基于β-环糊精结构的谷胱甘肽响应超分子胶束：结合光动力疗法和化疗治疗癌症。

IF 4.3 3区医学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Pharmaceutical Research Pub Date : 2025-09-01 Epub Date: 2025-09-22 DOI:10.1007/s11095-025-03926-z

Chao Zhou, Shuqing Zhang, Yamin Li, Yi Yao, Tian Si, Bo Yang

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引用次数: 0

摘要

目的：抗癌药水溶性差、利用率低、毒副作用大，严重影响肿瘤治疗。本研究旨在设计和开发一种多疗法智能给药系统，解决这些问题，通过化疗和光动力治疗相结合，提高癌症治疗的疗效。方法：合成以β-环糊精和卟啉衍生物为基础的两亲性超分子TPPC6-SS-CD。该化合物在水溶液中自组装成胶束，显示谷胱甘肽响应特性。结果：谷胱甘肽成功地裂解胶束，释放依托泊苷和卟啉。这种释放导致化疗和光动力联合治疗，诱导肿瘤细胞死亡。在425 nm照射下，负载依托泊苷的胶束对肿瘤细胞生长的抑制作用优于游离依托泊苷和卟啉。结论：本研究提出了一种用于化疗和光动力联合给药的新型超分子纳米载体。这一发现证明了该系统在肿瘤治疗方面的潜力，为生物、化学和光动力行业的药物传递载体的发展提供了有价值的见解。

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Glutathione-Responsive Supramolecular Micelles Based on β-Cyclodextrin Construction: Combining Photodynamic Therapy and Chemotherapy for Cancer Treatment.

Purpose: Anticancer drugs often suffer from poor water solubility, low utilization rates, and high side effects, which significantly impact cancer treatment. This study aims to design and develop a multi-therapy intelligent drug delivery system that can address these issues and improve the therapeutic efficacy of cancer treatment by combining chemotherapy and photodynamic therapy.

Methods: An amphiphilic supramolecular, TPPC6-SS-CD, based on β-cyclodextrin and porphyrin derivatives, was synthesized. The compound self-assembles into micelles in aqueous solution, demonstrating glutathione-responsive properties.

Results: The micelles were successfully cleaved by glutathione, enabling the release of etoposide and porphyrin. This release resulted in combined chemotherapy and photodynamic therapy, inducing tumor cell death. Under 425 nm irradiation, the micelles loaded with etoposide showed better tumor cell growth inhibition compared to the free etoposide and porphyrin.

Conclusion: This study presents a new type of supramolecular nanocarriers designed for the combined delivery of chemotherapy and photodynamic therapy. The findings demonstrate the potential of this system for tumor treatment, offering valuable insights for the development of drug delivery vectors in biological, chemical, and photodynamic industries.

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来源期刊

Pharmaceutical Research 医学-化学综合

CiteScore

6.60

自引率

5.40%

发文量

276

审稿时长

3.4 months

期刊介绍： Pharmaceutical Research, an official journal of the American Association of Pharmaceutical Scientists, is committed to publishing novel research that is mechanism-based, hypothesis-driven and addresses significant issues in drug discovery, development and regulation. Current areas of interest include, but are not limited to: -(pre)formulation engineering and processing- computational biopharmaceutics- drug delivery and targeting- molecular biopharmaceutics and drug disposition (including cellular and molecular pharmacology)- pharmacokinetics, pharmacodynamics and pharmacogenetics. Research may involve nonclinical and clinical studies, and utilize both in vitro and in vivo approaches. Studies on small drug molecules, pharmaceutical solid materials (including biomaterials, polymers and nanoparticles) biotechnology products (including genes, peptides, proteins and vaccines), and genetically engineered cells are welcome.