铜光氧化还原催化饱和杂环的选择性α─C─H功能化

IF 16.9 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2025-09-22 DOI:10.1002/anie.202508093

Yi Lu, Ya-Jing Chen, Xu-Bing Li, Xiaodong Yang, Li-Zhu Wu, Hongbin Zhang

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引用次数: 0

摘要

利用铜-光氧化还原催化首次实现了具有相似C─H键的饱和杂环的位点选择性Cα─H功能化。这种非定向策略利用了铜光催化剂介导底物激活和光诱导能量转移的能力，为之前的HAT事件提供了出色的位点选择性。这种通用的新方案利用空气作为HAT前体和氧化剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Site-Selective α─C─H Functionalization of Saturated Heterocycles via Copper-Photoredox Catalysis

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Site-Selective α─C─H Functionalization of Saturated Heterocycles via Copper-Photoredox Catalysis

Site-selective C_α─H functionalization of saturated heterocycles with chemically similar C─H bonds is realized for the first time by copper-photoredox catalysis. This undirected strategy exploits copper photocatalyst's ability to mediate both substrate activation and photoinduced energy transfer, offering excellent site-selectivity complementary to previous HAT events. Such a general and new protocol utilizes air as the HAT precursor and oxidant.

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.