Jonathan Laatsch, Friederike S David, Frederike Stein, Carlo Maj, Andreas J Forstner, Simon Maier, Swantje Matthies, Esther Sobanski, Barbara Alm, Ludger Tebartz van Elst, Axel Krug, Alexandra Philipsen
{"title":"沟深度和遗传易感性影响成人注意力缺陷/多动障碍的初始治疗反应。","authors":"Jonathan Laatsch, Friederike S David, Frederike Stein, Carlo Maj, Andreas J Forstner, Simon Maier, Swantje Matthies, Esther Sobanski, Barbara Alm, Ludger Tebartz van Elst, Axel Krug, Alexandra Philipsen","doi":"10.1016/j.bpsc.2025.09.012","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>As neurobiological markers gain prominence in guiding personalised treatments, sulcal depth (SD) remains an underexplored yet pivotal factor in neural processing and therapeutic efficacy. While genetic influences shape cortical architecture, their role in modulating the relationship between SD and treatment outcomes remain unclear. This study investigates whether pre-treatment SD predicts symptom alleviation in adults with Attention-Deficit/Hyperactivity Disorder (ADHD) and explores moderating effects of genetic susceptibility for ADHD and cross-disorder influences.</p><p><strong>Methods: </strong>Using structural neuroimaging data from the Comparison of Methylphenidate and Psychotherapy in Adult ADHD Study, we examined associations between SD and treatment response following a 12-week intervention involving either group psychotherapy or clinical management with methylphenidate or placebo. Pre-treatment SD was derived from 119 T1-weighted anatomical scans and analysed using linear regression models to assess its predictive value for post-treatment symptom severity. Subsequently, we explored the moderating role of polygenic scores for ADHD and cross-disorder susceptibility. Structural analyses were performed using the threshold-free cluster enhancement approach in the Computational Anatomy Toolbox, with moderation analyses conducted in SPSS (30.0.0).</p><p><strong>Results: </strong>Results revealed that SD in parietal, temporal, and occipital regions significantly predicted symptom alleviation, linking deeper sulci with greater treatment efficacy. Moreover, genetic predisposition for ADHD and cross-disorder traits influenced these relationships, highlighting an interaction between cortical structure and genetic susceptibility in determining treatment outcomes.</p><p><strong>Conclusion: </strong>These findings highlight SD as a promising neurobiological marker of ADHD treatment response and emphasize the importance of integrating neurobiological- and genetic factors into predictive models of therapeutic efficacy in psychiatry.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sulcal Depth and Genetic Susceptibility influence initial Treatment Response in Adults with Attention-Deficit/Hyperactivity Disorder.\",\"authors\":\"Jonathan Laatsch, Friederike S David, Frederike Stein, Carlo Maj, Andreas J Forstner, Simon Maier, Swantje Matthies, Esther Sobanski, Barbara Alm, Ludger Tebartz van Elst, Axel Krug, Alexandra Philipsen\",\"doi\":\"10.1016/j.bpsc.2025.09.012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>As neurobiological markers gain prominence in guiding personalised treatments, sulcal depth (SD) remains an underexplored yet pivotal factor in neural processing and therapeutic efficacy. While genetic influences shape cortical architecture, their role in modulating the relationship between SD and treatment outcomes remain unclear. This study investigates whether pre-treatment SD predicts symptom alleviation in adults with Attention-Deficit/Hyperactivity Disorder (ADHD) and explores moderating effects of genetic susceptibility for ADHD and cross-disorder influences.</p><p><strong>Methods: </strong>Using structural neuroimaging data from the Comparison of Methylphenidate and Psychotherapy in Adult ADHD Study, we examined associations between SD and treatment response following a 12-week intervention involving either group psychotherapy or clinical management with methylphenidate or placebo. Pre-treatment SD was derived from 119 T1-weighted anatomical scans and analysed using linear regression models to assess its predictive value for post-treatment symptom severity. Subsequently, we explored the moderating role of polygenic scores for ADHD and cross-disorder susceptibility. Structural analyses were performed using the threshold-free cluster enhancement approach in the Computational Anatomy Toolbox, with moderation analyses conducted in SPSS (30.0.0).</p><p><strong>Results: </strong>Results revealed that SD in parietal, temporal, and occipital regions significantly predicted symptom alleviation, linking deeper sulci with greater treatment efficacy. Moreover, genetic predisposition for ADHD and cross-disorder traits influenced these relationships, highlighting an interaction between cortical structure and genetic susceptibility in determining treatment outcomes.</p><p><strong>Conclusion: </strong>These findings highlight SD as a promising neurobiological marker of ADHD treatment response and emphasize the importance of integrating neurobiological- and genetic factors into predictive models of therapeutic efficacy in psychiatry.</p>\",\"PeriodicalId\":93900,\"journal\":{\"name\":\"Biological psychiatry. Cognitive neuroscience and neuroimaging\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biological psychiatry. 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Sulcal Depth and Genetic Susceptibility influence initial Treatment Response in Adults with Attention-Deficit/Hyperactivity Disorder.
Background: As neurobiological markers gain prominence in guiding personalised treatments, sulcal depth (SD) remains an underexplored yet pivotal factor in neural processing and therapeutic efficacy. While genetic influences shape cortical architecture, their role in modulating the relationship between SD and treatment outcomes remain unclear. This study investigates whether pre-treatment SD predicts symptom alleviation in adults with Attention-Deficit/Hyperactivity Disorder (ADHD) and explores moderating effects of genetic susceptibility for ADHD and cross-disorder influences.
Methods: Using structural neuroimaging data from the Comparison of Methylphenidate and Psychotherapy in Adult ADHD Study, we examined associations between SD and treatment response following a 12-week intervention involving either group psychotherapy or clinical management with methylphenidate or placebo. Pre-treatment SD was derived from 119 T1-weighted anatomical scans and analysed using linear regression models to assess its predictive value for post-treatment symptom severity. Subsequently, we explored the moderating role of polygenic scores for ADHD and cross-disorder susceptibility. Structural analyses were performed using the threshold-free cluster enhancement approach in the Computational Anatomy Toolbox, with moderation analyses conducted in SPSS (30.0.0).
Results: Results revealed that SD in parietal, temporal, and occipital regions significantly predicted symptom alleviation, linking deeper sulci with greater treatment efficacy. Moreover, genetic predisposition for ADHD and cross-disorder traits influenced these relationships, highlighting an interaction between cortical structure and genetic susceptibility in determining treatment outcomes.
Conclusion: These findings highlight SD as a promising neurobiological marker of ADHD treatment response and emphasize the importance of integrating neurobiological- and genetic factors into predictive models of therapeutic efficacy in psychiatry.
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