卵巢癌细胞死亡研究的最新发现及潜在应用

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Anh-Dao Ngo, Tung-Duong Luu, Hai-Quang Pham, Ha-Le Dang, Dinh-Toi Chu
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引用次数: 0

摘要

卵巢癌是女性最主要的妇科健康问题之一,它不仅对女性而且对全人类都造成了巨大的疾病负担。这种疾病的巨大负担来自于它经常在晚期被发现,目前的治疗方法,如化疗或放疗不是很有效,导致5年生存率很低。因此,迫切需要发现针对卵巢肿瘤形成和转移过程的新治疗方法。其中,调节细胞死亡过程正成为消除包括卵巢癌在内的癌症的一种有希望的治疗方法。许多科学家一直在研究和临床测试控制细胞死亡过程的方法和药物分子,包括凋亡,坏死,铁下垂,铜下垂或焦下垂,以破坏肿瘤。在这项工作中,我们展示了细胞死亡在卵巢癌细胞控制中的重要性的概述。根据目前对细胞死亡机制的了解,已经研究了靶向药物和方法来调节卵巢肿瘤治疗中细胞死亡过程的激活/抑制。正因为如此,人们探索了新的希望,以帮助提高癌症诊断和治疗的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current findings and potential applications of cell death research in ovarian cancer.

One of the top gynecological health problems for women is ovarian cancer (OC) and it causes a huge disease burden not only for women but for all of humanity. The disease's immense burden comes from it often detected at advanced stages, current treatments such as chemotherapy or radiotherapy are not very effective, leading to a low 5-year survival rate. Therefore, discovering new therapeutic approaches that target the processes contributing to ovarian tumor formation and metastasis is urgently needed. Among them, regulating cell death processes is emerging as a promising therapy for eliminating cancer including ovarian cancer. Many scientists have been researching and clinically testing methods and drug molecules to control cell death processes consisting of apoptosis, necroptosis, ferroptosis, cuproptosis, or pyroptosis to destroy tumors. In this work, we displayed an overview about the importance of cell death in the control of ovarian carcinoma cells. According to the current knowledge of the mechanisms of cell death, targeted drugs and approaches have been studied to modulate the activation/inhibition of this process in the treatment of ovarian tumor. Thanks to that, new hopes are explored to help improve the effectiveness of cancer diagnosis and treatment.

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来源期刊
CiteScore
5.00
自引率
0.00%
发文量
110
审稿时长
4-8 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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