血清基质金属蛋白酶及其抑制剂水平在腹股沟疝病因中的作用。

IF 2.4 2区医学 Q1 SURGERY

Hernia Pub Date : 2025-09-23 DOI:10.1007/s10029-025-03477-7

Hasan Basoglu, Fatih Yanar, Berke Sengun, Ibrahim Fethi Azamat, Hakan Yanar, Elif Ozkok

{"title":"血清基质金属蛋白酶及其抑制剂水平在腹股沟疝病因中的作用。","authors":"Hasan Basoglu, Fatih Yanar, Berke Sengun, Ibrahim Fethi Azamat, Hakan Yanar, Elif Ozkok","doi":"10.1007/s10029-025-03477-7","DOIUrl":null,"url":null,"abstract":"Aim: Inguinal hernias are one of the most common operations performed worldwide, but etiopathogenesis remains important in current practice. Recent studies have frequently examined factors affecting the extracellular matrix and collagens and their association with hernias. This study aimed to investigate the role of matrix metalloproteinases (MMPs) and their inhibitors in the etiopathogenesis of inguinal hernia.Methods: Serum samples obtained from 90 male inguinal hernia patients and 70 male control patients who presented to our clinic between March 15, 2024, and September 30, 2024, were analyzed using the ELISA method. Serum levels of matrix metalloproteinases (MMP-1, MMP-8, MMP-13) and tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2) were measured. The serum level results were compared in terms of net MMP activity, which was determined by calculating the MMP/TIMP ratios.Results: The serum level of MMP-1 was found to be significantly higher in the hernia group (9.1 vs. 7.5; p < 0.001). No significant differences were observed in the levels of other enzymes. In terms of net MMP activity, the ratios of MMP-1/TIMP-1 (hernia: 1.1 vs. control: 0.8, p = 0.01), MMP-1/TIMP-2 (hernia: 0.3 vs. control: 0.2, p < 0.001), and MMP-13/TIMP-2 (hernia: 0.14 vs. control: 0.11, p = 0.046) were higher in the hernia group, whereas the MMP-8/TIMP-1 ratio (hernia: 4.5 vs. control: 7.0, p = 0.017) was lower.Conclusion: In the inguinal hernia group, the serum level of MMP-1 and net MMP activity were increased, while the MMP-8/TIMP-1 ratio was decreased compared to the control group. These findings suggest that these markers may play a role in the etiopathogenesis of hernia.","PeriodicalId":13168,"journal":{"name":"Hernia","volume":"29 1","pages":"280"},"PeriodicalIF":2.4000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of serum levels of matrix metalloproteinases and their inhibitors in the etiology of inguinal hernia.\",\"authors\":\"Hasan Basoglu, Fatih Yanar, Berke Sengun, Ibrahim Fethi Azamat, Hakan Yanar, Elif Ozkok\",\"doi\":\"10.1007/s10029-025-03477-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aim: Inguinal hernias are one of the most common operations performed worldwide, but etiopathogenesis remains important in current practice. Recent studies have frequently examined factors affecting the extracellular matrix and collagens and their association with hernias. This study aimed to investigate the role of matrix metalloproteinases (MMPs) and their inhibitors in the etiopathogenesis of inguinal hernia.Methods: Serum samples obtained from 90 male inguinal hernia patients and 70 male control patients who presented to our clinic between March 15, 2024, and September 30, 2024, were analyzed using the ELISA method. Serum levels of matrix metalloproteinases (MMP-1, MMP-8, MMP-13) and tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2) were measured. The serum level results were compared in terms of net MMP activity, which was determined by calculating the MMP/TIMP ratios.Results: The serum level of MMP-1 was found to be significantly higher in the hernia group (9.1 vs. 7.5; p < 0.001). No significant differences were observed in the levels of other enzymes. In terms of net MMP activity, the ratios of MMP-1/TIMP-1 (hernia: 1.1 vs. control: 0.8, p = 0.01), MMP-1/TIMP-2 (hernia: 0.3 vs. control: 0.2, p < 0.001), and MMP-13/TIMP-2 (hernia: 0.14 vs. control: 0.11, p = 0.046) were higher in the hernia group, whereas the MMP-8/TIMP-1 ratio (hernia: 4.5 vs. control: 7.0, p = 0.017) was lower.Conclusion: In the inguinal hernia group, the serum level of MMP-1 and net MMP activity were increased, while the MMP-8/TIMP-1 ratio was decreased compared to the control group. These findings suggest that these markers may play a role in the etiopathogenesis of hernia.\",\"PeriodicalId\":13168,\"journal\":{\"name\":\"Hernia\",\"volume\":\"29 1\",\"pages\":\"280\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Hernia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10029-025-03477-7\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hernia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10029-025-03477-7","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

