{"title":"阿尔茨海默氏症患者躁动的可改变因素探讨疾病：综合评估。","authors":"Xinyi Qian, Bo Hong, Yu Xu, Shifu Xiao, Xia Li, Ling Yue","doi":"10.1159/000548514","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to comprehensively assess the impact of caregiver, environmental, and individual factors on agitation symptoms in Alzheimer's disease (AD) patients, identifying key modifiable factors.</p><p><strong>Methods: </strong>From October 2022 to June 2023, 220 participants (110 AD patients and their caregivers) were recruited from Shanghai Mental Health Center. AD patients completed demographics, lifestyle, medical history surveys, and neuropsychological tests, e.g. MMSE, Geriatric Depression Scale (GDS). Caregivers completed the Neuropsychiatric Inventory, environmental factors questionnaire, and emotional state assessments (Hamilton Depression & Anxiety Scales). Agitation severity was assessed using the Cohen-Mansfield Agitation Inventory (CMAI). Group differences and relationships between potential factors and agitation were analyzed.</p><p><strong>Results: </strong>Among 110 AD patients, 56.36% exhibited agitation. The agitation group had more male patients (p=0.012) and female caregivers (p=0.003), lacked courtyard/garden views (p=0.007), had lower MMSE (p=0.005) and GDS scores (p=0.012). After adjusting variables, access to rooms with courtyard/garden views (OR=0.218, p=0.023), male caregivers (OR=0.235, p=0.004), and higher MMSE scores (OR=0.197, p=0.003) emerged as protective factors against agitation. Male caregiver presence was associated with lower agitation incidence.</p><p><strong>Conclusions: </strong>Improving living environments, promoting male caregivers, enhancing caregiver support, and early cognitive intervention may reduce agitation in AD patients.</p>","PeriodicalId":11126,"journal":{"name":"Dementia and Geriatric Cognitive Disorders","volume":" ","pages":"1-22"},"PeriodicalIF":1.9000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring Modifiable Factors Influencing Agitation in Alzheimer's Disease: A Comprehensive Assessment.\",\"authors\":\"Xinyi Qian, Bo Hong, Yu Xu, Shifu Xiao, Xia Li, Ling Yue\",\"doi\":\"10.1159/000548514\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>This study aimed to comprehensively assess the impact of caregiver, environmental, and individual factors on agitation symptoms in Alzheimer's disease (AD) patients, identifying key modifiable factors.</p><p><strong>Methods: </strong>From October 2022 to June 2023, 220 participants (110 AD patients and their caregivers) were recruited from Shanghai Mental Health Center. AD patients completed demographics, lifestyle, medical history surveys, and neuropsychological tests, e.g. MMSE, Geriatric Depression Scale (GDS). Caregivers completed the Neuropsychiatric Inventory, environmental factors questionnaire, and emotional state assessments (Hamilton Depression & Anxiety Scales). Agitation severity was assessed using the Cohen-Mansfield Agitation Inventory (CMAI). Group differences and relationships between potential factors and agitation were analyzed.</p><p><strong>Results: </strong>Among 110 AD patients, 56.36% exhibited agitation. The agitation group had more male patients (p=0.012) and female caregivers (p=0.003), lacked courtyard/garden views (p=0.007), had lower MMSE (p=0.005) and GDS scores (p=0.012). After adjusting variables, access to rooms with courtyard/garden views (OR=0.218, p=0.023), male caregivers (OR=0.235, p=0.004), and higher MMSE scores (OR=0.197, p=0.003) emerged as protective factors against agitation. Male caregiver presence was associated with lower agitation incidence.</p><p><strong>Conclusions: </strong>Improving living environments, promoting male caregivers, enhancing caregiver support, and early cognitive intervention may reduce agitation in AD patients.</p>\",\"PeriodicalId\":11126,\"journal\":{\"name\":\"Dementia and Geriatric Cognitive Disorders\",\"volume\":\" \",\"pages\":\"1-22\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-09-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dementia and Geriatric Cognitive Disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000548514\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dementia and Geriatric Cognitive Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000548514","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Exploring Modifiable Factors Influencing Agitation in Alzheimer's Disease: A Comprehensive Assessment.
Introduction: This study aimed to comprehensively assess the impact of caregiver, environmental, and individual factors on agitation symptoms in Alzheimer's disease (AD) patients, identifying key modifiable factors.
Methods: From October 2022 to June 2023, 220 participants (110 AD patients and their caregivers) were recruited from Shanghai Mental Health Center. AD patients completed demographics, lifestyle, medical history surveys, and neuropsychological tests, e.g. MMSE, Geriatric Depression Scale (GDS). Caregivers completed the Neuropsychiatric Inventory, environmental factors questionnaire, and emotional state assessments (Hamilton Depression & Anxiety Scales). Agitation severity was assessed using the Cohen-Mansfield Agitation Inventory (CMAI). Group differences and relationships between potential factors and agitation were analyzed.
Results: Among 110 AD patients, 56.36% exhibited agitation. The agitation group had more male patients (p=0.012) and female caregivers (p=0.003), lacked courtyard/garden views (p=0.007), had lower MMSE (p=0.005) and GDS scores (p=0.012). After adjusting variables, access to rooms with courtyard/garden views (OR=0.218, p=0.023), male caregivers (OR=0.235, p=0.004), and higher MMSE scores (OR=0.197, p=0.003) emerged as protective factors against agitation. Male caregiver presence was associated with lower agitation incidence.
Conclusions: Improving living environments, promoting male caregivers, enhancing caregiver support, and early cognitive intervention may reduce agitation in AD patients.
期刊介绍：
As a unique forum devoted exclusively to the study of cognitive dysfunction, ''Dementia and Geriatric Cognitive Disorders'' concentrates on Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field.
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