Marcell Papp, Florence Stoffel, Marcos Gil-Garcia, Lenka Faltova, Paolo Arosio
{"title":"生物分子凝聚物作为酶促反应的调节剂","authors":"Marcell Papp, Florence Stoffel, Marcos Gil-Garcia, Lenka Faltova, Paolo Arosio","doi":"10.1038/s44286-025-00242-6","DOIUrl":null,"url":null,"abstract":"Open compartments, termed biomolecular condensates, are involved in cellular reactions. This Comment highlights their ability to enhance robustness and control of reactions in space and time, going beyond mere acceleration or inhibition. They enable reaction engineering at the mesoscale, not just by altering concentrations but also by modifying the local environment.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":"2 7","pages":"394-397"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Biomolecular condensates as regulators of enzymatic reactions\",\"authors\":\"Marcell Papp, Florence Stoffel, Marcos Gil-Garcia, Lenka Faltova, Paolo Arosio\",\"doi\":\"10.1038/s44286-025-00242-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Open compartments, termed biomolecular condensates, are involved in cellular reactions. This Comment highlights their ability to enhance robustness and control of reactions in space and time, going beyond mere acceleration or inhibition. They enable reaction engineering at the mesoscale, not just by altering concentrations but also by modifying the local environment.\",\"PeriodicalId\":501699,\"journal\":{\"name\":\"Nature Chemical Engineering\",\"volume\":\"2 7\",\"pages\":\"394-397\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Chemical Engineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44286-025-00242-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Chemical Engineering","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44286-025-00242-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Biomolecular condensates as regulators of enzymatic reactions
Open compartments, termed biomolecular condensates, are involved in cellular reactions. This Comment highlights their ability to enhance robustness and control of reactions in space and time, going beyond mere acceleration or inhibition. They enable reaction engineering at the mesoscale, not just by altering concentrations but also by modifying the local environment.