{"title":"Edward F. Adolph杰出讲座:蛋白质和能量代谢-一种不断变化的状态。","authors":"Benjamin F Miller","doi":"10.1152/japplphysiol.00762.2025","DOIUrl":null,"url":null,"abstract":"<p><p>Physiology processes are integrated, dynamic, and periodic, and thus benefit from methods that capture their dynamic nature. Since we are often limited to discrete sampling points in physiological studies, many methods provide snapshots of a system. However, these snapshots can at times be limited in their ability to understand the underlying events. This article is a summary of my 2025 Adolph Lecture and discusses how tracers (particularly, stable isotopes) go beyond mere snapshots to provide important insight into dynamic events. The article is part review and part narrative that provides insight into my scientific journey and the thought process that went into the design of the highlighted studies. I primarily feature articles published in APS journals and note what insight the tracer-based measurements provide. I hope that the reader comes away with an appreciation of the complexity of physiological studies and why tracer-based studies are in fact mechanistic.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Edward F. Adolph Distinguished Lecture: Protein & Energy Metabolism - A State of Flux.\",\"authors\":\"Benjamin F Miller\",\"doi\":\"10.1152/japplphysiol.00762.2025\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Physiology processes are integrated, dynamic, and periodic, and thus benefit from methods that capture their dynamic nature. Since we are often limited to discrete sampling points in physiological studies, many methods provide snapshots of a system. However, these snapshots can at times be limited in their ability to understand the underlying events. This article is a summary of my 2025 Adolph Lecture and discusses how tracers (particularly, stable isotopes) go beyond mere snapshots to provide important insight into dynamic events. The article is part review and part narrative that provides insight into my scientific journey and the thought process that went into the design of the highlighted studies. I primarily feature articles published in APS journals and note what insight the tracer-based measurements provide. I hope that the reader comes away with an appreciation of the complexity of physiological studies and why tracer-based studies are in fact mechanistic.</p>\",\"PeriodicalId\":15160,\"journal\":{\"name\":\"Journal of applied physiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-09-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of applied physiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1152/japplphysiol.00762.2025\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of applied physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1152/japplphysiol.00762.2025","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
Edward F. Adolph Distinguished Lecture: Protein & Energy Metabolism - A State of Flux.
Physiology processes are integrated, dynamic, and periodic, and thus benefit from methods that capture their dynamic nature. Since we are often limited to discrete sampling points in physiological studies, many methods provide snapshots of a system. However, these snapshots can at times be limited in their ability to understand the underlying events. This article is a summary of my 2025 Adolph Lecture and discusses how tracers (particularly, stable isotopes) go beyond mere snapshots to provide important insight into dynamic events. The article is part review and part narrative that provides insight into my scientific journey and the thought process that went into the design of the highlighted studies. I primarily feature articles published in APS journals and note what insight the tracer-based measurements provide. I hope that the reader comes away with an appreciation of the complexity of physiological studies and why tracer-based studies are in fact mechanistic.
期刊介绍:
The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.