Johanna Muhigana, Rwego Antoine Gasasira, Hélène Nicolis
{"title":"预防幼儿HIV垂直传播对神经发育的影响？系统回顾。","authors":"Johanna Muhigana, Rwego Antoine Gasasira, Hélène Nicolis","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Children infected with the Human Immunodeficiency Virus (HIV) exhibit the lowest neurodevelopmental scores. Mother-to-child-transmission prevention include perinatally and early antiretroviral therapy (ART) although long-term effects of in utero exposure to ART on neurodevelopment remain unclear. It was difficult to determine whether these reported neurodevelopmental scores were a direct result of HIV.</p><p><strong>Methods: </strong>A systematic search was conducted to identify the environmental and neurobiological factors associated with HIV infection and their impact on neurodevelopment. It was carried out across four electronic databases: Scopus, PubMed, ProQuest and Cochrane Database of Systematic Reviews. We selected 15 articles published between 2012 and 2024.</p><p><strong>Results: </strong>Regarding ART, 4 articles reported a positive effect of ART regardless of the age of initiation and duration. We couldn't identify caregiver distress as a risk factor.</p><p><strong>Conclusions: </strong>Further research should include large cohort studies assessing long term consequences of ART exposition on children's neurodevelopment and impact of caregiver distress on child neurodevelopmental outcomes.</p>","PeriodicalId":20760,"journal":{"name":"Psychiatria Danubina","volume":"37 Suppl 1","pages":"135-139"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"POSSIBLE PREVENTION OF NEURODEVELOPMENTAL CONSEQUENCES OF VERTICAL HIV TRANSMISSION IN EARLY CHILDHOOD? A SYSTEMATIC REVIEW.\",\"authors\":\"Johanna Muhigana, Rwego Antoine Gasasira, Hélène Nicolis\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Children infected with the Human Immunodeficiency Virus (HIV) exhibit the lowest neurodevelopmental scores. Mother-to-child-transmission prevention include perinatally and early antiretroviral therapy (ART) although long-term effects of in utero exposure to ART on neurodevelopment remain unclear. It was difficult to determine whether these reported neurodevelopmental scores were a direct result of HIV.</p><p><strong>Methods: </strong>A systematic search was conducted to identify the environmental and neurobiological factors associated with HIV infection and their impact on neurodevelopment. It was carried out across four electronic databases: Scopus, PubMed, ProQuest and Cochrane Database of Systematic Reviews. We selected 15 articles published between 2012 and 2024.</p><p><strong>Results: </strong>Regarding ART, 4 articles reported a positive effect of ART regardless of the age of initiation and duration. We couldn't identify caregiver distress as a risk factor.</p><p><strong>Conclusions: </strong>Further research should include large cohort studies assessing long term consequences of ART exposition on children's neurodevelopment and impact of caregiver distress on child neurodevelopmental outcomes.</p>\",\"PeriodicalId\":20760,\"journal\":{\"name\":\"Psychiatria Danubina\",\"volume\":\"37 Suppl 1\",\"pages\":\"135-139\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychiatria Danubina\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychiatria Danubina","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
POSSIBLE PREVENTION OF NEURODEVELOPMENTAL CONSEQUENCES OF VERTICAL HIV TRANSMISSION IN EARLY CHILDHOOD? A SYSTEMATIC REVIEW.
Background: Children infected with the Human Immunodeficiency Virus (HIV) exhibit the lowest neurodevelopmental scores. Mother-to-child-transmission prevention include perinatally and early antiretroviral therapy (ART) although long-term effects of in utero exposure to ART on neurodevelopment remain unclear. It was difficult to determine whether these reported neurodevelopmental scores were a direct result of HIV.
Methods: A systematic search was conducted to identify the environmental and neurobiological factors associated with HIV infection and their impact on neurodevelopment. It was carried out across four electronic databases: Scopus, PubMed, ProQuest and Cochrane Database of Systematic Reviews. We selected 15 articles published between 2012 and 2024.
Results: Regarding ART, 4 articles reported a positive effect of ART regardless of the age of initiation and duration. We couldn't identify caregiver distress as a risk factor.
Conclusions: Further research should include large cohort studies assessing long term consequences of ART exposition on children's neurodevelopment and impact of caregiver distress on child neurodevelopmental outcomes.
期刊介绍：
Psychiatria Danubina is a peer-reviewed open access journal of the Psychiatric Danubian Association, aimed to publish original scientific contributions in psychiatry, psychological medicine and related science (neurosciences, biological, psychological, and social sciences as well as philosophy of science and medical ethics, history, organization and economics of mental health services).
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