Edward F. Adolph杰出讲座:蛋白质和能量代谢-一种不断变化的状态。

IF 3.3 3区 医学 Q1 PHYSIOLOGY
Benjamin F Miller
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引用次数: 0

摘要

生理过程是综合的、动态的和周期性的,因此从捕捉其动态本质的方法中受益。由于我们在生理研究中经常受到离散采样点的限制,许多方法提供了系统的快照。然而,这些快照在理解底层事件的能力上有时会受到限制。本文是我的2025 Adolph讲座的总结,并讨论了示踪剂(特别是稳定同位素)如何超越简单的快照,以提供对动态事件的重要见解。这篇文章部分是回顾,部分是叙述,它提供了我的科学旅程和思考过程的洞察力,进入了重点研究的设计。我主要介绍发表在APS期刊上的文章,并指出基于示踪剂的测量所提供的见解。我希望读者能够理解生理研究的复杂性,以及为什么基于示踪剂的研究实际上是机械的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Edward F. Adolph Distinguished Lecture: Protein & Energy Metabolism - A State of Flux.

Physiology processes are integrated, dynamic, and periodic, and thus benefit from methods that capture their dynamic nature. Since we are often limited to discrete sampling points in physiological studies, many methods provide snapshots of a system. However, these snapshots can at times be limited in their ability to understand the underlying events. This article is a summary of my 2025 Adolph Lecture and discusses how tracers (particularly, stable isotopes) go beyond mere snapshots to provide important insight into dynamic events. The article is part review and part narrative that provides insight into my scientific journey and the thought process that went into the design of the highlighted studies. I primarily feature articles published in APS journals and note what insight the tracer-based measurements provide. I hope that the reader comes away with an appreciation of the complexity of physiological studies and why tracer-based studies are in fact mechanistic.

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来源期刊
CiteScore
6.00
自引率
9.10%
发文量
296
审稿时长
2-4 weeks
期刊介绍: The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.
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