Anna Fogelström, Charlotte Skoglund, Eva Hagel, Tomas Wester, Anna Löf Granström, Carmen Mesas-Burgos
{"title":"先天性腹壁缺损儿童的神经发育障碍：一项基于全国人群的研究。","authors":"Anna Fogelström, Charlotte Skoglund, Eva Hagel, Tomas Wester, Anna Löf Granström, Carmen Mesas-Burgos","doi":"10.1007/s00383-025-06201-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>One in 4000 Swedish children is born with abdominal wall defect (AWD). Little is known about their neurodevelopmental trajectory and long-term morbidity. The aim was to determine the risk of neurodevelopmental disorders in children born with omphalocele or gastroschisis.</p><p><strong>Methods: </strong>This was a population-based national cohort study including children born with omphalocele or gastroschisis in Sweden 1997-2016. Individuals with chromosomal abnormality were excluded. Ten age and sex-matched unexposed individuals were randomly selected for every AWD case. Main outcomes were autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). Data were collected from the national health registers.</p><p><strong>Results: </strong>During the study period, 496 children were born with AWD and included in the exposed cohorts. The unexposed cohorts consisted of 4943 children. Neurodevelopmental diagnoses were found in 11 (6.1%) children with omphalocele and 15 (4.8%) children with gastroschisis compared to 63 (3.5%) and 113 (3.6%) in the unexposed cohorts (p = 0.096 and p = 0.275). Children with omphalocele had higher risk of ASD (HR = 3.51, 95% CI 1.59-7.78) than unexposed peers (p = 0.02). There was no significant difference in ADHD incidence.</p><p><strong>Conclusions: </strong>Children with AWD may have similar risk of ADHD as age- and sex-matched peers. While the omphalocele cohort had a higher incidence of ASD, the overall incidence remained relatively low.</p><p><strong>Level of evidence: </strong>II.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"303"},"PeriodicalIF":1.6000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454545/pdf/","citationCount":"0","resultStr":"{\"title\":\"Neurodevelopmental disorders in children with congenital abdominal wall defects: a national population-based study.\",\"authors\":\"Anna Fogelström, Charlotte Skoglund, Eva Hagel, Tomas Wester, Anna Löf Granström, Carmen Mesas-Burgos\",\"doi\":\"10.1007/s00383-025-06201-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>One in 4000 Swedish children is born with abdominal wall defect (AWD). Little is known about their neurodevelopmental trajectory and long-term morbidity. The aim was to determine the risk of neurodevelopmental disorders in children born with omphalocele or gastroschisis.</p><p><strong>Methods: </strong>This was a population-based national cohort study including children born with omphalocele or gastroschisis in Sweden 1997-2016. Individuals with chromosomal abnormality were excluded. Ten age and sex-matched unexposed individuals were randomly selected for every AWD case. Main outcomes were autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). Data were collected from the national health registers.</p><p><strong>Results: </strong>During the study period, 496 children were born with AWD and included in the exposed cohorts. The unexposed cohorts consisted of 4943 children. Neurodevelopmental diagnoses were found in 11 (6.1%) children with omphalocele and 15 (4.8%) children with gastroschisis compared to 63 (3.5%) and 113 (3.6%) in the unexposed cohorts (p = 0.096 and p = 0.275). Children with omphalocele had higher risk of ASD (HR = 3.51, 95% CI 1.59-7.78) than unexposed peers (p = 0.02). There was no significant difference in ADHD incidence.</p><p><strong>Conclusions: </strong>Children with AWD may have similar risk of ADHD as age- and sex-matched peers. While the omphalocele cohort had a higher incidence of ASD, the overall incidence remained relatively low.</p><p><strong>Level of evidence: </strong>II.</p>\",\"PeriodicalId\":19832,\"journal\":{\"name\":\"Pediatric Surgery International\",\"volume\":\"41 1\",\"pages\":\"303\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-09-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454545/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Surgery International\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00383-025-06201-9\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Surgery International","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00383-025-06201-9","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
Neurodevelopmental disorders in children with congenital abdominal wall defects: a national population-based study.
Purpose: One in 4000 Swedish children is born with abdominal wall defect (AWD). Little is known about their neurodevelopmental trajectory and long-term morbidity. The aim was to determine the risk of neurodevelopmental disorders in children born with omphalocele or gastroschisis.
Methods: This was a population-based national cohort study including children born with omphalocele or gastroschisis in Sweden 1997-2016. Individuals with chromosomal abnormality were excluded. Ten age and sex-matched unexposed individuals were randomly selected for every AWD case. Main outcomes were autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). Data were collected from the national health registers.
Results: During the study period, 496 children were born with AWD and included in the exposed cohorts. The unexposed cohorts consisted of 4943 children. Neurodevelopmental diagnoses were found in 11 (6.1%) children with omphalocele and 15 (4.8%) children with gastroschisis compared to 63 (3.5%) and 113 (3.6%) in the unexposed cohorts (p = 0.096 and p = 0.275). Children with omphalocele had higher risk of ASD (HR = 3.51, 95% CI 1.59-7.78) than unexposed peers (p = 0.02). There was no significant difference in ADHD incidence.
Conclusions: Children with AWD may have similar risk of ADHD as age- and sex-matched peers. While the omphalocele cohort had a higher incidence of ASD, the overall incidence remained relatively low.
期刊介绍：
Pediatric Surgery International is a journal devoted to the publication of new and important information from the entire spectrum of pediatric surgery. The major purpose of the journal is to promote postgraduate training and further education in the surgery of infants and children.
The contents will include articles in clinical and experimental surgery, as well as related fields. One section of each issue is devoted to a special topic, with invited contributions from recognized authorities. Other sections will include:
-Review articles-
Original articles-
Technical innovations-
Letters to the editor
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