Giovanni Aprile, Cedric Devos, Thomas Vetter, Gerard Capellades, Kevin P. Girard, Christopher L. Burcham, Venkateswarlu Bhamidi, Daniel Green, Torsten Stelzer, Richard D. Braatz, Allan S. Myerson
{"title":"反思药物连续结晶的障碍","authors":"Giovanni Aprile, Cedric Devos, Thomas Vetter, Gerard Capellades, Kevin P. Girard, Christopher L. Burcham, Venkateswarlu Bhamidi, Daniel Green, Torsten Stelzer, Richard D. Braatz, Allan S. Myerson","doi":"10.1038/s44286-025-00268-w","DOIUrl":null,"url":null,"abstract":"This Comment explores why continuous crystallization, despite its success in other industries, remains underutilized in pharmaceutical manufacturing. Among other challenges, we highlight two core issues: the lack of off-the-shelf small-scale equipment with integrated monitoring tools, and the absence of compatible continuous downstream units for filtration and drying, both of which limit practical implementation.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 9","pages":"520-523"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reflecting on barriers to continuous pharmaceutical crystallization\",\"authors\":\"Giovanni Aprile, Cedric Devos, Thomas Vetter, Gerard Capellades, Kevin P. Girard, Christopher L. Burcham, Venkateswarlu Bhamidi, Daniel Green, Torsten Stelzer, Richard D. Braatz, Allan S. Myerson\",\"doi\":\"10.1038/s44286-025-00268-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This Comment explores why continuous crystallization, despite its success in other industries, remains underutilized in pharmaceutical manufacturing. Among other challenges, we highlight two core issues: the lack of off-the-shelf small-scale equipment with integrated monitoring tools, and the absence of compatible continuous downstream units for filtration and drying, both of which limit practical implementation.\",\"PeriodicalId\":501699,\"journal\":{\"name\":\"Nature Chemical Engineering\",\"volume\":\"2 9\",\"pages\":\"520-523\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Chemical Engineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44286-025-00268-w\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Chemical Engineering","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44286-025-00268-w","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Reflecting on barriers to continuous pharmaceutical crystallization
This Comment explores why continuous crystallization, despite its success in other industries, remains underutilized in pharmaceutical manufacturing. Among other challenges, we highlight two core issues: the lack of off-the-shelf small-scale equipment with integrated monitoring tools, and the absence of compatible continuous downstream units for filtration and drying, both of which limit practical implementation.