><p><strong>Results: </strong>Higher cyclothymic, depressive, irritable, and anxious affective temperament scores predicted significantly poorer adherence to pharmacotherapeutic recommendations (<i>β</i> = -0.122, <i>p</i> < 0.001, <i>β</i> = -0.178, <i>p</i> < 0.001, <i>β</i> = -0.114, <i>p</i> = 0.002, <i>β</i> = -0.071, <i>p</i> = 0.08; respectively). These results remained significant in multivariate models including sociodemographic and medical factors, which did not influence adherence. Increasing age intensified the negative impact of anxious temperament on medication adherence (<i>β</i> = -0.015, <i>p</i> = 0.024).</p><p><strong>Conclusions: </strong>Affective temperaments impact adherence to pharmacotherapeutic recommendations among women experiencing infertility, possibly influencing treatment outcomes. Screening for affective temperaments can identify patients at risk of medication non-adherence. Applying patient-tailored psychological interventions to aid adherence could increase the chances of successful pregnancies.</p>\",\"PeriodicalId\":54343,\"journal\":{\"name\":\"Dialogues in Clinical Neuroscience\",\"volume\":\"27 1\",\"pages\":\"276-284\"},\"PeriodicalIF\":8.9000,\"publicationDate\":\"2025-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12459188/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dialogues in Clinical Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/19585969.2025.2563529\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/23 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dialogues in Clinical Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/19585969.2025.2563529","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/23 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
研究表明，情感气质影响药物治疗的依从性；然而，这在不孕症治疗中尚未得到研究。我们的前瞻性纵向研究评估了情感气质对不孕症治疗期间药物依从性的影响。方法：179名在辅助生殖中心就诊的妇女在治疗前完成孟菲斯、比萨、巴黎和圣地亚哥气质评价问卷（TEMPS-A）， 6个月后完成莫里斯基药物依从性量表（MMAS）。单变量线性回归评估情感气质是否预测药物依从性；多变量和相互作用模型检验了社会人口学和医学变量对这种关系的影响，以及年龄和教育的潜在调节作用。结果：较高的环胸腺、抑郁、易怒和焦虑情感气质评分预示着较差的药物治疗依从性（分别为β = -0.122, p β = -0.178, p β = -0.114, p = 0.002, β = -0.071, p = 0.08）。这些结果在包括社会人口统计学和医学因素在内的多变量模型中仍然显著，这些因素不影响依从性。随着年龄的增长，焦虑气质对药物依从性的负向影响加剧（β = -0.015, p = 0.024）。结论：情感气质影响不孕妇女对药物治疗建议的依从性，可能影响治疗结果。对情感气质的筛查可以识别出有药物不依从风险的患者。应用适合患者的心理干预来帮助坚持，可以增加成功怀孕的机会。
A long shot? Affective temperaments predict adherence to pharmacotherapy during infertility treatment in a prospective longitudinal study.
Introduction: Research suggests that affective temperaments influence adherence to pharmacotherapy; however, this has not been investigated in infertility treatment. Our prospective longitudinal study assessed the impact of affective temperaments on medication adherence during infertility treatments.
Methods: 179 women presenting at an Assisted Reproduction Centre completed the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego (TEMPS-A) questionnaire before treatment, and the Morisky Medication Adherence Scale (MMAS) six months later. Univariate linear regression assessed whether affective temperaments predict medication adherence; multivariate and interaction models examined the influence of sociodemographic and medical variables on this relationship, and potential moderating effects of age and education.
Results: Higher cyclothymic, depressive, irritable, and anxious affective temperament scores predicted significantly poorer adherence to pharmacotherapeutic recommendations (β = -0.122, p < 0.001, β = -0.178, p < 0.001, β = -0.114, p = 0.002, β = -0.071, p = 0.08; respectively). These results remained significant in multivariate models including sociodemographic and medical factors, which did not influence adherence. Increasing age intensified the negative impact of anxious temperament on medication adherence (β = -0.015, p = 0.024).
Conclusions: Affective temperaments impact adherence to pharmacotherapeutic recommendations among women experiencing infertility, possibly influencing treatment outcomes. Screening for affective temperaments can identify patients at risk of medication non-adherence. Applying patient-tailored psychological interventions to aid adherence could increase the chances of successful pregnancies.
期刊介绍：
Dialogues in Clinical Neuroscience (DCNS) endeavors to bridge the gap between clinical neuropsychiatry and the neurosciences by offering state-of-the-art information and original insights into pertinent clinical, biological, and therapeutic aspects. As an open access journal, DCNS ensures accessibility to its content for all interested parties. Each issue is curated to include expert reviews, original articles, and brief reports, carefully selected to offer a comprehensive understanding of the evolving landscape in clinical neuroscience. Join us in advancing knowledge and fostering dialogue in this dynamic field.
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