估算儿童肾移植受者肾小球滤过率的不同公式的比较。

IF 2.6 3区 医学 Q1 PEDIATRICS
Paphawadee Sukboonthong, Julaporn Pooliam, Maturin Jantongsree, Achra Sumboonnanonda, Anirut Pattaragarn, Suroj Supavekin, Nuntawan Piyaphanee, Kraisoon Lomjansook, Yarnarin Thunsiribuddhichai, Intraparch Tinnabut, Nuttiporn Khueankong, Thanaporn Chaiyapak
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引用次数: 0

摘要

背景:准确的肾小球滤过率评估(eGFR)对管理儿童肾移植受者至关重要。考虑到接受成人供体肾脏的儿科患者的生理状况,确定最合适的血浆肌酐(PCr)配方——儿童或成人特异性——至关重要。方法:本横断面研究包括接受成人供体肾脏的儿童肾移植受者(年龄1-18岁)。我们通过类内相关系数(ICCs)、一致性相关系数(CCCs)、总偏差指数(TDI)、P30绩效指标(P30)、Bland-Altman图和接受者工作特征(ROC)分析,将各种儿童和成人基于pcr的GFR方程与CKiD 2012联合PCr-CystC (PCr-CystC)方程的一致性阈值进行比较。CKiD under 25 (U25) PCr-CystC与参考CKiD 2012方程的相关性也进行了评价。结果:从23例受者(平均年龄= 14.2±3.4岁)和供者(平均年龄= 31.7±10.0岁)中采集标本120份。在参考条件下,Schwartz-Lyon方程表现最佳(ICC = 0.913, CCC = 0.911, TDI = 14.0 mL/min/1.73 m2, P30 = 99.2%)。U25 (ICC = 0.922, CCC = 0.882, P30 = 93.3%)、全年龄谱(FAS)-身高(ICC = 0.897, CCC = 0.877, P30 = 96.7%)和床边施瓦茨方程(ICC = 0.850, CCC = 0.819, P30 = 89.2%)的表现相当。Bland-Altman图显示schwarz - lyon、U25和FAS-height的比例偏差(p = 2), bed Schwartz的最佳一致性阈值为2,超过该阈值后,每个方程的偏差都增加了。亚组分析也显示10-18岁的患者表现更好。U25 PCr-CystC方程与文献吻合良好(ICC = 0.993, CCC = 0.990, P30 = 100%)。结论:Schwartz-Lyon方程在儿童肾移植受者中表现出最高的参考pcr方程,特别是当eGFR为2时和10-18岁的患者。U25 PCr-CystC方程与参考文献的总体一致性最好,在CystC测量可行的情况下应优先使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of different equations for estimating the glomerular filtration rate in pediatric kidney transplant recipients.

Background: Accurate glomerular filtration rate estimation (eGFR) is essential for managing pediatric kidney transplant recipients. Given the physiology of pediatric patients receiving adult-donor kidneys, identifying the most appropriate plasma creatinine (PCr)-based formula-pediatric or adult-specific-is crucial.

Methods: This cross-sectional study included pediatric kidney transplant recipients (age 1-18 years) who received adult-donor kidneys. We compared agreement thresholds of various pediatric and adult PCr-based GFR equations with CKiD 2012 combined PCr‒cystatin C (PCr-CystC) equation via intraclass correlation coefficients (ICCs), concordance correlation coefficients (CCCs), total deviation index (TDI), P30 performance metric (P30), Bland-Altman plots, and receiver-operating characteristic (ROC) analysis. Correlation between CKiD under 25 (U25) PCr-CystC and reference CKiD 2012 equation was also evaluated.

Results: One hundred twenty samples were collected from 23 recipients (mean age = 14.2 ± 3.4 years) and donors (mean age = 31.7 ± 10.0 years). Schwartz-Lyon equation demonstrated the highest performance with the reference (ICC = 0.913, CCC = 0.911, TDI = 14.0 mL/min/1.73 m2, P30 = 99.2%). U25 (ICC = 0.922, CCC = 0.882, P30 = 93.3%), full age spectrum (FAS)-height (ICC = 0.897, CCC = 0.877, P30 = 96.7%), and Bedside Schwartz equations (ICC = 0.850, CCC = 0.819, P30 = 89.2%) showed comparable performance. Bland-Altman plots revealed proportional bias (p < 0.05), leading to ROC analysis, which identified eGFR < 70 mL/min/1.73 m2 for Schwartz-Lyon, U25, and FAS-height, and < 60 mL/min/1.73 m2 for Bedside Schwartz as optimal agreement thresholds, beyond which each equation showed increased bias. Subgroup analyses also showed better performance in patients aged 10-18 years. Additionally, U25 PCr-CystC equation showed excellent agreement with the reference (ICC = 0.993, CCC = 0.990, P30 = 100%).

Conclusions: Schwartz-Lyon equation demonstrated the highest performance among PCr-based equations with the reference in pediatric kidney transplant recipients, particularly when eGFR was < 70 mL/min/1.73 m2 and in patients aged 10-18 years. U25 PCr-CystC equation showed best overall agreement with the reference and should be preferred where CystC measurement is feasible.

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来源期刊
Pediatric Nephrology
Pediatric Nephrology 医学-泌尿学与肾脏学
CiteScore
4.70
自引率
20.00%
发文量
465
审稿时长
1 months
期刊介绍: International Pediatric Nephrology Association Pediatric Nephrology publishes original clinical research related to acute and chronic diseases that affect renal function, blood pressure, and fluid and electrolyte disorders in children. Studies may involve medical, surgical, nutritional, physiologic, biochemical, genetic, pathologic or immunologic aspects of disease, imaging techniques or consequences of acute or chronic kidney disease. There are 12 issues per year that contain Editorial Commentaries, Reviews, Educational Reviews, Original Articles, Brief Reports, Rapid Communications, Clinical Quizzes, and Letters to the Editors.
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