修复后的法洛四联症的4D血流mri衍生的肺反流分数的可靠性:测量位置和肺动脉几何形状的影响。

IF 3.5 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Hirozumi Mori, Michinobu Nagao, Tomohito Kogure, Seiji Asagai, Kei Inai, Akihiro Inoue, Atsushi Yamamoto, Shuji Sakai, Masahiro Jinzaki
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引用次数: 0

摘要

背景:修复性法洛四联症(rTOF)患者的肺反流分数(RF)是治疗干预的重要指标。然而,肺动脉几何形状和湍流对测量精度的影响尚不清楚。目的:评估4D血流mri衍生和2D相位对比(2D- pc) RF评估的可靠性,确定临床有用的测量位置,并研究导致变异性的因素。研究类型:回顾性。人群/受试者:34例rTOF患者(女性21例,年龄45.2±14.4岁)。场强/序列:3.0 T;平衡稳态自由进动(bSSFP)电影,时间分辨2D-PC分段梯度回波(2D-PC)和时间分辨速度敏化三维梯度回波与回波平面成像读出(4D流)序列。评估:经导管肺瓣膜置换术(TPVI)术前及术后3个月行MRI检查。通过bSSFP前后的影像数据评估右心室舒张末容积指数(RVEDVi),以评估右心室重构。采用2D-PC和4D流法测量MPA后向、前向流量(BFV、FFV)和RF。分析了从右心室流出道到远端MPA的六个等距4D流平面,其中一个平面与2D-PC位置相匹配。并对各4D流面进行了MPA和涡面积的评估。统计测试:Spearman’s rho评估了2D-PC和4D血流参数之间的相关性,接收器工作特征曲线下面积(AUC)评估了RF与TVPI前后RVEDVi百分比变化之间的关系。结果:匹配MPA平面的2D-PC和4D流量测量结果显著相关(RF: ρ = 0.65, FFV: ρ = 0.76, BFV: ρ = 0.87)。RF随平面变化,距瓣膜远端10mm平面与TPVI术后RVEDVi降低最相关(AUC = 0.84)。平面间FFV变化与扩张和狭窄显著相关(ρ = 0.432, -0.618),而BFV仅与扩张相关(ρ = 0.581);旋涡面积增大与流量变化无显著相关性。数据结论:2D-PC与4D流量测量具有较高的相关性,但4D流量精度取决于平面位置和几何形状。证据等级:3。技术功效:第二阶段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reliability of 4D Flow MRI-Derived Pulmonary Regurgitant Fraction in Repaired Tetralogy of Fallot: Impact of Measurement Location and Pulmonary Artery Geometry.

Background: Pulmonary regurgitant fraction (RF) in patients with repaired tetralogy of Fallot (rTOF) is an important indicator for therapeutic intervention. However, the impact of pulmonary artery geometry and turbulent flow on measurement accuracy is unclear.

Purpose: To evaluate the reliability of 4D flow MRI-derived and 2D phase contrast (2D-PC) RF assessments, identify clinically useful measurement locations, and investigate factors contributing to variability.

Study type: Retrospective.

Population/subjects: Thirty-four rTOF patients (21 female; age 45.2 ± 14.4 years).

Field strength/sequence: 3.0 T; balanced steady-state free precession (bSSFP) cine, time-resolved 2D-PC segmented gradient echo (2D-PC), and time-resolved velocity-sensitized 3D gradient echo with echo planar imaging readout (4D flow) sequences.

Assessment: MRI was performed before and 3 months after transcatheter pulmonary valve replacement (TPVI). Indexed right ventricular end-diastolic volume (RVEDVi) was assessed in pre/post bSSFP cine data to evaluate RV remodeling. MPA backward and forward flow volumes (BFV, FFV) and RF were measured using 2D-PC and 4D flow. Six equidistant 4D flow planes from the right ventricular outflow tract to the distal MPA were analyzed, with one additional plane matched to the 2D-PC location. MPA and vortex areas were also assessed for each 4D flow plane.

Statistical tests: Spearman's rho assessed correlations between 2D-PC and 4D flow parameters, and area under the receiver operating characteristic curve (AUC) assessed the association between RF and the pre/post TVPI percentage change in RVEDVi.

Significance: p < 0.05.

Results: 2D-PC and 4D flow measurements at the matched MPA plane correlated significantly (RF: ρ = 0.65, FFV: ρ = 0.76, BFV: ρ = 0.87). RF varied by plane, and the plane 10 mm distal to the valve best associated with RVEDVi reduction after TPVI (AUC = 0.84). Changes in FFV between planes significantly correlated with dilatation and stenosis (ρ = 0.432, -0.618), whereas BFV correlated with dilatation alone (ρ = 0.581); however, vortex area enlargement showed no significant association with flow volume changes.

Data conclusion: 2D-PC and 4D flow measurements show high correlations, but 4D flow accuracy depends on plane location and geometry.

Evidence level: 3.

Technical efficacy: Stage 2.

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来源期刊
CiteScore
9.70
自引率
6.80%
发文量
494
审稿时长
2 months
期刊介绍: The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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