孕妇血清钴浓度与甲状腺功能的关系：一项横断面研究

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2025-09-20 DOI:10.1016/j.jtemb.2025.127762

Xia Chai , Zhen Wang , Yujie Li , Jinlin Lei , Chong Guo , Weiwei Gu , Biyun Zhang , Huailan Guo

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引用次数: 0

摘要

在怀孕期间维持正常的甲状腺功能对孕产妇健康和胎儿生长发育至关重要。暴露于环境中的微量元素可能会影响孕妇的甲状腺功能，但钴的具体作用尚不清楚。本研究旨在系统评估孕妇血清钴浓度与甲状腺功能的关系。探索钴在微量元素混合物中的作用，进一步阐明其对甲状腺功能的潜在影响，为今后的研究提供理论和实验基础。方法对293名孕妇进行横断面研究，这些孕妇的微量元素和甲状腺功能数据均有效。测量包括血清钴、其他微量元素（铬、锰、铝、钒、镍）和甲状腺指标（Tg、TSH、FT3、FT4、TPOAb、TgAb）。采用多元线性回归、贝叶斯核机回归（BKMR）和限制三次样条（RCS）模型分析血清钴与甲状腺功能之间的关系，包括潜在的非线性效应。此外，研究了钴和其他微量元素之间的相互作用。结果高钴暴露与FT3、FT4水平呈显著负相关。线性趋势检验（P为趋势<； 0.001）进一步支持这种暴露-反应关系。BKMR分析表明，在所研究的所有微量金属中，钴对甲状腺功能的影响最为显著，微量元素之间没有观察到显著的相互作用。RCS分析进一步揭示钴与FT4呈非线性相关，与FT3呈线性负相关。Spearman相关分析显示钴与铬、锰、铝和钒呈正相关。结论孕妇血清钴浓度升高与FT3、FT4水平降低有显著相关性。研究结果表明，钴可能通过不同的机制影响FT3和FT4， FT4表现出非线性响应，而FT3则以稳定的线性方式下降。钴与几种微量元素呈正相关；然而，它们之间没有观察到显著的相互作用。这表明钴对孕妇甲状腺功能的影响可能是独立的。

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Association between serum cobalt concentration and thyroid function in pregnant women: A cross-sectional study

Background

Maintaining normal thyroid function during pregnancy is crucial for maternal health as well as fetal growth and development. Exposure to environmental trace elements may influence thyroid function in pregnant women, but the specific role of cobalt remains unclear. This study aimed to systematically assess the relationship between serum cobalt concentration and thyroid function in pregnant women. Additionally, it explored cobalt’s role within trace element mixtures to further elucidate its potential effects on thyroid function and provide theoretical and experimental foundations for future research.

Methods

This cross-sectional study included 293 pregnant women with valid trace element and thyroid function data from an initial 303 recruits. Measurements included serum cobalt, other trace elements (chromium, manganese, aluminum, vanadium, nickel), and thyroid indicators (Tg, TSH, FT3, FT4, TPOAb, TgAb).The relationships between serum cobalt and thyroid function, including potential non-linear effects, were analyzed using multiple linear regression, Bayesian kernel machine regression (BKMR), and restricted cubic spline (RCS) models. Additionally, interactions between cobalt and other trace elements were examined.

Results

Higher cobalt exposure was significantly negatively correlated with FT3 and FT4 levels. The linear trend test (P for trend < 0.001) further supported this exposure-response relationship. BKMR analysis indicated that cobalt had the most significant effect on thyroid function among all the trace metals studied, with no significant interactions observed between trace elements. RCS analysis further revealed a non-linear correlation between cobalt and FT4, as well as a linear negative correlation with FT3. Spearman correlation analysis showed a positive correlation between cobalt and chromium, manganese, aluminum, and vanadium.

Conclusion

Elevated serum cobalt concentration was significantly associated with lower FT3 and FT4 levels in pregnant women. The findings suggest that cobalt may affect FT3 and FT4 through different mechanisms, with FT4 exhibiting a non-linear response, while FT3 declines in a stable linear manner. Cobalt was positively correlated with several trace elements; however, no significant interactions were observed among them. This suggests that cobalt’s effect on thyroid function in pregnant women may be independent.

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.