摘要

目的：腹股沟疝是世界范围内最常见的手术之一，但发病机制在目前的实践中仍然很重要。最近的研究经常检查影响细胞外基质和胶原的因素及其与疝气的关系。本研究旨在探讨基质金属蛋白酶（MMPs）及其抑制剂在腹股沟疝发病中的作用。方法：对2024年3月15日至2024年9月30日在我院就诊的90例男性腹股沟疝患者和70例男性对照患者的血清样本进行ELISA分析。测定血清基质金属蛋白酶（MMP-1、MMP-8、MMP-13）和组织金属蛋白酶抑制剂（TIMP-1、TIMP-2）水平。根据净MMP活性对血清水平结果进行比较，净MMP活性通过计算MMP/TIMP比值确定。结果：腹股沟疝组血清MMP-1水平明显升高（9.1 vs. 7.5）； p结论：腹股沟疝组血清MMP-1水平和净MMP活性均升高，而MMP-8/TIMP-1比值较对照组降低。这些发现提示这些标志物可能在疝的发病机制中起作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The role of serum levels of matrix metalloproteinases and their inhibitors in the etiology of inguinal hernia.

Aim: Inguinal hernias are one of the most common operations performed worldwide, but etiopathogenesis remains important in current practice. Recent studies have frequently examined factors affecting the extracellular matrix and collagens and their association with hernias. This study aimed to investigate the role of matrix metalloproteinases (MMPs) and their inhibitors in the etiopathogenesis of inguinal hernia.

Methods: Serum samples obtained from 90 male inguinal hernia patients and 70 male control patients who presented to our clinic between March 15, 2024, and September 30, 2024, were analyzed using the ELISA method. Serum levels of matrix metalloproteinases (MMP-1, MMP-8, MMP-13) and tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2) were measured. The serum level results were compared in terms of net MMP activity, which was determined by calculating the MMP/TIMP ratios.

Results: The serum level of MMP-1 was found to be significantly higher in the hernia group (9.1 vs. 7.5; p < 0.001). No significant differences were observed in the levels of other enzymes. In terms of net MMP activity, the ratios of MMP-1/TIMP-1 (hernia: 1.1 vs. control: 0.8, p = 0.01), MMP-1/TIMP-2 (hernia: 0.3 vs. control: 0.2, p < 0.001), and MMP-13/TIMP-2 (hernia: 0.14 vs. control: 0.11, p = 0.046) were higher in the hernia group, whereas the MMP-8/TIMP-1 ratio (hernia: 4.5 vs. control: 7.0, p = 0.017) was lower.

Conclusion: In the inguinal hernia group, the serum level of MMP-1 and net MMP activity were increased, while the MMP-8/TIMP-1 ratio was decreased compared to the control group. These findings suggest that these markers may play a role in the etiopathogenesis of hernia.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Hernia SURGERY-

CiteScore

4.90

自引率

26.10%

发文量

171

审稿时长

4-8 weeks

期刊介绍： Hernia was founded in 1997 by Jean P. Chevrel with the purpose of promoting clinical studies and basic research as they apply to groin hernias and the abdominal wall . Since that time, a true revolution in the field of hernia studies has transformed the field from a ”simple” disease to one that is very specialized. While the majority of surgeries for primary inguinal and abdominal wall hernia are performed in hospitals worldwide, complex situations such as multi recurrences, complications, abdominal wall reconstructions and others are being studied and treated in specialist centers. As a result, major institutions and societies are creating specific parameters and criteria to better address the complexities of hernia surgery. Hernia is a journal written by surgeons who have made abdominal wall surgery their specific field of interest, but we will consider publishing content from any surgeon who wishes to improve the science of this field. The Journal aims to ensure that hernia surgery is safer and easier for surgeons as well as patients, and provides a forum to all surgeons in the exchange of new ideas, results, and important research that is the basis of professional activity.